c9cs00199a.pdf (7.94 MB)
Half a century of amyloids: past, present and future
journal contribution
posted on 2023-06-10, 00:59 authored by Pu Chun Ke, Ruhong Zhou, Louise SerpellLouise Serpell, Roland Riek, Tuomas P J Knowles, Hilal A Lashuel, Ehud Gazit, Ian W Hamley, Thomas P Davis, Marcus Fändrich, Daniel Erik Otzen, Matthew R Chapman, Christopher M Dobson, David S Eisenberg, Raffaele MezzengaAmyloid diseases are global epidemics with profound health, social and economic implications and yet remain without a cure. This dire situation calls for research into the origin and pathological manifestations of amyloidosis to stimulate continued development of new therapeutics. In basic science and engineering, the cross-ß architecture has been a constant thread underlying the structural characteristics of pathological and functional amyloids, and realizing that amyloid structures can be both pathological and functional in nature has fuelled innovations in artificial amyloids, whose use today ranges from water purification to 3D printing. At the conclusion of a half century since Eanes and Glenner's seminal study of amyloids in humans, this review commemorates the occasion by documenting the major milestones in amyloid research to date, from the perspectives of structural biology, biophysics, medicine, microbiology, engineering and nanotechnology. We also discuss new challenges and opportunities to drive this interdisciplinary field moving forward. This journal is
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Publication status
- Published
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- Published version
Journal
Chemical Society ReviewsISSN
0306-0012Publisher
Royal Society of ChemistryExternal DOI
Issue
15Volume
49Page range
5473-5509Event location
EnglandDepartment affiliated with
- Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2021-09-17First Open Access (FOA) Date
2021-09-17First Compliant Deposit (FCD) Date
2021-09-15Usage metrics
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