http://sro.sussex.ac.uk/ http://sro.sussex.ac.uk/images/sitelogo.png http://sro.sussex.ac.uk/ Tue, 21 Nov 2023 15:09:35 +0000 Tue, 21 Nov 2023 15:09:35 +0000 en Tue, 22 Mar 2022 09:55:02 +0000 http://sro.sussex.ac.uk/id/eprint/104973/ http://sro.sussex.ac.uk/id/eprint/104973/ O'Garro-Priddie, Edward (2022) The role of microRNAs in Drosophila larval locomotion. Doctoral thesis (PhD), University of Sussex. Fri, 17 Sep 2021 10:53:24 +0100 http://sro.sussex.ac.uk/id/eprint/101756/ http://sro.sussex.ac.uk/id/eprint/101756/ Teague, Rebecca Sarah (2021) Identification and characterisation of post-translational modifications that regulate human PrimPol. Doctoral thesis (PhD), University of Sussex. Wed, 30 Sep 2020 13:14:23 +0100 http://sro.sussex.ac.uk/id/eprint/93352/ http://sro.sussex.ac.uk/id/eprint/93352/ Overbury, Peter Charles (2020) Illuminating meaningful diversity in complex feature spaces through adaptive grid-based genetic algorithms. Doctoral thesis (PhD), University of Sussex. Wed, 06 May 2020 07:32:09 +0100 http://sro.sussex.ac.uk/id/eprint/91169/ http://sro.sussex.ac.uk/id/eprint/91169/ Patraquim, Pedro, Mumtaz, Muhammad Ali Shahzad, Pueyo, Jose Ignacio, Aspden, Julie Louise and Couso, Juan-Pablo (2020) Developmental regulation of canonical and small ORF translation from mRNAs. Genome Biology, 21. a128 1-26. ISSN 1474-760X Wed, 15 Apr 2020 07:27:40 +0100 http://sro.sussex.ac.uk/id/eprint/90742/ http://sro.sussex.ac.uk/id/eprint/90742/ Minchell, Nicola Elizabeth, Keszthelyi, Andrea and Baxter, Jonathan (2020) Cohesin causes replicative DNA damage by trapping DNA topological stress. Molecular cell, 78 (4). pp. 739-751. ISSN 1097-2765 Wed, 08 Jan 2020 10:54:15 +0000 http://sro.sussex.ac.uk/id/eprint/89224/ http://sro.sussex.ac.uk/id/eprint/89224/ Baeissa, Hanadi M and Pearl, Frances M G (2019) Identifying the impact of inframe insertions and deletions on protein function in cancer. Journal of Computational Biology. ISSN 1066-5277 Wed, 08 Jan 2020 08:35:41 +0000 http://sro.sussex.ac.uk/id/eprint/89223/ http://sro.sussex.ac.uk/id/eprint/89223/ Benstead-Hume, Graeme, Wooller, Sarah, Downs, Jessica and Pearl, Frances (2019) Defining signatures of arm-wise copy number change and their associated drivers in kidney cancers. International Journal of Molecular Sciences, 20 (22). a5762. ISSN 1661-6596 Tue, 07 Jan 2020 09:04:57 +0000 http://sro.sussex.ac.uk/id/eprint/88899/ http://sro.sussex.ac.uk/id/eprint/88899/ Gittens, William H, Johnson, Dominic J, Allison, Rachal M, Cooper, Tim J, Thomas, Holly and Neale, Matthew J (2019) A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genome. Nature Communications, 10. a4846. ISSN 2041-1723 Mon, 18 Nov 2019 07:33:54 +0000 http://sro.sussex.ac.uk/id/eprint/88135/ http://sro.sussex.ac.uk/id/eprint/88135/ Addis, Owen (2019) Polo-like kinase 1 (PLK1) promotes centromere protection against a PICH/BLM-mediated deformation pathway. Doctoral thesis (PhD), University of Sussex. Fri, 11 Oct 2019 11:39:04 +0100 http://sro.sussex.ac.uk/id/eprint/87050/ http://sro.sussex.ac.uk/id/eprint/87050/ Castellano, David, Eyre-Walker, Adam and Munch, Kasper (2019) Impact of mutation rate and selection at linked sites on DNA variation across the genomes of humans and other homininae. Genome Biology and Evolution. ISSN 1759-6653 Mon, 07 Oct 2019 17:39:18 +0100 http://sro.sussex.ac.uk/id/eprint/86816/ http://sro.sussex.ac.uk/id/eprint/86816/ Gibson, Beth and Eyre-Walker, Adam (2019) Investigating evolutionary rate variation in bacteria. Journal of Molecular Evolution. ISSN 0022-2844 Wed, 14 Aug 2019 10:00:19 +0100 http://sro.sussex.ac.uk/id/eprint/85002/ http://sro.sussex.ac.uk/id/eprint/85002/ Kozik, Zuzanna (2019) Investigation of DNA double-strand break-associated histone post-translational modifications using targeted mass spectrometry. Doctoral thesis (PhD), University of Sussex. Mon, 18 Mar 2019 13:19:37 +0000 http://sro.sussex.ac.uk/id/eprint/82573/ http://sro.sussex.ac.uk/id/eprint/82573/ Bergman, Juraj, Eyre-Walker, Adam and Unset (2019) Does adaptive protein evolution proceed by large or small steps at the amino acid level? Molecular Biology and Evolution, 36 (5). pp. 990-998. ISSN 0737-4038 Tue, 20 Nov 2018 12:40:23 +0000 http://sro.sussex.ac.uk/id/eprint/80315/ http://sro.sussex.ac.uk/id/eprint/80315/ Castellano, David, James, Jennifer and Eyre-Walker, Adam (2018) Nearly neutral evolution across the Drosophila melanogaster genome. Molecular Biology and Evolution, 35 (11). pp. 2685-2694. ISSN 0737-4038 Fri, 19 Oct 2018 13:30:27 +0100 http://sro.sussex.ac.uk/id/eprint/41738/ http://sro.sussex.ac.uk/id/eprint/41738/ Caser Tena, Teresa, Maerz, Lars, Szafranski, Karol, Groth, Marco, Blatte, Tamara, Donow, Cornelia, Matysik, Sabrina, Walther, Paul, Jeggo, Penelope A, Burkhalter, Martin and Philipp, Melanie (2019) Resting cells rely on the DNA helicase component MCM2 to build cilia. Nucleic Acids Research, 47 (1). pp. 134-151. ISSN 0305-1048 Wed, 17 Oct 2018 11:05:06 +0100 http://sro.sussex.ac.uk/id/eprint/79543/ http://sro.sussex.ac.uk/id/eprint/79543/ Kaschula, Richard, Pinho, Sofia and Alonso, Claudio R (2018) MicroRNA-dependent regulation of Hox gene expression sculpts fine-grain morphological patterns in a Drosophila appendage. Development, 145 (20). dev161133. ISSN 0950-1991 Fri, 20 Jul 2018 09:47:48 +0100 http://sro.sussex.ac.uk/id/eprint/77271/ http://sro.sussex.ac.uk/id/eprint/77271/ Towler, Benjamin P and Newbury, Sarah F (2018) Regulation of cytoplasmic RNA stability: lessons from drosophila. Wiley Interdisciplinary Reviews: RNA, 9 (6). pp. 1-20. ISSN 1757-7004 Wed, 20 Jun 2018 14:13:34 +0100 http://sro.sussex.ac.uk/id/eprint/76643/ http://sro.sussex.ac.uk/id/eprint/76643/ Gibson, Beth, Wilson, Daniel J, Feil, Edward and Eyre-Walker, Adam (2018) The distribution of bacterial doubling times in the wild. Proceedings of the Royal Society B: Biological Sciences, 285 (1880). 