Lam2021_Article_Liqui-TabletTheInnovativeOralD.pdf (2.03 MB)
Liqui-Tablet: the innovative oral dosage form using the newly developed Liqui-Mass technology
journal contribution
posted on 2023-06-10, 00:55 authored by Matthew Lam, Kofi Asare-Addo, Ali NokhodchiIn this study, an attempt was made to produce Liqui-Tablets for the first time. This was carried out through the compaction of naproxen Liqui-Pellets. The incentive to convert the novel Liqui-Pellet into Liqui-Tablet was due to the array of inherent advantages of the popular and preferred tablet dosage form. The study showed that naproxen Liqui-Tablet could be successfully produced and the rapid drug release rate (100% drug release ~ 20 min) could be achieved under pH 1.2, where naproxen is insoluble. It was observed that the different pH of the dissolution medium affected the trend of drug release from formulations with varying amounts of liquid vehicle. The order of the fastest drug-releasing formulations was different depending on the pH used. The presence of Neusilin US2 showed considerable enhancement in the drug release rate as well as improving Liqui-Tablet robustness and hardness. Furthermore, images from X-ray micro-tomography displayed a uniform distribution of components in the Liqui-Tablet. The accelerated stability studies showed acceptable stability in terms of dissolution profile.
History
Publication status
- Published
File Version
- Published version
Journal
AAPS PharmSciTechISSN
1530-9932Publisher
SpringerExternal DOI
Issue
3Volume
22Page range
1-11Article number
a85Event location
United StatesDepartment affiliated with
- Chemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2021-09-10First Open Access (FOA) Date
2021-09-10First Compliant Deposit (FCD) Date
2021-09-10Usage metrics
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