PrimPol_review_MCO.pdf (653.8 kB)
PrimPol—A new polymerase on the block
journal contribution
posted on 2023-06-10, 00:43 authored by Sean G Rudd, Julie Bianchi, Aidan DohertyAidan DohertyThe DNA-directed primase-polymerase PrimPol of the archaeo-eukaryotic primase superfamily represents an ancient solution to the many problems faced during genome duplication. This versatile enzyme is capable of initiating de novo DNA/RNA synthesis, DNA chain elongation, and has the capacity to bypass modifications that stall the replisome by trans-lesion synthesis or origin-independent re-priming, thus allowing discontinuous synthesis of the leading strand. Recent studies have shown that PrimPol is an important new player in replication fork progression in eukaryotic cells; this review summarizes our current understanding of PrimPol and highlights important questions that remain to be addressed.
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Publication status
- Published
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- Published version
Journal
Molecular and Cellular OncologyISSN
2372-3556Publisher
Taylor & FrancisExternal DOI
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2Volume
1Page range
1-10Article number
a960754Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2021-08-25First Open Access (FOA) Date
2021-08-25First Compliant Deposit (FCD) Date
2021-08-24Usage metrics
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