20180789 1-9. ISSN 0962-8452 Tue, 10 Apr 2018 14:39:03 +0100 http://sro.sussex.ac.uk/id/eprint/74971/ http://sro.sussex.ac.uk/id/eprint/74971/ Smith, Thomas C A, Arndt, Peter F and Eyre-Walker, Adam (2018) Large scale variation in the rate of germ-line de novo mutation, base composition, divergence and diversity in humans. PLoS Genetics, 14 (3). e1007254. ISSN 1553-7404 Thu, 23 Nov 2017 11:16:45 +0000 http://sro.sussex.ac.uk/id/eprint/71509/ http://sro.sussex.ac.uk/id/eprint/71509/ Krasovec, Marc, Eyre-Walker, Adam, Grimsley, Nigel, Salmeron, Christophe, Pecqueur, David, Piganeau, Gwenael and Sanchez-Ferandin, Sophie (2016) Fitness effects of spontaneous mutations in picoeukaryotic marine green algae. G3, 6 (7). pp. 2063-2071. ISSN 2160-1836 Wed, 15 Nov 2017 15:53:30 +0000 http://sro.sussex.ac.uk/id/eprint/71286/ http://sro.sussex.ac.uk/id/eprint/71286/ Baxter, Jon (2012) A model for chromosome condensation based on the interplay between condensin and topoisomerase II. Trends in Genetics, 28 (3). pp. 110-117. ISSN 0168-9525 Wed, 15 Nov 2017 15:27:41 +0000 http://sro.sussex.ac.uk/id/eprint/71282/ http://sro.sussex.ac.uk/id/eprint/71282/ Keszthelyi, Andrea, Minchell, Nicola and Baxter, Jon (2016) The causes and consequences of topological stress during DNA replication. Genes, 7 (12). p. 134. ISSN 2073-4425 Fri, 13 Oct 2017 11:11:56 +0100 http://sro.sussex.ac.uk/id/eprint/70496/ http://sro.sussex.ac.uk/id/eprint/70496/ Sacristan-Reviriego, Almudena, Bellingham, James, Prodromou, Chrisostomos, Kumaran, Neruban, Bainbridge, James, Michaelides, Michel and van der Spuy, Jacqueline (2017) The integrity and organization of the human AIPL1 functional domains is critical for its role as a HSP90-dependent co-chaperone for rod PDE6. Human Molecular Genetics, 26 (22). pp. 4465-4480. ISSN 0964-6906 Wed, 11 Oct 2017 13:15:40 +0100 http://sro.sussex.ac.uk/id/eprint/70487/ http://sro.sussex.ac.uk/id/eprint/70487/ Long, Christopher (2017) The molecularisation of security: medical countermeasure development and the Biomedical Advanced Research and Development Authority (BARDA), 2006-2015. Doctoral thesis (PhD), University of Sussex. Thu, 27 Jul 2017 13:29:44 +0100 http://sro.sussex.ac.uk/id/eprint/69495/ http://sro.sussex.ac.uk/id/eprint/69495/ Blanc-Mathieu, Romain, Krasovec, Marc, Hebrard, Maxime, Yau, Sheree, Desgranges, Elodie, Martin, Joel, Schackwitz, Wendy, Kuo, Alan, Salin, Gerald, Donnadieu, Cecile, Desdevises, Yves, Sanchez-Ferandin, Sophie, Moreau, Hervé, Rivals, Eric, Grigoriev, Igor V, Grimsley, Nigel, Eyre-Walker, Adam and Piganeau, Gwenael (2017) Population genomics of picophytoplankton unveils novel chromosome hypervariability. Science Advances, 3 (7). e1700239. ISSN 2375-2548 Thu, 27 Jul 2017 13:24:08 +0100 http://sro.sussex.ac.uk/id/eprint/69493/ http://sro.sussex.ac.uk/id/eprint/69493/ Krasovec, Marc, Eyre-Walker, Adam, Sanchez-Ferandin, Sophie and Piganeau, Gwenael (2017) Spontaneous mutation rate in the smallest photosynthetic eukaryotes. Molecular Biology and Evolution, 34 (7). pp. 1770-1779. ISSN 0737-4038 Wed, 07 Jun 2017 11:42:21 +0100 http://sro.sussex.ac.uk/id/eprint/68395/ http://sro.sussex.ac.uk/id/eprint/68395/ Guilliam, Thomas A (2017) An investigation into the role, recruitment, and regulation of PrimPol in DNA replication restart. Doctoral thesis (PhD), University of Sussex. Wed, 24 May 2017 09:57:55 +0100 http://sro.sussex.ac.uk/id/eprint/68212/ http://sro.sussex.ac.uk/id/eprint/68212/ Smith, Thomas C A (2017) Within genome variation of germ-line and somatic mutation. Doctoral thesis (PhD), University of Sussex. Wed, 24 May 2017 08:31:58 +0100 http://sro.sussex.ac.uk/id/eprint/68211/ http://sro.sussex.ac.uk/id/eprint/68211/ Kirk, Jacob Daniel (2017) Understanding the roles of the Smc5/6 complex on meiotic recombination. Doctoral thesis (PhD), University of Sussex. Fri, 31 Mar 2017 09:42:18 +0100 http://sro.sussex.ac.uk/id/eprint/67231/ http://sro.sussex.ac.uk/id/eprint/67231/ Eyre-Walker, Adam (2017) Mitochondrial replacement therapy: are mito-nuclear interactions likely to be a problem? Genetics, 205 (4). pp. 1365-1372. ISSN 0016-6731 Mon, 27 Mar 2017 13:36:38 +0100 http://sro.sussex.ac.uk/id/eprint/67185/ http://sro.sussex.ac.uk/id/eprint/67185/ West, Michelle and Farrell, Paul (2017) Roles of RUNX in B cell immortalisation. In: Groner Yoram, Yoram, Ito, Yoshiaki, Liu, Paul, Neil, James, Speck, Nancy and van Wijnen, Andre (eds.) RUNX proteins in development and cancer. Advances in experimental medicine and biology, 962 . Springer Singapore, pp. 283-298. ISBN 9789811032318 Wed, 15 Feb 2017 11:00:36 +0000 http://sro.sussex.ac.uk/id/eprint/66775/ http://sro.sussex.ac.uk/id/eprint/66775/ Cooper, Simon J (2017) Investigating the role of FMRP, CYFIP1 and DDX3X in the processes of mRNA localisation and translation within mesenchymal cells. Doctoral thesis (PhD), University of Sussex. Wed, 16 Nov 2016 14:31:10 +0000 http://sro.sussex.ac.uk/id/eprint/65512/ http://sro.sussex.ac.uk/id/eprint/65512/ James, J, Castellano, D and Eyre-Walker, A (2016) DNA sequence diversity and the efficiency of natural selection in animal mitochondrial DNA. Heredity, 2017 (118). pp. 88-95. ISSN 0018-067X Tue, 15 Nov 2016 14:59:02 +0000 http://sro.sussex.ac.uk/id/eprint/40540/ http://sro.sussex.ac.uk/id/eprint/40540/ Valente, Enza Maria, Abou-Sleiman, Patrick M, Caputo, Viviana, Muqit, Miratul M K, Harvey, Kirsten, Gispert, Suzana, Ali, Zeeshan, Del Turco, Domenico, Bentivoglio, Anna Rita, Healy, Daniel G, Albanese, Alberto, Nussbaum, Robert, González-Maldonado, Rafael, Deller, Thomas, Salvi, Sergio, Cortelli, Pietro, Gilks, William P, Latchman, David S, Harvey, Robert J, Dallapiccola, Bruno, Auburger, Georg and Wood, Nicholas W (2004) Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science, 304 (5674). pp. 1158-60. ISSN 1095-9203 Mon, 14 Nov 2016 12:04:58 +0000 http://sro.sussex.ac.uk/id/eprint/65434/ http://sro.sussex.ac.uk/id/eprint/65434/ Kim, Leo Dhohoon (2016) Visualizing discourses and governance of human embryonic stem cell research in South Korea (in comparison to the UK). Doctoral thesis (PhD), University of Sussex. Wed, 09 Nov 2016 15:55:02 +0000 http://sro.sussex.ac.uk/id/eprint/65392/ http://sro.sussex.ac.uk/id/eprint/65392/ Gilks, William P, Pennell, Tanya M, Flis, Ilona, Webster, Matthew T and Morrow, Edward H (2016) Whole genome resequencing of a laboratory-adapted Drosophila melanogaster population sample. F1000Research, 5. a2644. ISSN 2046-1402 Thu, 22 Sep 2016 11:19:33 +0100 http://sro.sussex.ac.uk/id/eprint/63526/ http://sro.sussex.ac.uk/id/eprint/63526/ Towler, Benjamin P, Jones, Christopher I, Harper, Kirsty L, Waldron, Joseph A and Newbury, Sarah