Sussex Research Online: No conditions. Results ordered -Date Deposited. http://sro.sussex.ac.uk/ http://sro.sussex.ac.uk/images/sitelogo.png Sussex Research Online: No conditions. Results ordered -Date Deposited. http://sro.sussex.ac.uk/ Thu, 23 Nov 2023 13:02:51 +0000 Thu, 23 Nov 2023 13:02:51 +0000 en Wed, 06 Dec 2017 11:57:19 +0000 Spirooxindoles derivatives as novel inhibitors of the respiratory syncytial virus http://sro.sussex.ac.uk/id/eprint/71864/ http://sro.sussex.ac.uk/id/eprint/71864/ Paradowski, Michael (2017) Spirooxindoles derivatives as novel inhibitors of the respiratory syncytial virus. Doctoral thesis (PhD), University of Sussex. Tue, 05 Dec 2017 09:42:12 +0000 African trypanosomiasis: Synthesis & SAR enabling novel drug discovery of ubiquinol mimics for trypanosome alternative oxidase http://sro.sussex.ac.uk/id/eprint/71807/ http://sro.sussex.ac.uk/id/eprint/71807/ West, Ryan A, O'Doherty, Oran G, Askwith, Trevor, Atack, John, Beswick, Paul, Laverick, Jamie, Paradowski, Michael, Pennicott, Lewis E, Rao, Srinivasa P S, Williams, Gareth and Ward, Simon E (2017) African trypanosomiasis: Synthesis & SAR enabling novel drug discovery of ubiquinol mimics for trypanosome alternative oxidase. European Journal of Medicinal Chemistry, 141. pp. 676-689. ISSN 0223-5234 Tue, 26 Apr 2016 09:20:24 +0100 Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2 http://sro.sussex.ac.uk/id/eprint/60620/ http://sro.sussex.ac.uk/id/eprint/60620/ Hornyak, Peter, Askwith, Trevor, Walker, Sarah, Komulainen, Emilia, Paradowski, Michael, Pennicott, Lewis E, Bartlett, Edward J, Brissett, Nigel C, Raoof, Ali, Watson, Mandy, Jordan, Allan M, Ogilvie, Donald J, Ward, Simon E, Atack, John R, Pearl, Laurence H, Caldecott, Keith W and Oliver, Antony W (2016) Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2. Biochemical Journal, 473 (13). pp. 1869-1879. ISSN 0264-6021 Wed, 23 Oct 2013 09:55:01 +0100 Incorporation by coordination and release of the iron chelator drug deferiprone from zinc-based metal–organic frameworks http://sro.sussex.ac.uk/id/eprint/46792/ http://sro.sussex.ac.uk/id/eprint/46792/ Burrows, Andrew D, Jurcic, Monika, Keenan, Luke L, Lane, Rebecca A, Mahon, Mary F, Warren, Mark R, Nowell, Harriot, Paradowski, Michael and Spencer, John (2013) Incorporation by coordination and release of the iron chelator drug deferiprone from zinc-based metal–organic frameworks. Chemical Communications, 49. pp. 11260-11262. ISSN 1359-7345 Tue, 12 Feb 2013 08:29:17 +0000 Synthesis of the C1-C16 fragment of the ajudazols http://sro.sussex.ac.uk/id/eprint/21378/ http://sro.sussex.ac.uk/id/eprint/21378/ Egan, Ben A, Paradowski, Michael, Thomas, Lynne H and Marquez, Rodolfo (2011) Synthesis of the C1-C16 fragment of the ajudazols. Tetrahedron, 67 (50). pp. 9700-9707. ISSN 0040-4020 Mon, 06 Feb 2012 20:52:29 +0000 A flexible synthesis of C-6 and N-1 analogues of a 4-amino-1,3-dihydroimidazo[4,5-c]pyridin-2-one core http://sro.sussex.ac.uk/id/eprint/28525/ http://sro.sussex.ac.uk/id/eprint/28525/ Paradowski, Michael (2011) A flexible synthesis of C-6 and N-1 analogues of a 4-amino-1,3-dihydroimidazo[4,5-c]pyridin-2-one core. Tetrahedron Letters, 52 (44). pp. 5728-5732. ISSN 00404039 Mon, 06 Feb 2012 20:45:32 +0000 The discovery of a novel prototype small molecule TLR7 agonist for the treatment of hepatitis C virus infection http://sro.sussex.ac.uk/id/eprint/27935/ http://sro.sussex.ac.uk/id/eprint/27935/ Paradowski, Michael (2011) The discovery of a novel prototype small molecule TLR7 agonist for the treatment of hepatitis C virus infection. MedChemComm, 2 (3). pp. 185-189. ISSN 20402503 Mon, 06 Feb 2012 20:29:49 +0000 Development of a Practical Synthesis of Toll-like Receptor Agonist PF-4171455: 4-Amino-1-benzyl-6-trifluoromethyl-1,3-dihydroimidazo [4,5-c] pyridin-2-one http://sro.sussex.ac.uk/id/eprint/26167/ http://sro.sussex.ac.uk/id/eprint/26167/ Paradowski, Michael (2011) Development of a Practical Synthesis of Toll-like Receptor Agonist PF-4171455: 4-Amino-1-benzyl-6-trifluoromethyl-1,3-dihydroimidazo [4,5-c] pyridin-2-one. Organic Process Research and Development, 45 (4). pp. 788-796. ISSN 10836160 Mon, 06 Feb 2012 20:27:31 +0000 Challenges of drug discovery in novel target space. The Discovery and Evaluation of PF-3893787: A Novel Histamine H4 Receptor Antagonist http://sro.sussex.ac.uk/id/eprint/25985/ http://sro.sussex.ac.uk/id/eprint/25985/ Paradowski, Michael (2011) Challenges of drug discovery in novel target space. The Discovery and Evaluation of PF-3893787: A Novel Histamine H4 Receptor Antagonist. Bioorganic and Medicinal Chemistry Letters, 21. pp. 6596-6602. ISSN 0960894X Mon, 06 Feb 2012 20:05:19 +0000 Novel isobenzofuran oxidative rearrangements: Total synthesis of Ajudazol A http://sro.sussex.ac.uk/id/eprint/23962/ http://sro.sussex.ac.uk/id/eprint/23962/ Paradowski, Michael (2010) Novel isobenzofuran oxidative rearrangements: Total synthesis of Ajudazol A. In: 239th ACS National Meeting, San Francisco, CA, United States. Mon, 06 Feb 2012 19:51:53 +0000 Regiocontrolled Rearrangement of Isobenzofurans http://sro.sussex.ac.uk/id/eprint/22619/ http://sro.sussex.ac.uk/id/eprint/22619/ Paradowski, Michael (2011) Regiocontrolled Rearrangement of Isobenzofurans. Organic Letters, 13 (8). pp. 2086-2089. ISSN 15237060 Mon, 06 Feb 2012 19:02:13 +0000 Synthesis of a novel octahydro pyrrolo[3,4-c] pyrrole cyclic amidine via 1,3-dipolar cycloaddition of azomethine ylides http://sro.sussex.ac.uk/id/eprint/19041/ http://sro.sussex.ac.uk/id/eprint/19041/ Paradowski, Michael (2011) Synthesis of a novel octahydro pyrrolo[3,4-c] pyrrole cyclic amidine via 1,3-dipolar cycloaddition of azomethine ylides. Synlett (11). pp. 1543-1546. ISSN 09365214