Methods to disinfect and decontaminate SARS-CoV-2 a systematic review of iin vitroi studies.pdf (673.35 kB)
Methods to disinfect and decontaminate SARS-CoV-2: a systematic review of in vitro studies
journal contribution
posted on 2023-06-10, 00:34 authored by Chung Shing Kwok, Mustafa Dashti, Jacopo Tafuro, Mojtaba NasiriMojtaba Nasiri, Elena-Andra Muntean, Nicholas Wong, Timothy Kemp, George Hills, Christian D MallenBackground: Cleaning is a major control component for outbreaks of infection. However, for the SARS-CoV-2 pandemic, there is limited specific guidance regarding the proper disinfection methods that should be used. Methods: We conducted a systematic review of the literature on cleaning, disinfection or decontamination methods in the prevention of SARS-CoV-2. Results: A total of 27 studies were included, reporting a variety of methods with which the effectiveness of interventions were assessed. Virus was inoculated onto different types of material including masks, nasopharyngeal swabs, serum, laboratory plates and simulated saliva, tears or nasal fluid and then interventions were applied in an attempt to eliminate the virus including chemical, ultraviolet (UV) light irradiation, and heat and humidity. At body temperature (37°C) there is evidence that the virus will not be detectable after 2?days but this can be reduced to non-detection at 30?min at 56°C, 15?min at 65°C and 2?min at 98°C. Different experimental methods testing UV light have shown that it can inactivate the virus. Light of 254–365?nm has been used, including simulated sunlight. Many chemical agents including bleach, hand sanitiser, hand wash, soap, ethanol, isopropanol, guandinium thiocynate/t-octylphenoxypolyethoxyethanol, formaldehyde, povidone-iodine, 0.05% chlorhexidine, 0.1% benzalkonium chloride, acidic electrolysed water, Clyraguard copper iodine complex and hydrogen peroxide vapour have been shown to disinfect SARS-CoV-2. Conclusions: Heating, UV light irradiation and chemicals can be used to inactivate SARS-CoV-2 but there is insufficient evidence to support one measure over others in clinical practice.
History
Publication status
- Published
File Version
- Published version
Journal
Therapeutic Advances in Infectious DiseaseISSN
2049-9361Publisher
SAGE PublicationsExternal DOI
Volume
8Page range
1-12Event location
EnglandDepartment affiliated with
- Biochemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2021-08-09First Open Access (FOA) Date
2021-08-09First Compliant Deposit (FCD) Date
2021-08-06Usage metrics
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