AJGP revised2 manuscript EdK Dec2017290118.pdf (394.06 kB)
Vitamin D status and depressive symptoms in older adults: a role for physical functioning?
journal contribution
posted on 2023-06-10, 01:13 authored by Elisa J de Koning, Liset E M Elstgeest, Hannie C Comijs, Paul Lips, Judith J M Rijnhart, Harm van MarwijkHarm van Marwijk, Aartjan T F Beekman, Marjolein Visser, Brenda W J H Penninx, Natashja M van SchoorObjectives: Depressive symptoms and low vitamin D status are common in older persons and may be associated, but findings are inconsistent. This study investigated whether 25-hydroxyvitamin D (25(OH)D) concentrations are associated with depressive symptoms in older adults, both cross-sectionally and longitudinally. We also examined whether physical functioning could explain this relationship, to gain a better understanding of the underlying mechanisms. Methods: Data from two independent prospective cohorts of the Longitudinal Aging Study Amsterdam were used: an older cohort (=65 years, n = 1282, assessed from 1995–2002) and a younger-old cohort (55–65 years, n = 737, assessed from 2002–2009). Measurements: Depressive symptoms were measured at baseline and after 3 and 6 years with the Center of Epidemiological Studies Depression Scale. Cross-sectional and longitudinal linear regression techniques were used to examine the relationship between 25(OH)D and depressive symptoms. The mediating role of physical functioning was examined in the longitudinal models. Results: Cross-sectionally, associations were not significant after adjustment for confounders. Longitudinally, women in the older cohort with baseline 25(OH)D concentrations up to 75 nmol/L experienced 175 to 24% more depressive symptoms in the following 6 years, compared with women with 25(OH)D concentrations >75 nmol/L. Reduced physical performance partially mediated this relationship. In men and in the younger-old cohort, no significant associations were observed. Conclusions: Older women showed an inverse relationship between 25(OH)D and depressive symptoms over time, which may partially be explained by declining physical functioning. Replication of these findings by future studies is needed.
History
Publication status
- Published
File Version
- Accepted version
Journal
American Journal of Geriatric PsychiatryISSN
1064-7481Publisher
ElsevierExternal DOI
Issue
11Volume
26Page range
1131-1143Event location
EnglandDepartment affiliated with
- Primary Care and Public Health Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2021-10-01First Open Access (FOA) Date
2021-10-01First Compliant Deposit (FCD) Date
2021-10-01Usage metrics
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