http://sro.sussex.ac.uk/ http://sro.sussex.ac.uk/images/sitelogo.png http://sro.sussex.ac.uk/ Sun, 26 Nov 2023 08:28:15 +0000 Sun, 26 Nov 2023 08:28:15 +0000 en Fri, 19 May 2023 10:39:15 +0100 http://sro.sussex.ac.uk/id/eprint/112419/ http://sro.sussex.ac.uk/id/eprint/112419/ Oberoi, Jasmeen, Aran Guiu, Xavi, Outwin, Emily A, Schellenberger, Pascale, Roumeliotis, Theodoros I, Choudhary, Jyoti S and Pearl, Laurence H (2022) HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation. Nature Communications, 13. a7343 1-13. ISSN 2041-1723 Tue, 21 Jun 2022 12:26:50 +0100 http://sro.sussex.ac.uk/id/eprint/106483/ http://sro.sussex.ac.uk/id/eprint/106483/ Meyer, Philippe, Prodromou, Chrisostomos, Liao, Chunyan, Hu, Bin, Roe, S Mark, Vaughan, Cara K, Vlasic, Ignacija, Panaretou, Barry, Piper, Peter W and Pearl, Laurence H (2004) Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery. EMBO Journal, 23. pp. 511-519. ISSN 0261-4189 Tue, 21 Jun 2022 11:24:13 +0100 http://sro.sussex.ac.uk/id/eprint/106482/ http://sro.sussex.ac.uk/id/eprint/106482/ Sharp, Swee Y, Boxall, Kathy, Rowlands, Martin, Prodromou, Chrisostomos, Roe, S Mark, Maloney, Alison, Powers, Marissa, Clarke, Paul A, Box, Gary, Sanderson, Sharon, Patterson, Lisa, Matthews, Thomas P, Cheung, Kwai-Ming J, Ball, Karen, Pearl, Laurence and others, (2019) Correction: In vitro Biological Characterization of a Novel, Synthetic Diaryl Pyrazole Resorcinol Class of Heat Shock Protein 90 Inhibitors. Cancer Research, 79 (1). p. 287. ISSN 0008-5472 Tue, 21 Jun 2022 11:20:52 +0100 http://sro.sussex.ac.uk/id/eprint/106481/ http://sro.sussex.ac.uk/id/eprint/106481/ Polier, Sigrun, Samant, Rahul S, Clarke, Paul A, Workman, Paul, Prodromou, Chrisostomos and Pearl, Laurence H (2013) Erratum: ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system (Nature Chemical Biology (2013) 9 (307-312)). Nature Chemical Biology, 9. p. 406. ISSN 1552-4450 Tue, 21 Jun 2022 11:14:00 +0100 http://sro.sussex.ac.uk/id/eprint/106478/ http://sro.sussex.ac.uk/id/eprint/106478/ Martino, Fabrizio, Pal, Mohinder, Muñoz-Hernández, Hugo, Rodríguez, Carlos F, Núñez-Ramírez, Rafael, Gil-Carton, David, Degliesposti, Gianluca, Skehel, J Mark, Roe, S Mark, Prodromou, Chrisostomos, Pearl, Laurence H and Llorca, Oscar (2018) Erratum to: RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex. Nature Communications, 9. p. 3063. ISSN 2041-1723 Tue, 21 Jun 2022 11:04:17 +0100 http://sro.sussex.ac.uk/id/eprint/106477/ http://sro.sussex.ac.uk/id/eprint/106477/ Pal, M, Morgan, M, Phelps, S, Roe, M, Parry-Morris, S, Downs, J, Polier, S, Pearl, L and Prodromou, C (2014) Structural basis for the interaction of HSP90 with R2TP and TTT complexes. In: XXIII IUCr Congress, August 2014, Montreal, Canada. Tue, 12 Oct 2021 07:19:34 +0100 http://sro.sussex.ac.uk/id/eprint/102253/ http://sro.sussex.ac.uk/id/eprint/102253/ Day, Matthew, Oliver, Antony W and Pearl, Laurence H (2021) Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1. DNA Repair, 108. a103232 1-11. ISSN 1568-7864 Tue, 12 Oct 2021 07:08:17 +0100 http://sro.sussex.ac.uk/id/eprint/102254/ http://sro.sussex.ac.uk/id/eprint/102254/ Prabhakar, Apurva T, James, Claire D, Das, Dipon, Otoa, Raymonde, Day, Matthew, Burgner, John, Fontan, Christian T, Wang, Xu, Glass, Sarah H, Wieland, Andreas, Donaldson, Mary M, Bristol, Molly L, Li, Renfeng, Oliver, Antony W, Pearl, Laurence H, Smith, Brian