http://sro.sussex.ac.uk/ http://sro.sussex.ac.uk/images/sitelogo.png http://sro.sussex.ac.uk/ Fri, 24 Nov 2023 02:52:18 +0000 Fri, 24 Nov 2023 02:52:18 +0000 en Tue, 13 Sep 2022 12:19:15 +0100 http://sro.sussex.ac.uk/id/eprint/107910/ http://sro.sussex.ac.uk/id/eprint/107910/ Campillo-Funollet, Eduard, Van Yperen, James, Allman, Phil, Bell, Michael, Beresford, Warren, Clay, Jacqueline, Evans, Graham, Dorey, Matthew, Gilchrist, Kate, Memon, Anjum, Pannu, Gurprit, Walkley, Ryan, Watson, Mark and Madzvamuse, Anotida (2021) Predicting and forecasting the impact of local resurgence and outbreaks of COVID-19: use of SEIR-D quantitative epidemiological modelling for healthcare demand and capacity. International Journal of Epidemiology, 50 (4). pp. 1103-1113. ISSN 1464-3685 Wed, 20 Apr 2022 11:37:23 +0100 http://sro.sussex.ac.uk/id/eprint/105370/ http://sro.sussex.ac.uk/id/eprint/105370/ Shi, Kejing, Aviles-Espinosa, Rodrigo, Rendon-Morales, Elizabeth, Woodbine, Lisa, Salvage, Jonathan P, Maniruzzaman, Mohammed and Nokhodchi, Ali (2021) Magnetic field triggerable macroporous PDMS sponge loaded with an anticancer drug, 5-fluorouracil. ACS Biomaterials Science and Engineering, 7 (1). pp. 180-195. ISSN 2373-9878 Tue, 25 Jan 2022 13:56:47 +0000 http://sro.sussex.ac.uk/id/eprint/103898/ http://sro.sussex.ac.uk/id/eprint/103898/ Wells, Sophie (2021) Investigating the role of the KU-binding motif in DNA repair. Doctoral thesis (PhD), University of Sussex. Tue, 18 Jan 2022 13:09:10 +0000 http://sro.sussex.ac.uk/id/eprint/103896/ http://sro.sussex.ac.uk/id/eprint/103896/ Russo, Lilian Cristina, Tomasin, Rebeka, Matos, Isaac Araújo, Manucci, Antonio Carlos, Sowa, Sven T, Dale, Katie, Caldecott, Keith W, Lehtiö, Lari, Schechtman, Deborah, Meotti, Flavia C, Bruni-Cardoso, Alexandre and Hoch, Nicolas Carlos (2021) The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling. Journal of Biological Chemistry, 297 (3). a101041 1-14. ISSN 0021-9258 Mon, 17 Jan 2022 13:22:27 +0000 http://sro.sussex.ac.uk/id/eprint/103877/ http://sro.sussex.ac.uk/id/eprint/103877/ Botta, Elena, Theil, Arjan F, Raams, Anja, Caligiuri, Giuseppina, Giachetti, Sarah, Bione, Silvia, Accadia, Maria, Lombardi, Anita, Smith, Desiree E C, Mendes, Marisa I, Swagemakers, Sigrid M A, Van Der Spek, Peter J, Salomons, Gajja S, Hoeijmakers, Jan H J, Yesodharan, Dhanya, Nampoothiri, Sheela, Ogi, Tomoo, Lehmann, Alan R, Orioli, Donata and Vermeulen, Wim (2021) Protein instability associated with AARS1 and MARS1 mutations causes trichothiodystrophy. Human Molecular Genetics, 30 (18). pp. 1711-1720. ISSN 0964-6906 Fri, 14 Jan 2022 15:08:53 +0000 http://sro.sussex.ac.uk/id/eprint/103834/ http://sro.sussex.ac.uk/id/eprint/103834/ Pascual-Garciá, Alberto, Klein, Jordan D, Villers, Jennifer, Campillo-Funollet, Eduard and Sarkis, Chamsy (2021) Empowering the crowd: feasible strategies for epidemic management in high-density informal settlements. The case of COVID-19 in Northwest Syria. BMJ Global Health, 6 (8). a004656 1-14. ISSN 2059-7908 Thu, 16 Dec 2021 08:21:32 +0000 http://sro.sussex.ac.uk/id/eprint/103390/ http://sro.sussex.ac.uk/id/eprint/103390/ Bailey, Laura J, Teague, Rebecca, Kolesar, Peter, Bainbridge, Lewis J, Lindsay, Howard D and Doherty, Aidan J (2021) PLK1 regulates the PrimPol damage tolerance pathway during the cell cycle. Science Advances, 7 (49). pp. 1-15. ISSN 2375-2548 Fri, 26 Nov 2021 08:32:22 +0000 http://sro.sussex.ac.uk/id/eprint/103092/ http://sro.sussex.ac.uk/id/eprint/103092/ Adamowicz, Marek, Hailstone, Richard, Demin, Annie A, Komulainen, Emilia, Hanzlikova, Hana, Brazina, Jan, Gautam, Amit, Wells, Sophie E and Caldecott, Keith W (2021) XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair. Nature Cell Biology. ISSN 1465-7392 Thu, 28 Oct 2021 08:43:21 +0100 http://sro.sussex.ac.uk/id/eprint/102439/ http://sro.sussex.ac.uk/id/eprint/102439/ Zach, Robert (2021) Employing polymerase usage sequencing to better understand fundamental aspects of eukaryotic replication. Doctoral thesis (PhD), University of Sussex. Tue, 12 Oct 2021 07:19:34 +0100 http://sro.sussex.ac.uk/id/eprint/102253/ http://sro.sussex.ac.uk/id/eprint/102253/ Day, Matthew, Oliver, Antony W and Pearl, Laurence H (2021) Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1. DNA Repair, 108. a103232 1-11. ISSN 1568-7864 Tue, 12 Oct 2021 07:08:17 +0100 http://sro.sussex.ac.uk/id/eprint/102254/ http://sro.sussex.ac.uk/id/eprint/102254/ Prabhakar, Apurva T, James, Claire D, Das, Dipon, Otoa, Raymonde, Day, Matthew, Burgner, John, Fontan, Christian T, Wang, Xu, Glass, Sarah H, Wieland, Andreas, Donaldson, Mary M, Bristol, Molly L, Li, Renfeng, Oliver, Antony W, Pearl, Laurence H, Smith, Brian O and Morgana, Iain M (2021) CK2 phosphorylation of human papillomavirus 16 E2 on serine 23 promotes interaction with TopBP1 and Is critical for E2 interaction with mitotic chromatin and the viral life cycle. mBio, 12 (5). pp. 1-23. ISSN 2150-7511 Mon, 11 Oct 2021 09:35:36 +0100 http://sro.sussex.ac.uk/id/eprint/102209/ http://sro.sussex.ac.uk/id/eprint/102209/ Johnson, Dominic, Crawford, Margaret, Cooper, Tim, Claeys Bouuaert, Corentin, Keeney, Scott, Llorente, Bertrand, Garcia, Valerie and Neale, Matthew J (2021) Concerted cutting by Spo11 illuminates meiotic DNA break mechanics. Nature, 594. pp. 572-576. ISSN 0028-0836 Mon, 11 Oct 2021 09:26:27 +0100 http://sro.sussex.ac.uk/id/eprint/102210/ http://sro.sussex.ac.uk/id/eprint/102210/ Bergero, Roberta, Ellis, Peter, Haerty, Wilfried, Larcombe, Lee, Macaulay, Iain, Mehta, Tarang, Mogensen, Mette, Murray, David, Nash, Will, Neale, Matthew J, O'Connor, Rebecca, Ottolini, Christian, Peel, Ned, Ramsey, Luke, Skinner, Ben and others, (2021) Meiosis and beyond – understanding the mechanistic and evolutionary processes shaping the germline genome. Biological Reviews, 96 (3). pp. 822-841. ISSN 1464-7931 Mon, 27 Sep 2021 16:33:08 +0100 http://sro.sussex.ac.uk/id/eprint/101948/ http://sro.sussex.ac.uk/id/eprint/101948/ Zach, Robert and Carr, Antony M (2021) Increased expression of Polδ does not alter the canonical replication program in vivo. Wellcome Open Research, 6. a44 1-18. ISSN 2398-502X Mon, 27 Sep 2021 15:51:52 +0100 http://sro.sussex.ac.uk/id/eprint/101947/ http://sro.sussex.ac.uk/id/eprint/101947/ Demin, Annie A, Hirota, Kouji, Tsuda, Masataka, Adamowicz, Marek, Hailstone, Richard, Brazina, Jan, Gittens, William, Kalasova, Ilona, Shao, Zhengping, Zha, Shan, Sasanuma, Hiroyuki, Hanzlikova, Hana, Takeda, Shunichi and Caldecott, Keith W (2021) XRCC1 prevents toxic PARP1 trapping during DNA base excision repair. Molecular Cell, 81 (14). 3018-3030.e5. ISSN 1097-2765 Fri, 24 Sep 2021 15:27:48 +0100 http://sro.sussex.ac.uk/id/eprint/101901/ http://sro.sussex.ac.uk/id/eprint/101901/ Anbalagan, Selvakumar, Ström, Cecilia, Downs, Jessica A, Jeggo, Penny A, McBay, David, Wilkins, Anna, Rothkamm, Kai, Harrington, Kevin J, Yarnold, John R and Somaiah, Navita (2021) TP53 modulates radiotherapy fraction size sensitivity in normal and malignant cells. Scientific Reports, 11 (1). a7119 1-11. ISSN 2045-2322 Fri, 24 Sep 2021 11:42:12 +0100 http://sro.sussex.ac.uk/id/eprint/101892/ http://sro.sussex.ac.uk/id/eprint/101892/ Pal, Mohinder, Muñoz-Hernandez, Hugo, Bjorklund, Dennis, Zhou, Lihong, Degliesposti, Gianluca, Skehel, J Mark, Hesketh, Emma L, Thompson, Rebecca F, Pearl, Laurence H, Llorca, Oscar and Prodromou, Chrisostomos (2021) Structure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone. Cell Reports, 36 (1). a109317 e1-e6. ISSN 2211-1247 Fri, 24 Sep 2021 11:22:42 +0100 http://sro.sussex.ac.uk/id/eprint/101890/ http://sro.sussex.ac.uk/id/eprint/101890/ Day, Matthew, Parry-Morris, Sarah, Houghton-Gisby, Jack, Oliver, Antony W and Pearl, Laurence H (2021) Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein. Structure, 29 (6). 531-539.e3. ISSN 0969-2126 Fri, 10 Sep 2021 15:05:47 +0100 http://sro.sussex.ac.uk/id/eprint/101631/ http://sro.sussex.ac.uk/id/eprint/101631/ Komulainen, Emilia, Badman, Jack, Rey, Stephanie, Rulten, Stuart, Ju, Limei, Fennell, Kate, Kalasova, Ilona, Ilievova, Kristyna, McKinnon, Peter J, Hanzlikova, Hana, Staras, Kevin and Caldecott, Keith W (2021) Parp1 hyperactivity couples DNA breaks to aberrant neuronal calcium signalling and lethal seizures. EMBO Reports, 22 (5). a51851 1-12. ISSN 1469-221X Fri, 10 Sep 2021 12:56:30 +0100 http://sro.sussex.ac.uk/id/eprint/101627/ http://sro.sussex.ac.uk/id/eprint/101627/ Mocanu, Camelia and Chan, Kok-Lung (2021) Mind the replication gap. Royal Society Open Science, 8 (6). a201932 1-19. ISSN 2054-5703 Fri, 27 Aug 2021 08:22:16 +0100 http://sro.sussex.ac.uk/id/eprint/101342/ http://sro.sussex.ac.uk/id/eprint/101342/ Crncec, Adrijana (2021) A new chemical genetics toolbox to analyse genes essential for the mitotic entry. Doctoral thesis (PhD), University of Sussex. Wed, 25 Aug 2021 07:34:15 +0100 http://sro.sussex.ac.uk/id/eprint/101284/ http://sro.sussex.ac.uk/id/eprint/101284/ Bainbridge, Lewis