Meiosis and beyond - understanding the mechanistic and evolutionary processes shaping the germline genome.pdf (699.05 kB)
Meiosis and beyond – understanding the mechanistic and evolutionary processes shaping the germline genome
journal contribution
posted on 2023-06-10, 01:21 authored by Roberta Bergero, Peter Ellis, Wilfried Haerty, Lee Larcombe, Iain Macaulay, Tarang Mehta, Mette Mogensen, David Murray, Will Nash, Matt NealeMatt Neale, Rebecca O'Connor, Christian Ottolini, Ned Peel, Luke Ramsey, Ben Skinner, othersThe separation of germ cell populations from the soma is part of the evolutionary transition to multicellularity. Only genetic information present in the germ cells will be inherited by future generations, and any molecular processes affecting the germline genome are therefore likely to be passed on. Despite its prevalence across taxonomic kingdoms, we are only starting to understand details of the underlying micro-evolutionary processes occurring at the germline genome level. These include segregation, recombination, mutation and selection and can occur at any stage during germline differentiation and mitotic germline proliferation to meiosis and post-meiotic gamete maturation. Selection acting on germ cells at any stage from the diploid germ cell to the haploid gametes may cause significant deviations from Mendelian inheritance and may be more widespread than previously assumed. The mechanisms that affect and potentially alter the genomic sequence and allele frequencies in the germline are pivotal to our understanding of heritability. With the rise of new sequencing technologies, we are now able to address some of these unanswered questions. In this review, we comment on the most recent developments in this field and identify current gaps in our knowledge.
History
Publication status
- Published
File Version
- Published version
Journal
Biological ReviewsISSN
1464-7931Publisher
WileyExternal DOI
Issue
3Volume
96Page range
822-841Event location
EnglandDepartment affiliated with
- Sussex Centre for Genome Damage Stability Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2021-10-11First Open Access (FOA) Date
2021-10-11First Compliant Deposit (FCD) Date
2021-10-08Usage metrics
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