Skeletally tunable seven-membered-ring fused pyrroles

Andreou, Dimitrios, Essien, Nsikak B, Pubill-Ulldemolins, Cristina, Terzidis, Michael A, Papadopoulos, Athanasios N, Kostakis, George and Lykakis, Ioannis N (2021) Skeletally tunable seven-membered-ring fused pyrroles. Organic Letters, 23 (17). pp. 6685-6690. ISSN 1523-7052

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We describe a copper-mediated method that enables the synthesis of seven-membered-ring fused pyrroles (7-mrFPs). The protocol proceeds via an in situ spiro-intermediate ring expansion and tolerates a library of 7-mrFP derivatives with a broad range of functional groups in a simple step with tangible parameters and substrate adaptations. These rare 7-mrFPs are now accessible on a millimolar scale, and selected examples exhibit high antioxidant activity.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 26 Aug 2021 08:53
Last Modified: 24 Aug 2022 01:00

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