F (2016) A novel role for the 3′-5′ exoribonuclease Dis3L2 in controlling cell proliferation and tissue growth. RNA Biology, 13 (12). pp. 1286-1299. ISSN 1547-6286 Tue, 20 Sep 2016 11:40:22 +0100 http://sro.sussex.ac.uk/id/eprint/63434/ http://sro.sussex.ac.uk/id/eprint/63434/ Smith, Thomas C A, Carr, Antony M and Eyre-Walker, Adam C (2016) Are sites with multiple single nucleotide variants in cancer genomes a consequence of drivers, hypermutable sites or sequencing errors? PeerJ, 4. e2391 1-15. ISSN 2167-8359 Thu, 28 Jul 2016 08:41:20 +0100 http://sro.sussex.ac.uk/id/eprint/62133/ http://sro.sussex.ac.uk/id/eprint/62133/ Richardson, Joanna and Simpson, Pat (2006) A conserved trans-regulatory landscape for scute expression on the notum of cyclorraphous Diptera. Development Genes and Evolution, 216 (1). pp. 29-38. ISSN 0949-944X Thu, 28 Jul 2016 08:34:20 +0100 http://sro.sussex.ac.uk/id/eprint/62131/ http://sro.sussex.ac.uk/id/eprint/62131/ McGonnell, Imelda M, Graham, Anthony, Richardson, Joanna, Fish, Jennifer L, Depew, Michael J, Dee, Chris T, Holland, Peter WH and Takahashi, Tokiharu (2011) Evolution of the Alx homeobox gene family: parallel retention and independent loss of the vertebrate Alx3 gene. Evolution and Development, 13 (4). pp. 343-351. ISSN 1520-541X Fri, 17 Jun 2016 14:26:09 +0100 http://sro.sussex.ac.uk/id/eprint/61484/ http://sro.sussex.ac.uk/id/eprint/61484/ Patraquim, Pedro Miguel Queirós do Patrocínio (2016) Molecular and developmental impact of RNA processing on mammalian Hox genes. Doctoral thesis (PhD), University of Sussex. Fri, 22 Apr 2016 09:42:41 +0100 http://sro.sussex.ac.uk/id/eprint/60057/ http://sro.sussex.ac.uk/id/eprint/60057/ Pennell, Tanya Marie (2016) The evolutionary dynamics of intralocus sexual conflict. Doctoral thesis (PhD), University of Sussex. Mon, 11 Apr 2016 08:27:29 +0100 http://sro.sussex.ac.uk/id/eprint/60404/ http://sro.sussex.ac.uk/id/eprint/60404/ Etheridge, Thomas James (2016) Application of photoactivated localisation microscopy to visualising eukaryotic DNA replication processes. Doctoral thesis (PhD), University of Sussex. Fri, 18 Mar 2016 11:16:37 +0000 http://sro.sussex.ac.uk/id/eprint/60084/ http://sro.sussex.ac.uk/id/eprint/60084/ Smith, Thomas, Ho, Gladys, Christodoulou, John, Price, Elizabeth Ann, Onadim, Zerrin, Gauthier-Villars, Marion, Dehainault, Catherine, Houdayer, Claude, Parfait, Beatrice, van Minkelen, Rick, Lohman, Dietmar and Eyre-Walker, Adam (2016) Extensive variation in the mutation rate between and within human genes associated with Mendelian disease. Human Mutation, 37 (5). pp. 488-494. ISSN 1059-7794 Wed, 02 Mar 2016 11:41:47 +0000 http://sro.sussex.ac.uk/id/eprint/59799/ http://sro.sussex.ac.uk/id/eprint/59799/ Mallo, Moisés and Alonso, Claudio R (2013) The regulation of Hox gene expression during animal development. Development, 140 (19). pp. 3951-3963. ISSN 0950-1991 Fri, 15 Jan 2016 13:45:46 +0000 http://sro.sussex.ac.uk/id/eprint/59194/ http://sro.sussex.ac.uk/id/eprint/59194/ Costa, Marta, Calleja, Manuel, Alonso, Claudio R and Simpson, Pat (2014) The bristle patterning genes hairy and extramacrochaetae regulate the development of structures required for flight in Diptera. Developmental Biology, 388 (2). pp. 205-215. ISSN 0012-1606 Fri, 15 Jan 2016 12:49:31 +0000 http://sro.sussex.ac.uk/id/eprint/59179/ http://sro.sussex.ac.uk/id/eprint/59179/ Casadio, Angela, Longman, Dasa, Hug, Nele, Delavaine, Laurent, Vallejos Baier, Raul, Alonso, Claudio R and Caceres, Javier F (2015) Identification and characterization of novel factors that act in the nonsense-mediated mRNA decay pathway in nematodes, flies and mammals. EMBO reports, 16 (1). pp. 71-78. ISSN 1469-221X Fri, 15 Jan 2016 10:03:50 +0000 http://sro.sussex.ac.uk/id/eprint/59188/ http://sro.sussex.ac.uk/id/eprint/59188/ Tyler-Smith, Chris, Chipman, Ariel D, Ferrier, David E K, Brena, Carlo, Qu, Jiaxin, Hughes, Daniel S T, Schröder, Reinhard, Torres-Oliva, Montserrat, Znassi, Nadia, Jiang, Huaiyang, Almeida, Francisca C, Alonso, Claudio R, Apostolou, Zivkos, Aqrawi, Peshtewani, Arthur, Wallace, Barna, Jennifer C J, Blankenburg, Kerstin P, Brites, Daniela, Capella-Gutiérrez, Salvador, Coyle, Marcus, Dearden, Peter K, Du Pasquier, Louis, Duncan, Elizabeth J, Ebert, Dieter, Eibner, Cornelius, Erikson, Galina, Evans, Peter D, Extavour, Cassandra G, Francisco, Liezl, Gabaldón, Toni, Gillis, William J, Goodwin-Horn, Elizabeth A, Green, Jack E, Griffiths-Jones, Sam, Grimmelikhuijzen, Cornelis J P, Gubbala, Sai, Guigó, Roderic, Han, Yi, Hauser, Frank, Havlak, Paul, Hayden, Luke, Helbing, Sophie, Holder, Michael, Hui, Jerome H L, Hunn, Julia P, Hunnekuhl, Vera S, Jackson, LaRonda, Javaid, Mehwish, Jhangiani, Shalini N, Jiggins, Francis M, Jones, Tamsin E, Kaiser, Tobias S, Kalra, Divya, Kenny, Nathan J, Korchina, Viktoriya, Kovar, Christie L, Kraus, F. Bernhard, Lapraz, François, Lee, Sandra L, Lv, Jie, Mandapat, Christigale, Manning, Gerard, Mariotti, Marco, Mata, Robert, Mathew, Tittu, Neumann, Tobias, Newsham, Irene, Ngo, Dinh N, Ninova, Maria, Okwuonu, Geoffrey, Ongeri, Fiona, Palmer, William J, Patil, Shobha, Patraquim, Pedro, Pham, Christopher, Pu, Ling-Ling, Putman, Nicholas H, Rabouille, Catherine, Ramos, Olivia Mendivil, Rhodes, Adelaide C, Robertson, Helen E, Robertson, Hugh M, Ronshaugen, Matthew, Rozas, Julio, Saada, Nehad, Sánchez-Gracia, Alejandro, Scherer, Steven E, Schurko, Andrew M, Siggens, Kenneth W, Simmons, DeNard, Stief, Anna, Stolle, Eckart, Telford, Maximilian J, Tessmar-Raible, Kristin, Thornton, Rebecca, van der Zee, Maurijn, von Haeseler, Arndt, Williams, James M, Willis, Judith H, Wu, Yuanqing, Zou, Xiaoyan, Lawson, Daniel, Muzny, Donna M, Worley, Kim C, Gibbs, Richard A, Akam, Michael and Richards, Stephen (2014) The first myriapod genome sequence reveals conservative arthropod gene content and genome organisation in the centipede Strigamia maritima. PLoS Biology, 12 (11). e1002005 1-24. ISSN 1545-7885 Tue, 12 Jan 2016 12:38:16 +0000 http://sro.sussex.ac.uk/id/eprint/59107/ http://sro.sussex.ac.uk/id/eprint/59107/ Jones, Christopher I, Pashler, Amy L, Towler, Benjamin P, Robinson, Sophie R and Newbury, Sarah F (2016) RNA-seq reveals post-transcriptional regulation of Drosophila insulin-like peptide dilp8 and the neuropeptide-like