J, Teague, Rebecca and Doherty, Aidan J (2021) Repriming DNA synthesis: an intrinsic restart pathway that maintains efficient genome replication. Nucleic Acids Research, 49 (9). pp. 4831-4847. ISSN 0305-1048 Wed, 25 Aug 2021 07:13:40 +0100 http://sro.sussex.ac.uk/id/eprint/101283/ http://sro.sussex.ac.uk/id/eprint/101283/ Zabrady, Katerina, Zabrady, Matej, Kolesar, Peter, Li, Arthur W H and Doherty, Aidan J (2021) CRISPR-Associated Primase-Polymerases are implicated in prokaryotic CRISPR-Cas adaptation. Nature Communications, 12 (1). a3690 1-18. ISSN 2041-1723 Mon, 23 Aug 2021 07:15:01 +0100 http://sro.sussex.ac.uk/id/eprint/101256/ http://sro.sussex.ac.uk/id/eprint/101256/ Khayat, Freddy, Cannavo, Elda, Alshmery, Majedh, Foster, William R, Chahwan, Charly, Maddalena, Martino, Smith, Christophe, Oliver, Antony W, Watson, Adam T, Carr, Antony M, Cejka, Petr and Bianchi, Alessandro (2021) Inhibition of MRN activity by a telomere protein motif. Nature Communications, 12 (1). a3856 1-16. ISSN 2041-1723 Thu, 05 Aug 2021 10:09:37 +0100 http://sro.sussex.ac.uk/id/eprint/100956/ http://sro.sussex.ac.uk/id/eprint/100956/ Budden, Alice (2021) Analysis of homologous recombination restarted replication forks in S. pombe. Doctoral thesis (PhD), University of Sussex. Mon, 26 Jul 2021 13:41:39 +0100 http://sro.sussex.ac.uk/id/eprint/95349/ http://sro.sussex.ac.uk/id/eprint/95349/ Campillo-Funollet, Eduard, Van Yperen, James, Allman, Phil, Bell, Michael, Beresford, Warren, Clay, Jacqueline, Dorey, Matthew, Evans, Graham, Gilchrist, Kate, Memon, Anjum, Pannu, Gurprit, Walkley, Ryan, Watson, Mark and Madzvamuse, Anotida (2021) Predicting and forecasting the impact of local outbreaks of COVID-19: use of SEIR-D quantitative epidemiological modelling for healthcare demand and capacity. International Journal of Epidemiology, 50 (4). pp. 1103-1113. ISSN 0300-5771 Mon, 14 Jun 2021 08:13:14 +0100 http://sro.sussex.ac.uk/id/eprint/99761/ http://sro.sussex.ac.uk/id/eprint/99761/ Liu, Yang, Wang, Lu, Xu, Xin, Yuan, Yue, Zhang, Bo, Li, Zeyang, Xie, Yuchen, Yan, Rui, Zheng, Zeqi, Ji, Jianguo, Murray, Johanne M, Carr, Antony M and Kong, Daochun (2021) The intra-S phase checkpoint directly regulates replication elongation to preserve the integrity of stalled replisomes. Proceedings of the National Academy of Sciences (PNAS), 118 (24). a2019183118. ISSN 0027-8424 Thu, 13 May 2021 06:45:02 +0100 http://sro.sussex.ac.uk/id/eprint/99064/ http://sro.sussex.ac.uk/id/eprint/99064/ Wu, Wei, Hill, Sarah E, Nathan, William J, Paiano, Jacob, Callen, Elsa, Wang, Dongpeng, Shinoda, Kenta, van Wietmarschen, Niek, Colón-Mercado, Jennifer M, Zong, Dali, De Pace, Raffaella, Shih, Han-Yu, Coon, Steve, Hanzlikova, Hana, Caldecott, Keith W and others, (2021) Neuronal enhancers are hotspots for DNA single-strand break repair. Nature, 593. pp. 440-444. ISSN 0028-0836 Mon, 10 May 2021 08:50:25 +0100 http://sro.sussex.ac.uk/id/eprint/98924/ http://sro.sussex.ac.uk/id/eprint/98924/ Hudson, Jessica