Andreou, Dimitrios, Essien, Nsikak B, Pubill-Ulldemolins, Cristina, Terzidis, Michael A, Papadopoulos, Athanasios N, Kostakis, George and Lykakis, Ioannis N (2021) Skeletally tunable seven-membered-ring fused pyrroles. Organic Letters, 23 (17). pp. 6685-6690. ISSN 1523-7052

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Abstract

We describe a copper-mediated method that enables the synthesis of seven-membered-ring fused pyrroles (7-mrFPs). The protocol proceeds via an in situ spiro-intermediate ring expansion and tolerates a library of 7-mrFP derivatives with a broad range of functional groups in a simple step with tangible parameters and substrate adaptations. These rare 7-mrFPs are now accessible on a millimolar scale, and selected examples exhibit high antioxidant activity.

Item Type:	Article
Schools and Departments:	School of Life Sciences > Chemistry
SWORD Depositor:	Mx Elements Account
Depositing User:	Mx Elements Account
Date Deposited:	26 Aug 2021 08:53
Last Modified:	22 Mar 2022 08:00
URI:	http://sro.sussex.ac.uk/id/eprint/101312

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