precursor Nplp2 by the exoribonuclease Pacman/XRN1. Nucleic Acids Research, 44 (1). pp. 267-280. ISSN 0305-1048 Mon, 11 Jan 2016 15:52:02 +0000 http://sro.sussex.ac.uk/id/eprint/59079/ http://sro.sussex.ac.uk/id/eprint/59079/ Towler, Benjamin P, Jones, Christopher I and Newbury, Sarah F (2015) Mechanisms of regulation of mature miRNAs. Biochemical Society Transactions, 43 (6). pp. 1208-1214. ISSN 0300-5127 Thu, 04 Jun 2015 14:42:55 +0100 http://sro.sussex.ac.uk/id/eprint/54095/ http://sro.sussex.ac.uk/id/eprint/54095/ Keen, Benjamin A (2015) Molecular dissection of PrimPol, a novel primase-polymerase involved in damage tolerance during DNA replication in eukaryotic cells. Doctoral thesis (PhD), University of Sussex. Tue, 14 Apr 2015 08:30:45 +0100 http://sro.sussex.ac.uk/id/eprint/53661/ http://sro.sussex.ac.uk/id/eprint/53661/ Towler, Benjamin P, Jones, Christopher I, Viegas, Sandra C, Apura, Patricia, Waldron, Joseph A, Smalley, Sarah K, Arraiano, Cecilia M and Newbury, Sarah F (2015) The 3’-5’ exoribonuclease Dis3 regulates the expression of specific microRNAs in Drosophila wing imaginal discs. RNA Biology, 12 (7). pp. 728-741. ISSN 1547-6286 Wed, 25 Feb 2015 10:29:24 +0000 http://sro.sussex.ac.uk/id/eprint/44382/ http://sro.sussex.ac.uk/id/eprint/44382/ Truman, Andrew W, Millson, Stefan H, Nuttall, James M, King, Victoria, Mollapour, Medhi, Prodromou, Chrisostomos, Pearl, Laurence H and Piper, Peter W (2006) Expressed in the yeast Saccharomyces cerevisiae, human ERK5 is a client of the Hsp90 chaperone that complements loss of the Slt2p (Mpk1p) cell integrity stress-activated protein kinase. Eukaryotic Cell, 5 (11). pp. 1914-1924. ISSN 1535-9778 Wed, 25 Feb 2015 08:55:58 +0000 http://sro.sussex.ac.uk/id/eprint/44356/ http://sro.sussex.ac.uk/id/eprint/44356/ Piper, Peter W, Panaretou, Barry, Millson, Stefan H, Truman, Andrew, Mollapour, Mehdi, Pearl, Laurence and Prodromou, Chrisostomos (2003) Yeast is selectively hypersensitised to heat shock protein 90 (Hsp90)-targetting drugs with heterologous expression of the human Hsp90beta, a property that can be exploited in screens for new Hsp90 chaperone inhibitors. Gene, 302 (1-2). pp. 165-170. ISSN 0378-1119 Wed, 25 Feb 2015 08:43:54 +0000 http://sro.sussex.ac.uk/id/eprint/44355/ http://sro.sussex.ac.uk/id/eprint/44355/ Piper, Peter W, Millson, Stefan H, Mollapour, Mehdi, Panaretou, Barry, Siligardi, Giuliano, Pearl, Laurence H and Prodromou, Chrisostomos (2003) Sensitivity to Hsp90-targeting drugs can arise with mutation to the Hsp90 chaperone, cochaperones and plasma membrane ATP binding cassette transporters of yeast. European Journal of Biochemistry, 270 (23). pp. 4689-4695. ISSN 0014-2956 Wed, 25 Feb 2015 07:25:56 +0000 http://sro.sussex.ac.uk/id/eprint/44350/ http://sro.sussex.ac.uk/id/eprint/44350/ Panaretou, Barry, Sinclair, Kirsty, Prodromou, Chrisostomos, Johal, Jasvinder, Pearl, Laurence and Piper, Peter W (1999) The Hsp90 of Candida albicans can confer Hsp90 functions in Saccharomyces cerevisiae: a potential model for the processes that generate immunogenic fragments of this molecular chaperone in C. albicans infections. Microbiology, 145 (12). pp. 3455-3463. ISSN 1350-0872 Wed, 25 Feb 2015 07:18:42 +0000 http://sro.sussex.ac.uk/id/eprint/44349/ http://sro.sussex.ac.uk/id/eprint/44349/ Panaretou, Barry, Siligardi, Giuliana, Meyer, Philippe, Maloney, Alison, Sullivan, Janis K, Singh, Shradha, Millson, Stefan H, Clarke, Paul A, Naaby-Hansen, Soren, Stein, Rob, Cramer, Rainer, Mollapour, Mehdi, Workman, Paul, Piper, Peter W, Pearl, Laurence H and Prodromou, Chrisostomos (2002) Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1. Molecular Cell, 10 (6). pp. 1307-1318. ISSN 1097-2765 Wed, 25 Feb 2015 07:13:50 +0000 http://sro.sussex.ac.uk/id/eprint/44348/ http://sro.sussex.ac.uk/id/eprint/44348/ Panaretou, Barry, Prodromou, Chrisostomos, Roe, S Mark, O'Brien, Ronan, Ladbury, John E, Piper, Peter W and Pearl, Laurence H (1998) ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo. EMBO Journal, 17 (16). pp. 4829-4836. ISSN 0261-4189 Wed, 25 Feb 2015 07:11:35 +0000 http://sro.sussex.ac.uk/id/eprint/44344/ http://sro.sussex.ac.uk/id/eprint/44344/ Millson, Stefan H, Truman, Andrew W, Wolfram, Francis, King, Victoria, Panaretou, Barry, Prodromou, Chrisostomos, Pearl, Laurence H and Piper, Peter W (2004) Investigating the protein-protein interactions of the yeast Hsp90 chaperone system by two-hybrid analysis: potential uses and limitations of this approach. Cell Stress and Chaperones, 9 (4). pp. 359-368. ISSN 1355-8145 Wed, 25 Feb 2015 07:08:35 +0000 http://sro.sussex.ac.uk/id/eprint/44343/ http://sro.sussex.ac.uk/id/eprint/44343/ Millson, Stefan H, Truman, Andrew W, King, Victoria, Prodromou, Chrisostomos, Pearl, Laurence H and Piper, Peter W (2005) A two-hybrid screen of the yeast proteome for Hsp90 interactors uncovers a novel Hsp90 chaperone requirement in the activity of a stress-activated mitogen-activated protein kinase, Slt2p (Mpk1p). Eukaryotic Cell, 4 (5). pp. 849-860. ISSN 1535-9778 Wed, 25 Feb 2015 06:56:34 +0000 http://sro.sussex.ac.uk/id/eprint/44338/ http://sro.sussex.ac.uk/id/eprint/44338/ Hu, Bin, Liao, Chunyan, Millson, Stefan H, Mollapour, Mehdi, Prodromou, Chrisostomos, Pearl, Laurence H, Piper, Peter W and Panaretou, Barry (2005) Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex. Molecular Microbiology, 55 (6). pp. 1735-1750. ISSN 0950-382X Tue, 24 Feb 2015 17:57:26 +0000 http://sro.sussex.ac.uk/id/eprint/44368/ http://sro.sussex.ac.uk/id/eprint/44368/ Prodromou, C, Wright, I P, Evans, I H and Bevan, E A (1991) Cloning of the HIS3 gene of Yarrowia lipolytica. Antonie Van Leeuwenhoek, 60 (2). pp. 95-99. ISSN 0003-6072 Tue, 24 Feb 2015 15:37:18 +0000 http://sro.sussex.ac.uk/id/eprint/44383/ http://sro.sussex.ac.uk/id/eprint/44383/ Truman, Andrew W, Millson, Stefan H, Nuttall, James M, Mollapour, Mehdi, Prodromou, Chrisostomos and Piper, Peter W (2007) In the yeast heat shock response, Hsf1-directed induction of Hsp90 facilitates the activation of the Slt2 (Mpk1) mitogen-activated protein kinase required for cell integrity. Eukaryotic Cell, 6 (4). pp. 744-752. ISSN 1535-9778 Tue, 17 Feb 2015 07:39:26 +0000 http://sro.sussex.ac.uk/id/eprint/52959/ http://sro.sussex.ac.uk/id/eprint/52959/ Edelweiss