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An expedient, mild and aqueous method for Suzuki–Miyaura diversification of (hetero)aryl halides or (poly)chlorinated pharmaceuticals

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posted on 2023-06-10, 00:53 authored by Sunil V Sharma, Cristina Pubill-Ulldemolins, Enrico Marelli, Cristina Pubill Ulldemolins
The development of mild, aqueous conditions for the cross-coupling of highly functionalized (hetero)aryl chlorides or bromides is attractive, enabling their functionalization and diversification. Herein, we report a general method for Suzuki–Miyaura cross-coupling at 37 °C in aqueous media in the presence of air. We demonstrate application of this general methodology for derivatisation of (poly)chlorinated, medicinally active compounds and halogenated amino acids. The approach holds the potential to be a useful tool for late-stage functionalization or analogue generation.

History

Publication status

  • Published

File Version

  • Published version

Journal

Organic Chemistry Frontiers

ISSN

2052-4129

Publisher

Royal Society of Chemistry

Department affiliated with

  • Chemistry Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2021-09-09

First Open Access (FOA) Date

2021-09-09

First Compliant Deposit (FCD) Date

2021-09-09

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