Sharma, Sunil V, Pubill-Ulldemolins, Cristina, Marelli, Enrico and Goss, Rebecca J M (2021) An expedient, mild and aqueous method for Suzuki–Miyaura diversification of (hetero)aryl halides or (poly)chlorinated pharmaceuticals. Organic Chemistry Frontiers. ISSN 2052-4129

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Abstract

The development of mild, aqueous conditions for the cross-coupling of highly functionalized (hetero)aryl chlorides or bromides is attractive, enabling their functionalization and diversification. Herein, we report a general method for Suzuki–Miyaura cross-coupling at 37 °C in aqueous media in the presence of air. We demonstrate application of this general methodology for derivatisation of (poly)chlorinated, medicinally active compounds and halogenated amino acids. The approach holds the potential to be a useful tool for late-stage functionalization or analogue generation.

Item Type:	Article
Schools and Departments:	School of Life Sciences > Chemistry
SWORD Depositor:	Mx Elements Account
Depositing User:	Mx Elements Account
Date Deposited:	09 Sep 2021 07:13
Last Modified:	09 Sep 2021 07:15
URI:	http://sro.sussex.ac.uk/id/eprint/101582

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