Villava Robles, Casandra (2015) The molecular regulation of Hox gene RNA processing during Drosophila embryonic development. Doctoral thesis (PhD), University of Sussex. Tue, 27 Jan 2015 13:04:30 +0000 http://sro.sussex.ac.uk/id/eprint/52499/ http://sro.sussex.ac.uk/id/eprint/52499/ Mohebi, Saed (2014) Analysis of chromosomal rearrangements after replication restart. Doctoral thesis (PhD), University of Sussex. Thu, 08 Jan 2015 09:33:25 +0000 http://sro.sussex.ac.uk/id/eprint/51924/ http://sro.sussex.ac.uk/id/eprint/51924/ Herbert, Alex D, Carr, Antony M and Hoffmann, Eva (2014) FindFoci: a focus detection algorithm with automated parameter training that closely matches human assignments, reduces human inconsistencies and increases speed of analysis. PLoS ONE, 9 (12). e114749. ISSN 1932-6203 Tue, 29 Jul 2014 08:22:18 +0100 http://sro.sussex.ac.uk/id/eprint/49422/ http://sro.sussex.ac.uk/id/eprint/49422/ Kakarougkas, Andreas, Ismail, Amani, Chambers, Anna, Riballo, Queti, Herbert, Alex, Kunzel, Julia, Lobrich, Markus, Jeggo, Penny and Downs, Jessica (2014) Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin. Molecular Cell, 55 (5). pp. 723-732. ISSN 1097-2765 Fri, 11 Jul 2014 08:47:24 +0100 http://sro.sussex.ac.uk/id/eprint/49133/ http://sro.sussex.ac.uk/id/eprint/49133/ Machin, Felix, Torres-Rosell, Jordi, De Piccoli, Giacomo, Carballo, Jesus, Cha, Rita, Jarmuz, Adam and Aragon, Luis (2006) Transcription of ribosomal genes can cause nondisjunction. The Journal of Cell Biology (JCB), 173 (6). pp. 893-903. ISSN 0021-9525 Fri, 11 Jul 2014 07:25:54 +0100 http://sro.sussex.ac.uk/id/eprint/49243/ http://sro.sussex.ac.uk/id/eprint/49243/ Carballo, Jesús A, Panizza, Silvia, Serrentino, Maria Elisabetta, Johnson, Anthony L, Geymonat, Marco, Borde, Valérie, Klein, Franz and Cha, Rita S (2013) Budding yeast ATM/ATR control meiotic double-strand break (DSB) levels by down-regulating Rec114, an essential component of the DSB-machinery. PLoS Genetics, 9 (6). e1003545. ISSN 1553-7390 Fri, 11 Jul 2014 07:14:31 +0100 http://sro.sussex.ac.uk/id/eprint/49244/ http://sro.sussex.ac.uk/id/eprint/49244/ Carballo, Jesús A, Johnson, Anthony L, Sedgwick, Steven G and Cha, Rita S (2008) Phosphorylation of the axial element protein Hop1 by Mec1/Tel1 ensures meiotic interhomolog recombination. Cell, 132 (5). pp. 758-770. ISSN 0092-8674 Fri, 11 Jul 2014 07:11:09 +0100 http://sro.sussex.ac.uk/id/eprint/49245/ http://sro.sussex.ac.uk/id/eprint/49245/ Carballo, Jesús A and Cha, Rita S (2007) Meiotic roles of Mec1, a budding yeast homolog of mammalian ATR/ATM. Chromosome Research, 15 (5). pp. 539-550. ISSN 0967-3849 Tue, 17 Jun 2014 06:42:14 +0100 http://sro.sussex.ac.uk/id/eprint/46774/ http://sro.sussex.ac.uk/id/eprint/46774/ Gaysina, Darya, Cohen-Woods, Sarah, Chow, Philip C, Martucci, Livia, Schosser, Alexandra, Ball, Harriet A, Tozzi, Federica, Perry, Julia, Muglia, Pierandrea, Kennedy, James L, King, Nicole, Vincent, John B, Parikh, Sagar V, Strauss, John, Craig, Ian W, McGuffin, Peter and Farmer, Anne (2010) Association analysis of DAOA and DAO in bipolar disorder: results from two independent case-control studies. Bipolar Disorders, 12 (5). pp. 579-581. ISSN 1398-5647 Tue, 17 Jun 2014 06:39:54 +0100 http://sro.sussex.ac.uk/id/eprint/46773/ http://sro.sussex.ac.uk/id/eprint/46773/ Schosser, Alexandra, Pirlo, Katrina, Gaysina, Darya, Cohen-Woods, Sarah, Schalkwyk, Leonard C, Elkin, Amanda, Korszun, Ania, Gunasinghe, Cerisse, Gray, Joanna, Jones, Lisa, Meaburn, Emma, Farmer, Anne E, Craig, Ian W and McGuffin, Peter (2010) Utility of the pooling approach as applied to whole genome association scans with high-density Affymetrix microarrays. BMC Research Notes, 3 (1). p. 274. ISSN 1756-0500 Thu, 05 Jun 2014 13:18:08 +0100 http://sro.sussex.ac.uk/id/eprint/48855/ http://sro.sussex.ac.uk/id/eprint/48855/ Ahmed, Jubed Omee (2014) Characterisation of the roles of Poz1 and Stn1 at Schizosaccharomyces pombe telomeres. Doctoral thesis (PhD), University of Sussex. Tue, 11 Feb 2014 15:48:42 +0000 http://sro.sussex.ac.uk/id/eprint/47517/ http://sro.sussex.ac.uk/id/eprint/47517/ Lee, Chieh-Ju (2014) Visualizing chromosomal rearrangements caused by replication fork stalling in a single cell. Doctoral thesis (PhD), University of Sussex. Tue, 26 Nov 2013 14:38:08 +0000 http://sro.sussex.ac.uk/id/eprint/46460/ http://sro.sussex.ac.uk/id/eprint/46460/ Roberts, Terri Patricia (2013) Developmental failure in cochlear hair cells from mouse models of Usher syndrome and the identification of an acid sensitive ionic current in Inner and Outer hair cells. Doctoral thesis (PhD), University of Sussex. Fri, 01 Nov 2013 07:34:58 +0000 http://sro.sussex.ac.uk/id/eprint/46829/ http://sro.sussex.ac.uk/id/eprint/46829/ Vesely, Clare (2013) Investigation of the mechanisms of the G2/M phase transition in human cells – the role of Greatwall kinase. Doctoral thesis (PhD), University of Sussex. Tue, 22 Oct 2013 08:34:47 +0100 http://sro.sussex.ac.uk/id/eprint/46775/ http://sro.sussex.ac.uk/id/eprint/46775/ Cohen-Woods, Sarah, Craig, Ian, Gaysina, Darya and et al, (2010) The Bipolar Association case-control study (BACCS) and meta-analysis: no association with the 5,10-Methylenetetrahydrofolate reductase gene and bipolar disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 153B (7). pp. 1298-1304. ISSN 1552-4841 Tue, 08 Oct 2013 11:06:13 +0100 http://sro.sussex.ac.uk/id/eprint/46508/ http://sro.sussex.ac.uk/id/eprint/46508/ Schosser, A, Gaysina, D, Cohen-Woods, S, Domenici, E, Perry, J, Tozzi, F, Korszun, A, Gunasinghe, C, Gray, J, Jones, L, Binder, E B, Holsboer, F, Craddock, N, Owen, M J, Craig, I W, Farmer, A E, Muglia, P and McGuffin, P (2011) A follow-up case-control association study of tractable (druggable) genes in recurrent major depression. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 156 (6). pp. 640-650. ISSN 1552-4841 Tue, 08 Oct 2013 11:03:24 +0100 http://sro.sussex.ac.uk/id/eprint/46611/ http://sro.sussex.ac.uk/id/eprint/46611/ Schosser, A, Cohen-Woods, S, Gaysina, D, Chow, P C, Martucci, L, Farmer, A, Korszun, A, Gunashinghe, C, Gray, J, Jones, L, Craddock, N, Owen, M J, Craig, I W and McGuffin, P (2010) NRG1gene in recurrent major depression: No association in a large-scale case-control association study. