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PrimPol—A new polymerase on the block

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journal contribution
posted on 2023-06-10, 00:43 authored by Sean G Rudd, Julie Bianchi, Aidan DohertyAidan Doherty
The DNA-directed primase-polymerase PrimPol of the archaeo-eukaryotic primase superfamily represents an ancient solution to the many problems faced during genome duplication. This versatile enzyme is capable of initiating de novo DNA/RNA synthesis, DNA chain elongation, and has the capacity to bypass modifications that stall the replisome by trans-lesion synthesis or origin-independent re-priming, thus allowing discontinuous synthesis of the leading strand. Recent studies have shown that PrimPol is an important new player in replication fork progression in eukaryotic cells; this review summarizes our current understanding of PrimPol and highlights important questions that remain to be addressed.

History

Publication status

  • Published

File Version

  • Published version

Journal

Molecular and Cellular Oncology

ISSN

2372-3556

Publisher

Taylor & Francis

Issue

2

Volume

1

Page range

1-10

Article number

a960754

Department affiliated with

  • Sussex Centre for Genome Damage Stability Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2021-08-25

First Open Access (FOA) Date

2021-08-25

First Compliant Deposit (FCD) Date

2021-08-24

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