Primpol—prime time to reprime

Guilliam, Thomas A and Doherty, Aidan J (2017) Primpol—prime time to reprime. Genes, 8 (1). a20 1-25. ISSN 2073-4425

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The complex molecular machines responsible for genome replication encounter many obstacles during their progression along DNA. Tolerance of these obstructions is critical for efficient and timely genome duplication. In recent years, primase-polymerase (PrimPol) has emerged as a new player involved in maintaining eukaryotic replication fork progression. This versatile replicative enzyme, a member of the archaeo-eukaryotic primase (AEP) superfamily, has the capacity to perform a range of template-dependent and independent synthesis activities. Here, we discuss the emerging roles of PrimPol as a leading strand repriming enzyme and describe the mechanisms responsible for recruiting and regulating the enzyme during this process. This review provides an overview and update of the current PrimPol literature, as well as highlighting unanswered questions and potential future avenues of investigation.

Item Type: Article
Keywords: AEP, DNA replication, PrimPol, damage tolerance, polymerase, primase, priming, translesion synthesis
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 25 Aug 2021 08:09
Last Modified: 25 Aug 2021 08:15

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