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 153B (1). pp. 141-147. ISSN 1552-4841 Tue, 08 Oct 2013 10:53:48 +0100 http://sro.sussex.ac.uk/id/eprint/46609/ http://sro.sussex.ac.uk/id/eprint/46609/ Schosser, A, Gaysina, D, Cohen-Woods, S, Chow, P C, Martucci, L, Craddock, N, Farmer, A, Korszun, A, Gunasinghe, C, Gray, J, Jones, L, Tozzi, F, Perry, J, Muglia, P, Owen, M J, Craig, I W and McGuffin, P (2010) Association of DISC1 and TSNAX genes and affective disorders in the depression case–control (DeCC) and bipolar affective case–control (BACCS) studies. Molecular Psychiatry, 15 (8). pp. 844-849. ISSN 1359-4184 Tue, 24 Sep 2013 14:12:22 +0100 http://sro.sussex.ac.uk/id/eprint/46135/ http://sro.sussex.ac.uk/id/eprint/46135/ Carroll, Jean (2013) Investigating aprataxin function: roles in DNA single strand break repair and functional cellular effects. Doctoral thesis (PhD), University of Sussex. Thu, 22 Aug 2013 14:18:37 +0100 http://sro.sussex.ac.uk/id/eprint/45543/ http://sro.sussex.ac.uk/id/eprint/45543/ Rudd, Sean G (2013) Cellular and biochemical characterisation of PrimPol, a novel eukaryotic primase-polymerase involved in DNA damage tolerance. Doctoral thesis (PhD), University of Sussex. Thu, 22 Aug 2013 12:26:29 +0100 http://sro.sussex.ac.uk/id/eprint/45544/ http://sro.sussex.ac.uk/id/eprint/45544/ Bianchi, Julie (2013) Investigating the role of a novel primase-polymerase, PrimPol, in DNA damage tolerance in vertebrate cells. Doctoral thesis (PhD), University of Sussex. Fri, 28 Jun 2013 11:49:11 +0100 http://sro.sussex.ac.uk/id/eprint/45246/ http://sro.sussex.ac.uk/id/eprint/45246/ Alcantara, Diana (2013) Understanding at the molecular level the consequences of defective ATR signalling in humans. Doctoral thesis (PhD), University of Sussex. Mon, 20 May 2013 11:42:10 +0100 http://sro.sussex.ac.uk/id/eprint/44722/ http://sro.sussex.ac.uk/id/eprint/44722/ Zimmerman, Kristin Mara (2013) The cellular impact of diminished DNA origin licensing capacity and its potential therapeutic exploitation. Doctoral thesis (PhD), University of Sussex. Mon, 11 Feb 2013 14:07:12 +0000 http://sro.sussex.ac.uk/id/eprint/43584/ http://sro.sussex.ac.uk/id/eprint/43584/ Lukas, Claudia, Savic, Velibor, Bekker-Jensen, Simon, Doil, Carsten, Neumann, Beate, Pedersen, Ronni Sølvhøj, Grøfte, Merete, Chan, Kok Lung, Hickson, Ian David, Bartek, Jiri and Lukas, Jiri (2011) 53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress. Nature Cell Biology, 13 (3). pp. 243-253. ISSN 1465-7392 Mon, 11 Feb 2013 14:02:11 +0000 http://sro.sussex.ac.uk/id/eprint/43580/ http://sro.sussex.ac.uk/id/eprint/43580/ Loomis, Rebecca J, Naoe, Yoshinori, Parker, J Brandon, Savic, Velibor, Bozovsky, Matthew R, Macfarlan, Todd, Manley, James L and Chakravarti, Debabrata (2009) Chromatin binding of SRp20 and ASF/SF2 and dissociation from mitotic chromosomes is modulated by histone H3 serine 10 phosphorylation. Molecular Cell, 33 (4). pp. 450-461. ISSN 1097-2765 Thu, 01 Nov 2012 11:21:41 +0000 http://sro.sussex.ac.uk/id/eprint/41768/ http://sro.sussex.ac.uk/id/eprint/41768/ Lin, Su-Jiun, Wardlaw, Christopher Paul, Morishita, Takashi, Miyabe, Izumi, Chahwan, Charly, Caspari, Thomas, Schmidt, Ulrike, Carr, Antony and Garcia, Valerie (2012) The Rad4TopBP1 ATR-Activation domain functions in G1/S phase in a chromatin-dependent manner. PLoS Genetics, 8 (6). ISSN 1553-7390 Fri, 18 May 2012 08:42:23 +0100 http://sro.sussex.ac.uk/id/eprint/38853/ http://sro.sussex.ac.uk/id/eprint/38853/ Schalbetter, Stephanie (2012) Genome instability induced by structured DNA and replication fork restart. Doctoral thesis (DPhil), University of Sussex. Tue, 20 Mar 2012 15:39:16 +0000 http://sro.sussex.ac.uk/id/eprint/38117/ http://sro.sussex.ac.uk/id/eprint/38117/ Khosravi, Mona (2012) ‘Investigating the regulation of growth by nitric oxide signalling in Drosophila melanogaster’. Doctoral thesis (DPhil), University of Sussex. Thu, 23 Feb 2012 13:36:43 +0000 http://sro.sussex.ac.uk/id/eprint/38114/ http://sro.sussex.ac.uk/id/eprint/38114/ Alamri, Ohoud (2012) Ionising radiation-induced DNA damage response in marine mussels, Mytilus edulis. Doctoral thesis (DPhil), University of Sussex. Fri, 10 Feb 2012 10:04:50 +0000 http://sro.sussex.ac.uk/id/eprint/7626/ http://sro.sussex.ac.uk/id/eprint/7626/ Reynolds, John Joseph (2012) Investigating the link between defective DNA end-processing and human neurological disease. Doctoral thesis (DPhil), University of Sussex. Fri, 18 Nov 2011 11:48:11 +0000 http://sro.sussex.ac.uk/id/eprint/7200/ http://sro.sussex.ac.uk/id/eprint/7200/ Cloney, Ross (2011) Involvement of human DNA polymerase kappa in nucleotide excision repair. Doctoral thesis (DPhil), University of Sussex. Tue, 18 Oct 2011 09:39:52 +0100 http://sro.sussex.ac.uk/id/eprint/7420/ http://sro.sussex.ac.uk/id/eprint/7420/ Bettini, Natalia (2011) NOS-related natural antisense transcripts: sequence analysis and characterization of expression. Doctoral thesis (DPhil), University of Sussex. Thu, 01 Sep 2011 07:57:26 +0100 http://sro.sussex.ac.uk/id/eprint/7349/ http://sro.sussex.ac.uk/id/eprint/7349/ Hodgkinson, Alan James (2011) Patterns of mutation in the human genome. Doctoral thesis (DPhil), University of Sussex. Tue, 16 Aug 2011 10:24:08 +0100 http://sro.sussex.ac.uk/id/eprint/7222/ http://sro.sussex.ac.uk/id/eprint/7222/ Burton, Paul R., Clayton, David G., Cardon, Lon R., Craddock, Nick, Deloukas, Panos, Duncanson, Audrey, Kwiatkowski, Dominic P., McCarthy, Mark I., Ouwehand, Willem H., Samani, Nilesh J., Todd, John A., Donnelly, Peter, Barrett, Jeffrey C., Davison, Dan, Easton, Doug, Evans, David, Leung, Hin-Tak, Marchini, Jonathan L., Morris, Andrew P., Spencer, Chris C.A., Tobin, Martin D., Attwood, Antony P., Boorman, James P., Cant, Barbara, Everson, Ursula, Hussey, Judith M., Jolley, Jennifer D., Knight, Alexandra S., Koch, Kerstin, Meech, Elizabeth, Nutland, Sarah, Prowse, Christopher V., Stevens, Helen E., Taylor, Niall C., Walters, Graham R., Walker, Neil M., Watkins, Nicholas A., Winzer, Thilo, Jones, Richard W., McArdle, Wendy L., Ring, Susan M., Strachan, David P., Pembrey, Marcus, Breen, Gerome, St Clair, David, Caesar, Sian, Gordon-Smith, Katherine, Jones, Lisa, Fraser, Christine, Green, Elain K., Grozeva, Detelina, Hamshere, Marian L., Holmans, Peter