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Skeletally tunable seven-membered-ring fused pyrroles
journal contribution
posted on 2023-06-10, 00:42 authored by Dimitrios Andreou, Nsikak Essien, Cristina Pubill Ulldemolins, Michael A Terzidis, Athanasios N Papadopoulos, George KostakisGeorge Kostakis, Ioannis N LykakisWe describe a copper-mediated method that enables the synthesis of seven-membered-ring fused pyrroles (7-mrFPs). The protocol proceeds via an in situ spiro-intermediate ring expansion and tolerates a library of 7-mrFP derivatives with a broad range of functional groups in a simple step with tangible parameters and substrate adaptations. These rare 7-mrFPs are now accessible on a millimolar scale, and selected examples exhibit high antioxidant activity.
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Publication status
- Published
File Version
- Accepted version
Journal
Organic LettersISSN
1523-7052Publisher
American Chemical SocietyExternal DOI
Issue
17Volume
23Page range
6685-6690Department affiliated with
- Chemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2021-08-26First Open Access (FOA) Date
2022-08-24First Compliant Deposit (FCD) Date
2021-08-26Usage metrics
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