Contribution of toll-like receptors and the NLRP3 inflammasome in rheumatoid arthritis pathophysiology

Unterberger, Sarah, Davies, Kevin A, Rambhatla, Srinivasa Bhargav and Sacre, Sandra (2021) Contribution of toll-like receptors and the NLRP3 inflammasome in rheumatoid arthritis pathophysiology. ImmunoTargets and Therapy, 10. pp. 285-298. ISSN 2253-1556

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Abstract

Rheumatoid arthritis (RA) is a progressive autoimmune disease that is characterized by inflammation of the synovial joints leading to cartilage and bone damage. The pathogenesis is sustained by the production of pro-inflammatory cytokines including tumor necrosis factor (TNF), interleukin (IL)-1 and IL-6, which can be targeted therapeutically to alleviate disease severity. Several innate immune receptors are suggested to contribute to the chronic inflammation in RA, through the production of pro-inflammatory factors in response to endogenous danger signals. Much research has focused on toll-like receptors and more recently the nucleotide-binding domain and leucine-rich repeat pyrin containing protein-3 (NLRP3) inflammasome, which is required for the processing and release of IL-1β. This review summarizes the current understanding of the potential involvement of these receptors in the initiation and maintenance of inflammation and tissue damage in RA and experimental arthritis models.

Item Type: Article
Keywords: rheumatoid arthritis, IL-1, IL-6, TNF, toll-like receptor, NLRP3 inflammasome
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 29 Jul 2021 09:22
Last Modified: 29 Jul 2021 09:30
URI: http://sro.sussex.ac.uk/id/eprint/100839

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