Alves, Mariana, Fernandes, Marília Andreia, Bahat, Gülistan, Benetos, Athanase, Clemente, Hugo, Grodzicki, Tomasz, Martínez-Sellés, Manuel, Mattace-Raso, Francesco, Rajkumar, Chakravarthi, Ungar, Andrea, Werner, Nikos, Strandberg, Timo E, EuGMS Special Interest Group inCardiovascular Medicine, and Unset (2021) Protecting older patients with cardiovascular diseases from COVID-19 complications using current medications. European Geriatric Medicine, 12 (4). pp. 725-739. ISSN 1878-7649

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Abstract

Purpose
In the pathogenesis of severe COVID-19 complications, derangements of renin–angiotensin–aldosterone system (RAAS), vascular endothelial dysfunction leading to inflammation and coagulopathy, and arrhythmias play an important role. Therefore, it is worth considering the use of currently available drugs to protect COVID-19 patients with cardiovascular diseases.

Methods
We review the current experience of conventional cardiovascular drugs [angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers, anticoagulants, acetosalicylic acid, antiarrhythmic drugs, statins] as well as some other drug classes (antidiabetic drugs, vitamin D and NSAIDs) frequently used by older patients with cardiovascular diseases. Data were sought from clinical databases for COVID-19 and appropriate key words. Conclusions and recommendations are based on a consensus among all authors.

Results
Several cardiovascular drugs have a potential to protect patients with COVID-19, although evidence is largely based on retrospective, observational studies. Despite propensity score adjustments used in many analyses observational studies are not equivalent to randomised controlled trials (RCTs). Ongoing RCTs include treatment with antithrombotics, pulmonary vasodilators, RAAS-related drugs, and colchicine. RCTs in the acute phase of COVID-19 may not, however, recognise the benefits of long term anti-atherogenic therapies, such as statins.

Conclusions
Most current cardiovascular drugs can be safely continued during COVID-19. Some drug classes may even be protective. Age-specific data are scarce, though, and conditions which are common in older patients (frailty, comorbidities, polypharmacy) must be individually considered for each drug group.

Item Type:	Article
Keywords:	Antiarrhytmic, Anticoaculant, Aspirin, COVID-19, Colchicine, Diabetes, NSAID, RAAS, Statin, Vitamin D
Schools and Departments:	Brighton and Sussex Medical School > Clinical and Experimental Medicine
SWORD Depositor:	Mx Elements Account
Depositing User:	Mx Elements Account
Date Deposited:	10 Aug 2021 08:18
Last Modified:	10 Aug 2021 08:18
URI:	http://sro.sussex.ac.uk/id/eprint/101036

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