Potential Role of Diabetes Mellitus-Associated T Cell Senescence in Epithelial Ovarian Cancer Omental Metastasis.pdf (891.24 kB)
Potential role of diabetes mellitus-associated T cell senescence in epithelial ovarian cancer omental metastasis
journal contribution
posted on 2023-06-10, 01:22 authored by Rhianne BroadwayRhianne Broadway, Nikita M Patel, Lucy E Hillier, Amal El-briri, Yulia S Korneva, Dmitry A Zinovkin, Md Zahidul I PranjolEpithelial ovarian cancer (EOC) is one of the most common causes of cancer-related deaths among women and is associated with age and age-related diseases. With increasing evidence of risks associated with metabolic inflammatory conditions, such as obesity and type 2 diabetes mellitus (T2DM), it is important to understand the complex pathophysiological mechanisms underlying cancer progression and metastasis. Age-related conditions can lead to both genotypic and phenotypic immune function alterations, such as induction of senescence, which can contribute to disease progression. Immune senescence is a common phenomenon in the ageing population, which is now known to play a role in multiple diseases, often detrimentally. EOC progression and metastasis, with the highest rates in the 75–79 age group in women, have been shown to be influenced by immune cells within the “milky spots” or immune clusters of the omentum. As T2DM has been re-ported to cause T cell senescence in both prediabetic and diabetic patients, there is a possibility that poor prognosis in EOC patients with T2DM is partly due to the accumulation of senescent T cells in the omentum. In this review, we explore this hypothesis with recent findings, potential therapeutic approaches, and future directions.
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- Published
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- Published version
Journal
LifeISSN
2075-1729Publisher
MDPIExternal DOI
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8Volume
11Page range
1-13Article number
a788Event location
SwitzerlandDepartment affiliated with
- Biochemistry Publications
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- Yes
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- Yes
Legacy Posted Date
2021-10-11First Open Access (FOA) Date
2021-10-11First Compliant Deposit (FCD) Date
2021-10-09Usage metrics
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