Age- and sex-specific reference intervals for superoxide dismutase enzyme and several minerals in a healthy adult cohort

Ghazizadeh, Hamideh, Kathryn Bohn, Mary, Yaghooti-Khorasani, Mahdiyeh, Kamel Khodabandeh, Atieh, Zare-Feyzabadi, Reza, Timar, Ameneh, Mohammadi-Bajgiran, Maryam, Oladi, Mohammad Reza, Rohban, Mohadeseh, Esmaily, Habibollah, Ferns, Gordon A, Adeli, Khosrow and Ghayour-Mobarhan, Majid (2021) Age- and sex-specific reference intervals for superoxide dismutase enzyme and several minerals in a healthy adult cohort. Journal of Clinical Laboratory Analysis, 35 (9). a23897 1-8. ISSN 0887-8013

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Abstract

Introduction
The aim of this study was to establish RIs for clinically important markers including superoxide dismutase (SOD), serum copper, zinc, calcium, magnesium, and phosphate in a cohort of healthy Iranian adults.

Materials
A subsample from MASHAD cohort study was used to assess serum SOD, copper, zinc, calcium, magnesium and phosphate. Serum SOD was measured according to its inhibitory potential of pyrogallol oxidation. Micro- and macro-minerals were measured using flame atomic absorption spectrometry and a BT3000 autoanalyzer, respectively. Sex- and age-specific RIs were then calculated based on CLSI Ep28-A3 guidelines.

Results
Reference value distributions for studied parameters did not demonstrate any age-specific differences that were statistically significant. In addition, sex partitioning was not required for all parameters, apart from serum magnesium, which showed a wider range in females (0.81–1.26 mg/dl) compared with males (0.82–1.23 mg/dl).

Conclusion
The RIs established in this study can be expected to improve mineral assessment and clinical decision-making in the Iranian adult population.

Item Type: Article
Keywords: macro-mineral, micro-mineral, reference interval, superoxide dismutase
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 14 Jan 2022 10:55
Last Modified: 14 Jan 2022 11:00
URI: http://sro.sussex.ac.uk/id/eprint/103820

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