Rudd, Sean G, Bianchi, Julie and Doherty, Aidan J (2014) PrimPol—A new polymerase on the block. Molecular and Cellular Oncology, 1 (2). a960754 1-10. ISSN 2372-3556

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Abstract

The DNA-directed primase-polymerase PrimPol of the archaeo-eukaryotic primase superfamily represents an ancient solution to the many problems faced during genome duplication. This versatile enzyme is capable of initiating de novo DNA/RNA synthesis, DNA chain elongation, and has the capacity to bypass modifications that stall the replisome by trans-lesion synthesis or origin-independent re-priming, thus allowing discontinuous synthesis of the leading strand. Recent studies have shown that PrimPol is an important new player in replication fork progression in eukaryotic cells; this review summarizes our current understanding of PrimPol and highlights important questions that remain to be addressed.

Item Type:	Article
Schools and Departments:	School of Life Sciences > Sussex Centre for Genome Damage and Stability
SWORD Depositor:	Mx Elements Account
Depositing User:	Mx Elements Account
Date Deposited:	25 Aug 2021 08:49
Last Modified:	25 Aug 2021 08:49
URI:	http://sro.sussex.ac.uk/id/eprint/101290

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