Andreou, Dimitrios, Essien, Nsikak B, Pubill-Ulldemolins, Cristina, Terzidis, Michael A, Papadopoulos, Athanasios N, Kostakis, George and Lykakis, Ioannis N (2021) Skeletally tunable seven-membered-ring fused pyrroles. Organic Letters, 23 (17). pp. 6685-6690. ISSN 1523-7052
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Abstract
We describe a copper-mediated method that enables the synthesis of seven-membered-ring fused pyrroles (7-mrFPs). The protocol proceeds via an in situ spiro-intermediate ring expansion and tolerates a library of 7-mrFP derivatives with a broad range of functional groups in a simple step with tangible parameters and substrate adaptations. These rare 7-mrFPs are now accessible on a millimolar scale, and selected examples exhibit high antioxidant activity.
Item Type: | Article |
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Schools and Departments: | School of Life Sciences > Chemistry |
SWORD Depositor: | Mx Elements Account |
Depositing User: | Mx Elements Account |
Date Deposited: | 26 Aug 2021 08:53 |
Last Modified: | 22 Mar 2022 08:00 |
URI: | http://sro.sussex.ac.uk/id/eprint/101312 |
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