A., Jones, Ian R., Kirov, George, Moskvina, Valentina, Nikolov, Ivan, O'Donovan, Michael C., Owen, Michael J., Collier, David A., Elkin, Amanda, Farmer, Anne, Williamson, Richard, McGuffin, Peter, Young, Allan H., Ferrier, I. Nicol, Ball, Stephen G., Balmforth, Anthony J., Barrett, Jennifer H., Bishop, D. Timothy, Iles, Mark M., Maqbool, Azhar, Yuldasheva, Nadira, Hall, Alistair S., Braund, Peter S., Dixon, Richard J., Mangino, Massimo, Stevens, Suzanne, Thompson, John R., Bredin, Francesca, Tremelling, Mark, Parkes, Miles, Drummond, Hazel, Lees, Charles W., Nimmo, Elaine R., Satsangi, Jack, Fisher, Sheila A., Forbes, Alistair, Lewis, Cathryn M., Onnie, Clive M., Prescott, Natalie J., Sanderson, Jeremy, Mathew, Christopher G., Barbour, Jamie, Mohiuddin, M. Khalid, Todhunter, Catherine E., Mansfield, John C., Ahmad, Tariq, Cummings, Fraser R., Jewell, Derek P., Webster, John, Brown, Morris J., Lathrop, G. Mark, Connell, John, Dominiczak, Anna, Marcano, Carolina A. Braga, Burke, Beverley, Dobson, Richard, Gungadoo, Johannie, Lee, Kate L., Munroe, Patricia B., Newhouse, Stephen J., Onipinla, Abiodun, Wallace, Chris, Xue, Mingzhan, Caulfield, Mark, Farrall, Martin, Barton, Anne, Bruce, Ian N., Donovan, Hannah, Eyre, Steve, Gilbert, Paul D., Hider, Samantha L., Hinks, Anne M., John, Sally L., Potter, Catherine, Silman, Alan J., Symmons, Deborah P. M., Thomson, Wendy, Worthington, Jane, Dunger, David B., Widmer, Barry, Frayling, Timothy M., Freathy, Rachel M., Lango, Hana, Perry, John R. B., Shields, Beverley M., Weedon, Michael N., Hattersley, Andrew T., Hitman, Graham A., Walker, Mark, Elliott, Kate S., Groves, Christopher J., Lindgren, Cecilia M., Rayner, Nigel W., Timpson, Nicholas J., Zeggini, Eleftheria, Newport, Melanie J., Sirugo, Giorgio, Lyons, Emily, Vannberg, Fredrik, Brown, Matthew A., Franklyn, Jayne A., Heward, Joanne M., Simmonds, Matthew J., Hill, Adrian V. 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ISSN 0028-0836 Tue, 16 Aug 2011 09:27:02 +0100 http://sro.sussex.ac.uk/id/eprint/7221/ http://sro.sussex.ac.uk/id/eprint/7221/ Thye, Thorsten, Vannberg, Fredrik O., Wong, Sunny H., Owusu-Dabo, Ellis, Osei, Ivy, Gyapong, John, Sirugo, Giorgio, Sisay-Joof, Fatou, Enimil, Anthony, Chinbuah, Margaret A., Floyd, Sian, Warndorff, David K., Sichali, Lifted, Malema, Simon, Crampin, Amelia C., Ngwira, Bagrey, Teo, Yik Y., Small, Kerrin, Rockett, Kirk, Kwiatkowski, Dominic, Fine, Paul E., Hill, Philip C., Newport, Melanie J., Lienhardt, Christian, Adegbola, Richard A., Corrah, Tumani, Ziegler, Andreas, Morris, Andrew P., Meyer, Christian G., Horstmann, Rolf D. and Hill, Adrian V. S. (2010) Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. Nature Genetics, 42 (9). pp. 739-741. ISSN 1061-4036 Mon, 08 Aug 2011 06:36:59 +0100 http://sro.sussex.ac.uk/id/eprint/7166/ http://sro.sussex.ac.uk/id/eprint/7166/ Brunton, Holly (2011) Investigating the role of higher order chromatin structure and DNA damage complexity on ATM signalling and G2/M checkpoint arrest. Doctoral thesis (DPhil), University of Sussex. Tue, 19 Jul 2011 09:00:35 +0100 http://sro.sussex.ac.uk/id/eprint/6979/ http://sro.sussex.ac.uk/id/eprint/6979/ Warnefors, Anna Maria Linnéa (2011) Evolution of human gene expression. Doctoral thesis (DPhil), University of Sussex. Mon, 20 Jun 2011 07:53:44 +0100 http://sro.sussex.ac.uk/id/eprint/6972/ http://sro.sussex.ac.uk/id/eprint/6972/ Morgan Jones, Molly (2011) Governing the constructs of life: what constitutes ‘good’ governance? Doctoral thesis (DPhil), University of Sussex. Mon, 21 Mar 2011 12:53:55 +0000 http://sro.sussex.ac.uk/id/eprint/6332/ http://sro.sussex.ac.uk/id/eprint/6332/ Chambers, Helen (2011) Investigating the effects of repair of DNA single-strand breaks on chromatin structure. Doctoral thesis (DPhil), University of Sussex. http://sro.sussex.ac.uk/id/eprint/2549/ http://sro.sussex.ac.uk/id/eprint/2549/ Boyd, Lara K, Mercer, Brenda, Thompson, Darren, Main, Ewan and Watts, Felicity W (2010) Characterisation of the SUMO-like domains of Schizosaccharomyces pombe Rad60. PLoS ONE, 5 (9). pp. 1-11. ISSN 1932-6203 http://sro.sussex.ac.uk/id/eprint/2555/ http://sro.sussex.ac.uk/id/eprint/2555/ Rulten, Stuart L, Fisher, Anna E O, Robert, Isabelle, Zuma, Maria C, Rouleau, Michele, Ju, Limei, Poirier, Guy, Reina-San-Martin, Bernardo and Caldecott, Keith W (2011) PARP-3 and APLF function together to accelerate nonhomologous end joining. Molecular Cell, 41 (1). pp. 33-45. ISSN 1097-2765 http://sro.sussex.ac.uk/id/eprint/2522/ http://sro.sussex.ac.uk/id/eprint/2522/ Hirota, Kouji, Sonoda, Eiichiro, Kawamoto, Takuo, Motegi, Akira, Masutani, Chikahide, Hanaoka, Fumio, Szüts, Dávid, Iwai, Shigenori, Sale, Julian E, Lehmann, Alan and Takeda, Shunichi (2010) Simultaneous disruption of two DNA polymerases, Polη and Polζ, in Avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesions. PLoS Genetics, 6 (10). ISSN 1553-7390 http://sro.sussex.ac.uk/id/eprint/2493/ http://sro.sussex.ac.uk/id/eprint/2493/ Grima, Dominic P, Sullivan, Melanie, Zabolotskaya, Maria V, Browne, Cathy, Seago, Julian, Wan, Kay Chong, Okada, Yoshio and Newbury, Sarah F (2008) The 5'-3' exoribonuclease pacman is required for epithelial sheet sealing in Drosophila and genetically interacts with the phosphatase puckered. Biology of the Cell, 100 (12). pp. 687-701. ISSN 0248-4900 http://sro.sussex.ac.uk/id/eprint/2448/ http://sro.sussex.ac.uk/id/eprint/2448/ Laugel, V, Dalloz, C, Durand, M, Sauvanaud, F, Kristensen, U, Vincent, M C, Pasquier, L, Odent, S, Cormier-Daire, V, Gener, B, Tobias, E S, Tolmie, J L, Martin-Coignard, D, Drouin-Garraud, V, Heron, D, Journel, H, Raffo, E, Vigneron, J, Lyonnet, S, Murday, V, Gubser-Mercati, D, Funalot, B, Sanchez del Pozo, J, Muñoz, E, Gennery, A R, Salih, M, Noruzinia, M, Prescott, K, Ramos, L, Stark, Z, Fieggen, K, Chabrol, B, Sarda, P, Edery, P, Bloch-Zupan, A, Fawcett, H, Pham, D, Egly, J M, Lehmann, A R, Sarasin, A and Dollfus, H (2010) Mutation update for the CSB/ERCC6 and CSA/ERCC8 genes involved in Cockayne syndrome. Human Mutation, 31 (2). pp. 113-126. ISSN 1059-7794 http://sro.sussex.ac.uk/id/eprint/2450/ http://sro.sussex.ac.uk/id/eprint/2450/ Mari, Pierre-Olivier, Verbiest, Vincent, Sabbioneda, Simone, Gourdin, Audrey M, Wijgers, Nils, Dinant, Christoffel, Lehmann, Alan