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HIV frailty Syst review_FINAL_DRAFT_TL_June2016.pdf (293.12 kB)

Systematic review of prevalence and predictors of frailty in individuals with human immunodeficiency virus

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posted on 2023-06-10, 01:42 authored by Thomas LevettThomas Levett, Fiona V Cresswell, Muzaffar A Malik, Martin Fisher, Juliet Wright
Objectives To describe the prevalence and predictors of frailty in individuals with the human immunodeficiency virus (HIV) using systematic review methodology. Design Review. Setting Community. Participants Older adults with HIV. Measurements Medline, CINAHL, EMBASE, PsychInfo, and PubMed were searched for original observational studies with populations including individuals with HIV in which frailty was assessed using the frailty phenotype or a variant thereof. Studies were examined for frailty prevalence and predictors of the syndrome in those with HIV. Results Thirteen of 322 citations were included for full review. All demonstrated the presence of frailty in individuals with HIV, with prevalence ranging from 5% to 28.6% depending on population studied. HIV was a risk factor for frailty. Predictors of frailty included older age, comorbidities, diagnosis of acquired immunodeficiency syndrome, and low current CD4+ cell count. Conclusion HIV appears to be an independent risk factor for frailty, with frailty occurring in individuals with HIV at rates comparable with older individuals without HIV. Heterogeneity in study populations and frailty assessment measures hamper accurate description of the problem. Future longitudinal work with standardized methodology is needed to describe prevalence accurately and confirm predictors.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Journal of the American Geriatrics Society

ISSN

0002-8614

Publisher

Wiley

Issue

5

Volume

64

Page range

1006-1014

Event location

United States

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2021-11-12

First Open Access (FOA) Date

2021-11-12

First Compliant Deposit (FCD) Date

2021-11-12

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