Liqui-Tablet: the innovative oral dosage form using the newly developed Liqui-Mass technology

Lam, Matthew, Asare-Addo, Kofi and Nokhodchi, Ali (2021) Liqui-Tablet: the innovative oral dosage form using the newly developed Liqui-Mass technology. AAPS PharmSciTech, 22 (3). a85 1-11. ISSN 1530-9932

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Abstract

In this study, an attempt was made to produce Liqui-Tablets for the first time. This was carried out through the compaction of naproxen Liqui-Pellets. The incentive to convert the novel Liqui-Pellet into Liqui-Tablet was due to the array of inherent advantages of the popular and preferred tablet dosage form. The study showed that naproxen Liqui-Tablet could be successfully produced and the rapid drug release rate (100% drug release ~ 20 min) could be achieved under pH 1.2, where naproxen is insoluble. It was observed that the different pH of the dissolution medium affected the trend of drug release from formulations with varying amounts of liquid vehicle. The order of the fastest drug-releasing formulations was different depending on the pH used. The presence of Neusilin US2 showed considerable enhancement in the drug release rate as well as improving Liqui-Tablet robustness and hardness. Furthermore, images from X-ray micro-tomography displayed a uniform distribution of components in the Liqui-Tablet. The accelerated stability studies showed acceptable stability in terms of dissolution profile.

Item Type: Article
Keywords: Liqui-Pellet technology, Liqui-Tablet, dissolution enhancement, extrusion-spheronization, liquisolid technology, Administration, Oral, Anti-Inflammatory Agents, Non-Steroidal, Dosage Forms, Drug Compounding, Drug Liberation, Excipients, Naproxen, Tablets, Technology, Pharmaceutical
Schools and Departments: School of Life Sciences > Chemistry
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 10 Sep 2021 11:18
Last Modified: 10 Sep 2021 11:30
URI: http://sro.sussex.ac.uk/id/eprint/101625

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