Salpyran: a Cu(II) selective chelator with therapeutic potential

Devonport, Jack, Bodnár, Nikolett, McGown, Andrew, Maina, Mahmoud Bukar, Serpell, Louise C, Kállay, Csilla, Spencer, John and Kostakis, George E (2021) Salpyran: a Cu(II) selective chelator with therapeutic potential. Inorganic Chemistry, 60 (20). pp. 15310-15320. ISSN 0020-1669

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Abstract

We report the rational design of a tuneable Cu(II) chelating scaffold, 2-(((2-((pyridin-2-ylmethyl)amino)ethyl)amino)methyl)phenol, Salpyran. This tetradentate (3N,1O) ligand is predicated to have suitable permeation, has an extremely high affinity for Cu compared to clioquniol (pCu7.4 = 10.65 vs 5.91) and exhibits excellent selectivity for Cu(II) over Zn(II) in aqueous media. Solid and solution studies corroborate the formation of a stable [Cu(II)(3N,1O)]+ monocationic species at physiological pH values (7.4). Its action as an antioxidant was tested in ascorbate, tau and human prion protein assays which reveal that Salpyran prevents the formation of reactive oxygen species (ROS) from the binary Cu(II)/H2O2 system demonstrating its potential use as a therapeutic small molecule metal chelator (SMMC).

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 20 Sep 2021 07:09
Last Modified: 02 Mar 2022 12:30
URI: http://sro.sussex.ac.uk/id/eprint/101754

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The suprastructure-function relationship between amyloid assemblies and their toxic and infectious potentialsG2555BBSRC-BIOTECHNOLOGY & BIOLOGICAL SCIENCES RESEARCH COUNCILBBSRC Ref: BB/S003657/1