O and Morgana, Iain M (2021) CK2 phosphorylation of human papillomavirus 16 E2 on serine 23 promotes interaction with TopBP1 and Is critical for E2 interaction with mitotic chromatin and the viral life cycle. mBio, 12 (5). pp. 1-23. ISSN 2150-7511 Fri, 24 Sep 2021 11:42:12 +0100 http://sro.sussex.ac.uk/id/eprint/101892/ http://sro.sussex.ac.uk/id/eprint/101892/ Pal, Mohinder, Muñoz-Hernandez, Hugo, Bjorklund, Dennis, Zhou, Lihong, Degliesposti, Gianluca, Skehel, J Mark, Hesketh, Emma L, Thompson, Rebecca F, Pearl, Laurence H, Llorca, Oscar and Prodromou, Chrisostomos (2021) Structure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone. Cell Reports, 36 (1). a109317 e1-e6. ISSN 2211-1247 Fri, 24 Sep 2021 11:22:42 +0100 http://sro.sussex.ac.uk/id/eprint/101890/ http://sro.sussex.ac.uk/id/eprint/101890/ Day, Matthew, Parry-Morris, Sarah, Houghton-Gisby, Jack, Oliver, Antony W and Pearl, Laurence H (2021) Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein. Structure, 29 (6). 531-539.e3. ISSN 0969-2126 Fri, 09 Apr 2021 06:53:16 +0100 http://sro.sussex.ac.uk/id/eprint/98319/ http://sro.sussex.ac.uk/id/eprint/98319/ Chen, Xiangrong, Ali, Yusuf I, Fisher, Charlotte E L, Arribas-Bosacoma, Raquel, Rajasekaran, Mohan B, Williams, Gareth, Walker, Sarah, Booth, Jessica R, Hudson, Jessica J R, Roe, S Mark, Pearl, Laurence H, Ward, Simon E, Pearl, Frances M G and Oliver, Antony W (2021) Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein. eLife, 10. a65339 1-32. ISSN 2050-084X Mon, 16 Nov 2020 09:37:47 +0000 http://sro.sussex.ac.uk/id/eprint/95103/ http://sro.sussex.ac.uk/id/eprint/95103/ Ditsiou, Angeliki, Cilibrasi, Chiara, Simigdala, Nikiana, Harris, Leanne, Vella, Viviana, Gagliano, Teresa, Iachini, Maria Chiara, Simon, Thomas, Zhou, Lihong, Hassell-Hart, Storm, Pearl, Laurence H, Roe, S Mark, Spencer, John, Prodromou, Chrisostomos, Giamas, Georgios and others, (2020) The structure-function relationship of oncogenic LMTK3. Science Advances, 6 (46). pp. 1-19. ISSN 2375-2548 Tue, 11 Jun 2019 07:41:04 +0100 http://sro.sussex.ac.uk/id/eprint/84221/ http://sro.sussex.ac.uk/id/eprint/84221/ Bigot, Nicolas, Day, Matthew, Baldock, Robbie A, Watts, Felicity Z, Oliver, Antony W and Pearl, Laurence H (2019) Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint. eLIfe, 8. a44353 1-28. ISSN 2050-084X Wed, 08 May 2019 10:27:55 +0100 http://sro.sussex.ac.uk/id/eprint/83597/ http://sro.sussex.ac.uk/id/eprint/83597/ Muñoz-Hernández, Hugo, Pal, Mohinder, Rodríguez, Carlos F, Fernandez-Leiro, Rafael, Prodromou, Chrisostomos, Pearl, Laurence H and Llorca, Oscar (2019) Structural mechanism for regulation of the AAA-ATPases RUVBL1-RUVBL2 in the R2TP co-chaperone revealed by cryo-EM. Science Advances, 5 (5). eaaw1616 1-11. ISSN 2375-2548 Tue, 09 Apr 2019 07:44:47 +0100 http://sro.sussex.ac.uk/id/eprint/83083/ http://sro.sussex.ac.uk/id/eprint/83083/ Leimbacher, Pia-Amata, Jones, Samuel E, Shorrocks, Ann-Marie K, de Marco Zompit, Mara, Day, Matthew, Blaauwendraad, Jordy, Bundschuh, Diana, Bonham, Sarah, Fischer, Roman, Fink, Daniel, Kessler, Benedikt M, Oliver, Antony W, Pearl, Laurence H, Blackford, Andrew N and Stucki, Manuel (2019) MDC1 interacts with TOPBP1 to maintain chromosomal stability during mitosis. Molecular Cell. ISSN 1097-2765 Tue, 05 Feb 2019 14:02:10 +0000 http://sro.sussex.ac.uk/id/eprint/81411/ http://sro.sussex.ac.uk/id/eprint/81411/ Polo, Luis M, Xu, Yingqi, Hornyak, Peter, Garces, Fernando, Zeng, Zhihong, Hailstone, Richard, Matthews, Steve J, Caldecott, Keith W, Oliver, Antony W and Pearl, Laurence H (2019) Efficient single-strand break repair requires binding to both poly(ADP-ribose) and DNA by the central BRCT domain of XRCC1. Cell Reports, 26 (3). 