J R and Rass, Ulrich (2021) Dna2 in chromosome stability and cell survival—is it all about replication forks? International Journal of Molecular Sciences, 22 (8). a3984 1-24. ISSN 1661-6596 Wed, 28 Apr 2021 13:31:32 +0100 http://sro.sussex.ac.uk/id/eprint/98731/ http://sro.sussex.ac.uk/id/eprint/98731/ Westhorpe, Rose (2021) Investigating the functions of Tof1/Timeless in Saccharomyces cerevisiae and human cells. Doctoral thesis (PhD), University of Sussex. Mon, 19 Apr 2021 07:53:59 +0100 http://sro.sussex.ac.uk/id/eprint/98475/ http://sro.sussex.ac.uk/id/eprint/98475/ Etheridge, Thomas J, Villahermosa, Desiree, Campillo-Funollet, Eduard, Herbert, Alex David, Irmisch, Anja, Watson, Adam T, Dang, Hung Q, Osborne, Mark A, Oliver, Antony W, Carr, Antony M and Murray, Johanne M (2021) Live-cell single-molecule tracking highlights requirements for stable Smc5/6 chromatin association in vivo. eLife, 10. a68579. ISSN 2050-084X Wed, 14 Apr 2021 07:25:51 +0100 http://sro.sussex.ac.uk/id/eprint/98441/ http://sro.sussex.ac.uk/id/eprint/98441/ Ghodke, Indrajeet, Remisova, Michaela, Furst, Audrey, Kilic, Sinan, Reina-San-Martin, Bernardo, Poetsch, Anna R, Altmeyer, Matthias and Soutoglou, Evi (2021) AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation. Molecular Cell. pp. 1-15. ISSN 1097-2765 Fri, 09 Apr 2021 07:03:54 +0100 http://sro.sussex.ac.uk/id/eprint/98318/ http://sro.sussex.ac.uk/id/eprint/98318/ Hallett, Stephen T, Schellenberger, Pascale, Zhou, Lihong, Beuron, Fabienne, Morris, Ed, Murray, Johanne M and Oliver, Antony W (2021) Nse5/6 is a negative regulator of the ATPase activity of the Smc5/6 complex. Nucleic Acids Research, 49 (8). pp. 4534-4549. ISSN 0305-1048 Fri, 09 Apr 2021 06:53:16 +0100 http://sro.sussex.ac.uk/id/eprint/98319/ http://sro.sussex.ac.uk/id/eprint/98319/ Chen, Xiangrong, Ali, Yusuf I, Fisher, Charlotte E L, Arribas-Bosacoma, Raquel, Rajasekaran, Mohan B, Williams, Gareth, Walker, Sarah, Booth, Jessica R, Hudson, Jessica J R, Roe, S Mark, Pearl, Laurence H, Ward, Simon E, Pearl, Frances M G and Oliver, Antony W (2021) Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein. eLife, 10. a65339 1-32. ISSN 2050-084X Mon, 01 Feb 2021 08:12:52 +0000 http://sro.sussex.ac.uk/id/eprint/96813/ http://sro.sussex.ac.uk/id/eprint/96813/ Harries, Rhiannon W, Brown, Christopher J, Woodbine, Lisa, Amorim Graf, Aline, Large, Matthew J, Clifford, Keiran, Lynch, Peter J, Ogilvie, Sean P, Dalton, Alan B and King, Alice A K (2021) Cell–substrate interactions lead to internalization and localization of layered MoS₂ nanosheets. ACS Applied Nano Materials, 4 (2). pp. 2002-2010. ISSN 2574-0970 Tue, 19 Jan 2021 13:17:11 +0000 http://sro.sussex.ac.uk/id/eprint/96571/ http://sro.sussex.ac.uk/id/eprint/96571/ Naiman, Karel, Campillo-Funollet, Eduard, Watson, Adam T, Budden, Alice, Miyabe, Izumi and Carr, Antony M (2021) Replication dynamics of recombination-dependent replication forks. Nature Communications, 12. a923 1-11. ISSN 2041-1723