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RecQ helicases and topoisomerase III: genomic instability causing cancer and aging
journal contribution
posted on 2023-06-07, 13:54 authored by L. V. Laursen, L. Bjergbaek, Jo Murray, H. AndersenRecQ helicases have in recent years attracted increasing attention due to the important roles they play in maintaining genomic integrity, which is essential for the life of a cell and the survival of a species. Humans with mutations in RecQ homologues are cancer prone and suffer from premature aging. A great effort has therefore been made to understand the molecular mechanisms and the biological pathways, in which RecQ helicases are involved. It has become clear that these enzymes work in close concert with DNA topoisomerase III, and studies in both yeast and mammalian systems point to a role of the proteins in processes involving homologous recombination. In this review we discuss the genetic and biochemical evidence for possible functions of RecQ helicases and DNA topoisomerase III in multiple cellular processes such as DNA recombination, DNA replication, and cell cycle checkpoint control.
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- Published
Journal
BiogerontologyISSN
1573-6768External DOI
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5Volume
4Page range
275-87Full text available
- No
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- Yes
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2007-03-22Usage metrics
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