R, Vermeulen, Wim and Giglia-Mari, Guiseppina (2010) Influence of the live cell DNA marker DRAQ5 on chromatin-associated processes. DNA Repair, 9 (7). pp. 848-855. ISSN 1568-7864 http://sro.sussex.ac.uk/id/eprint/2451/ http://sro.sussex.ac.uk/id/eprint/2451/ Coulon, Stéphane, Ramasubramanyan, Sharada, Alies, Carole, Philippin, Gaëlle, Lehmann, Alan and Fuchs, Robert P (2010) Rad8Rad5/Mms2–Ubc13 ubiquitin ligase complex controls translesion synthesis in fission yeast. EMBO Journal, 29 (12). pp. 2048-2058. ISSN 0261-4189 http://sro.sussex.ac.uk/id/eprint/2425/ http://sro.sussex.ac.uk/id/eprint/2425/ Abbaszadeh, Fatemah, Clingen, Peter H., Arlett, Colin F., Plowman, P.N, Bourton, E.C, Themis, M., Makarov, E.M., Newbold, R.F, Green, M H and Parris, C.N. (2010) A novel splice variant of the DNA-PKcs gene is associated with clinical and cellular radiosensivity in a patient with xeroderma pigmentosum. Journal of Medical Genetics, 47 (3). pp. 176-181. ISSN 00222593 http://sro.sussex.ac.uk/id/eprint/2427/ http://sro.sussex.ac.uk/id/eprint/2427/ Shore, David and Bianchi, Alessandro (2009) Telomere length regulation: coupling DNA end processing to feedback regulation of telomerase. EMBO Journal, 28 (16). pp. 2309-2322. ISSN 0261-4189 http://sro.sussex.ac.uk/id/eprint/2428/ http://sro.sussex.ac.uk/id/eprint/2428/ Jordan, Philip, Copsey, Alice, Newnham, Louise, Kolar, Elizabeth, Lichten, Michael and Hoffmann, Eva (2009) Ipl1/Aurora B kinase coordinates synaptonemal complex disassembly with cell cycle progression and crossover formation in budding yeast meiosis. Genes & Development, 23 (18). pp. 2237-2251. ISSN 0890-9369 http://sro.sussex.ac.uk/id/eprint/2430/ http://sro.sussex.ac.uk/id/eprint/2430/ Tapia-Alveal, Claudia, Outwin, Emily A, Trempolec, Natalia, Dziadkowiec, Dorota, Murray, Johanne M and O'Connell, Matthew J (2010) SMC complexes and topoisomerase II work together so that sister chromatids can work apart. Cell Cycle, 9 (11). 2065 -2070. ISSN 1538-4101 http://sro.sussex.ac.uk/id/eprint/2264/ http://sro.sussex.ac.uk/id/eprint/2264/ Jeggo, Penny (2009) Mechanisms conferring sensitivity to low dose radiation exposure and consideration of potentially sensitivie individuals. In: Late health effects of ionizing radiation: bridging the experimental and epidemiological divide, 4-6 May 2009, Georgetown University, Washington D.C.. http://sro.sussex.ac.uk/id/eprint/2266/ http://sro.sussex.ac.uk/id/eprint/2266/ Covo, Shay, de Villartay, Jean-Pierre, Jeggo, Penny A and Livneh, Zvi (2009) Translesion DNA synthesis-assisted non-homologous end-joining of complex double-strand breaks prevents loss of DNA sequences in mammalian cells. Nucleic Acids Research, 37 (20). pp. 6737-6745. ISSN 0305-1048 http://sro.sussex.ac.uk/id/eprint/2267/ http://sro.sussex.ac.uk/id/eprint/2267/ Nijnik, Anastasia, Dawson, Sara, Woodbine, Lisa, Visetnoi, Supawan, Bennett, Sophia, Jones, Margaret, Turner, Gareth D, Jeggo, Penelope A, Goodnow, Christopher C and Cornall, Richard J (2009) Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome. Journal of Clinical Investigation, 119 (6). pp. 1696-1705. ISSN 00219738 http://sro.sussex.ac.uk/id/eprint/2260/ http://sro.sussex.ac.uk/id/eprint/2260/ Goodarzi, Aaron A, Noon, Angela T and Jeggo, Penny A (2009) The impact of heterochromatin on DSB repair. Biochemical Society Transactions, 37 (3). pp. 569-576. ISSN 03005127 http://sro.sussex.ac.uk/id/eprint/2261/ http://sro.sussex.ac.uk/id/eprint/2261/ Riballo, Enriqueta, Woodbine, Lisa, Stiff, Thomas, Walker, Sarah A., Goodarzi, Aaron A. and Jeggo, Penny A. (2009) XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation. Nucleic Acids Research, 37 (2). pp. 482-492. ISSN 0305-1048 http://sro.sussex.ac.uk/id/eprint/2263/ http://sro.sussex.ac.uk/id/eprint/2263/ Jeggo, Peggy A. (2009) Risks from low dose/dose rate radiation: what an understanding of DNA damage response mechanisms can tell us. Health Physics, 97 (5). pp. 416-425. ISSN 0017-9078 http://sro.sussex.ac.uk/id/eprint/2255/ http://sro.sussex.ac.uk/id/eprint/2255/ Shore, David and Bianchi, Alessandro (2009) Telomere length regulation: coupling DNA end processing to feedback regulation of telomerase. EMBO Journal, 28 (16). pp. 2309-2322. ISSN 0261-4189 http://sro.sussex.ac.uk/id/eprint/2222/ http://sro.sussex.ac.uk/id/eprint/2222/ Wright, A. J., Takeichi, C., Whitwell, S. C. L, Hankins, M. and Marteau, T. M. (2007) The impact of genetic testing for Crohn's disease, risk magnitude and graphical format on motivation to stop smoking: an experimental analogue study. Clinical Genetics, 73 (4). pp. 306-314. ISSN 0009-9163 http://sro.sussex.ac.uk/id/eprint/2122/ http://sro.sussex.ac.uk/id/eprint/2122/ Connell, Claire M., Colnaghi, Rita and Wheatley, Sally P. (2008) Nuclear survivin has reduced stability and is not cytoprotective. Journal of Biological Chemistry, 238 (6). pp. 3289-3296. ISSN 0021-9258 http://sro.sussex.ac.uk/id/eprint/2127/ http://sro.sussex.ac.uk/id/eprint/2127/ Hishida, T, Kubota, Y, Carr, Antony M and Iwasaki, H (2009) RAD6-RAD18-RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light. Nature, 457 (7229). pp. 612-615. ISSN 0028-0836 http://sro.sussex.ac.uk/id/eprint/2130/ http://sro.sussex.ac.uk/id/eprint/2130/ Dziadkowiec, Dorota, Petters, Edyta, Dyjankiewicz, Agnieszka, Karpinski, Pawel, Garcia, Valerie, Watson, Adam T. and Carr, Antony M. (2009) The role of novel genes rrp1(+) and rrp2(+) in the repair of DNA damage in Schizosaccharomycespombe. DNA Repair, 8 (5). pp. 627-636. ISSN 1568-7864 http://sro.sussex.ac.uk/id/eprint/2110/ http://sro.sussex.ac.uk/id/eprint/2110/ Lehmann, Alan R. (2008) XPD structure reveals its secrets. DNA Repair, 7 (11). pp. 1912-1915. ISSN 1568-7864 http://sro.sussex.ac.uk/id/eprint/2081/ http://sro.sussex.ac.uk/id/eprint/2081/ Newport, Melanie J, Abdelhaq, Sonia, Abulezz, Emal, Adeyemo, Adebowale, Davey, Gail, Gad, Yehia, Hennig, Branwen, Marshall, Patricia A, Mohamed, Amal M, Royal, Charmaine D, Soodyall, Himla and Rotimi, Charles N (2008) Genomics research in Africa: implications for disease diagnosis, treatment and drug development: proceedings of the 5th annual meeting of the African Society of Human Genetics. In: 5th Annual Meeting of the African Society of Human Genetics, 3- 5 November 2007, Cairo, Egypt.