Clinical Laboratory Analysis - 2021 - Ghazizadeh - Age%E2%80%90 and sex%E2%80%90specific reference intervals for superoxide dismutase.pdf (578.36 kB)
Age- and sex-specific reference intervals for superoxide dismutase enzyme and several minerals in a healthy adult cohort
journal contribution
posted on 2023-06-15, 20:36 authored by Hamideh Ghazizadeh, Mary Kathryn Bohn, Mahdiyeh Yaghooti-Khorasani, Atieh Kamel Khodabandeh, Reza Zare-Feyzabadi, Ameneh Timar, Maryam Mohammadi-Bajgiran, Mohammad Reza Oladi, Mohadeseh Rohban, Habibollah Esmaily, Gordon FernsGordon Ferns, Khosrow Adeli, Majid Ghayour-MobarhanIntroduction The aim of this study was to establish RIs for clinically important markers including superoxide dismutase (SOD), serum copper, zinc, calcium, magnesium, and phosphate in a cohort of healthy Iranian adults. Materials A subsample from MASHAD cohort study was used to assess serum SOD, copper, zinc, calcium, magnesium and phosphate. Serum SOD was measured according to its inhibitory potential of pyrogallol oxidation. Micro- and macro-minerals were measured using flame atomic absorption spectrometry and a BT3000 autoanalyzer, respectively. Sex- and age-specific RIs were then calculated based on CLSI Ep28-A3 guidelines. Results Reference value distributions for studied parameters did not demonstrate any age-specific differences that were statistically significant. In addition, sex partitioning was not required for all parameters, apart from serum magnesium, which showed a wider range in females (0.81–1.26 mg/dl) compared with males (0.82–1.23 mg/dl). Conclusion The RIs established in this study can be expected to improve mineral assessment and clinical decision-making in the Iranian adult population.
History
Publication status
- Published
File Version
- Published version
Journal
Journal of Clinical Laboratory AnalysisISSN
0887-8013Publisher
WileyExternal DOI
Issue
9Volume
35Page range
1-8Article number
a23897Event location
United StatesDepartment affiliated with
- Division of Medical Education Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2022-01-14First Open Access (FOA) Date
2022-01-14First Compliant Deposit (FCD) Date
2022-01-14Usage metrics
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