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Unraveling the links underlying arterial stiffness, bone demineralization, and muscle loss
journal contribution
posted on 2023-06-10, 01:22 authored by Lisanne Tap, Frances A Kirkham, Francesco Mattace-Raso, Laure Joly, Chakravarthi RajkumarChakravarthi Rajkumar, Athanase BenetosThe effects of elevated arterial stiffness on cardiovascular outcomes are widely studied, whereas the relation to noncardiovascular outcomes relevant to older persons, such as the effect on bones and muscles, is less well established. Arterial stiffness, bone demineralization, and muscle loss are all age-related processes with common risk factors, however, whether these are just parallel age-related alterations or whether these processes share common pathways is not yet understood. In this review, we outline previous literature using different assessments of arterial stiffness in various populations across the world to produce a comprehensive overview. Although there are many studies showing an association between arterial stiffness and loss of bone and muscle, the majority are cross-sectional and there is limited longitudinal evidence to justify causal conclusions. We also give an in-depth review of hypotheses and possible mechanisms which may underlie these associations including hormone dysregulation, impaired glucose metabolism, and inflammation. This narrative review highlights the associations between vessels, bones, and muscles with aging, offering insights into possible shared pathways.
History
Publication status
- Published
File Version
- Accepted version
Journal
HypertensionISSN
0194-911XPublisher
Lippincott, Williams & WilkinsIssue
3Volume
76Page range
629-639Event location
United StatesDepartment affiliated with
- Clinical and Experimental Medicine Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2021-10-11First Open Access (FOA) Date
2021-12-13First Compliant Deposit (FCD) Date
2021-12-13Usage metrics
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