IMPARTER, Phase 1 of an intervention to improve patients’ understanding of gene expression profiling tests in breast cancer

Fallowfield, L J, Farewell, D, Jones, H, May, S, Catt, S, Starkings, R and Jenkins, V (2022) IMPARTER, Phase 1 of an intervention to improve patients’ understanding of gene expression profiling tests in breast cancer. Breast Cancer Research and Treatment. ISSN 0167-6806

[img] PDF - Published Version
Available under License Creative Commons Attribution.

Download (642kB)
[img] PDF - Accepted Version
Download (228kB)
[img] PDF - Other
Restricted to SRO admin only

Download (337kB)

Abstract

Purpose
To compare participants’ knowledge about gene expression profiling (GEP) tests and recurrence risks after reading an information leaflet with that following viewing of an information film.

Methods
Using a randomised cross-over design, at time-point one (T1), women aged 45–75 years without breast cancer either read leaflets or watched information films about Oncotype DX or Prosigna tests. Participants answered nine questions assessing knowledge (maximum score 18). Next-day information in the opposite modality was provided and knowledge re-assessed. Additional questions probed which format was easiest to understand, participants’ preferences for film or leaflet and their reasons for these.

Results
120 women participated (60 received OncotypeDX films and leaflets; 60 received the Prosigna versions). T1 mean knowledge scores were higher following film viewing (13.37) compared with that after reading leaflets (9.25) (mean difference 4.1; p < 0.0001; 95% CI 3.2, 5.0). When participants read leaflets first and subsequently viewed films, all increased their scores (mean + 6.08, from T1 of 9.25, p < 0.0001; 95% CI 5.44, 6.72). When films were viewed first, followed by leaflets, (36/60, 60%), participants’ scores declined (mean-1.55 from T1 of 13.37, p < 0.001; 95% CI -2.32, -0.78). A majority of participants expressed preferences for the films (88/120, 73.3%) irrespective as to whether they described OncotypeDX or Prosigna. Reasons included the clarity, ease of understanding, visual material and reassuring voice-over.

Conclusion
Discussions between oncologists and patients about recurrence risk results can be challenging. Information leaflets may aid understanding but often employ complex language. Information films significantly improved knowledge and were preferred by participants.

Item Type: Article
Keywords: Patient information, gene expression profiling tests, early breast cancer
Schools and Departments: Brighton and Sussex Medical School > Sussex Health Outcomes Research & Education in Cancer (SHORE-C)
Research Centres and Groups: Sussex Health Outcomes Research and Education in Cancer
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 07 Dec 2021 09:19
Last Modified: 03 Mar 2022 12:35
URI: http://sro.sussex.ac.uk/id/eprint/103268

View download statistics for this item

📧 Request an update
Project NameSussex Project NumberFunderFunder Ref
IMproving PAtient undeRstanding of GEP TEst Results (IMPARTER): development and testing of a patient information filmG2493BREAST CANCER RESEARCH FOUNDATIONUnset