573-581.e5. ISSN 2211-1247 Fri, 14 Dec 2018 15:27:57 +0000 http://sro.sussex.ac.uk/id/eprint/80799/ http://sro.sussex.ac.uk/id/eprint/80799/ Muñoz-Hernández, Hugo, Pal, Mohinder, Rodríguez, Carlos F, Prodromou, Chrisostomos, Pearl, Laurence H and Lllorca, Oscar (2018) Advances on the structure of the R2TP/Prefoldin-like complex. In: Djouder, Nabil (ed.) PrefoldinsL the new chaperones. Advances in Experimental Medicine and Biology, 1106 . Springer, Cham, pp. 73-83. ISBN 9783030007362 Tue, 09 Oct 2018 14:18:56 +0100 http://sro.sussex.ac.uk/id/eprint/79292/ http://sro.sussex.ac.uk/id/eprint/79292/ Day, Matthew, Rappas, Mathieu, Ptasinska, Katie, Boos, Dominik, Oliver, Antony W and Pearl, Laurence H (2018) BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands. eLife, 7 (e39979). pp. 1-18. ISSN 2050-084X Mon, 04 Dec 2017 08:25:26 +0000 http://sro.sussex.ac.uk/id/eprint/71748/ http://sro.sussex.ac.uk/id/eprint/71748/ Prodromou, Chrisostomos and Pearl, Laurence (2013) Structural basis of Hsp90 function. In: Machajewski, Timothy D, Gao, Zhenhai and Rotella, David (eds.) Inhibitors of molecular chaperones as therapeutic agents. RSC drug discovery; No. 37 . RSC Publishing, Cambridge, UK, pp. 37-64. ISBN 9781849736664 Mon, 06 Nov 2017 09:49:42 +0000 http://sro.sussex.ac.uk/id/eprint/70934/ http://sro.sussex.ac.uk/id/eprint/70934/ Hallett, Stephen T, Pastok, Martyna W, Morgan, R Marc L, Wittner, Anita, Blundell, Katie L I M, Felletar, Ildiko, Wedge, Stephen R, Prodromou, Chrisostomos, Noble, Martin E M, Pearl, Laurence H and Endicott, Jane A (2017) Differential regulation of G1 CDK complexes by the Hsp90-Cdc37 chaperone system. Cell Reports, 21 (5). pp. 1386-1398. ISSN 2211-1247 Fri, 28 Jul 2017 08:30:51 +0100 http://sro.sussex.ac.uk/id/eprint/69508/ http://sro.sussex.ac.uk/id/eprint/69508/ Rivera-Calzada, Angel, Pal, Mohinder, Muñoz-Hernández, Hugo, Luque-Ortega, Juan R, Gil-Carton, David, Degliesposti, Gianluca, Skehel, J. Mark, Prodromou, Chrisostomos, Pearl, Laurence H and llorca, Oscar (2017) The structure of the R2TP complex defines a platform for recruiting diverse client proteins to the HSP90 molecular chaperone system. Structure, 25 (7). pp. 1145-1152. ISSN 0969-2126 Thu, 22 Jun 2017 11:24:45 +0100 http://sro.sussex.ac.uk/id/eprint/68775/ http://sro.sussex.ac.uk/id/eprint/68775/ Li, Zhaobo, Zhou, Lihong, Prodromou, Chrisostomos, Savic, Velibor and Pearl, Laurence H (2017) HECTD3 mediates an HSP90-dependent degradation pathway for protein kinase clients. Cell Reports, 19 (12). pp. 2515-2528. ISSN 2211-1247 Thu, 04 May 2017 14:20:23 +0100 http://sro.sussex.ac.uk/id/eprint/67665/ http://sro.sussex.ac.uk/id/eprint/67665/ Schulze, Andrea, Beliu, Gerti, Helmerich, Dominic A, Schubert, Jonathan, Pearl, Laurence H, Prodromou, Chrisostomos and Neuweiler, Hannes (2016) Cooperation of local motions in the Hsp90 molecular chaperone ATPase mechanism. Nature Chemical Biology, 12 (8). pp. 628-635. ISSN 1552-4450 Fri, 10 Mar 2017 14:53:23 +0000 http://sro.sussex.ac.uk/id/eprint/67055/ http://sro.sussex.ac.uk/id/eprint/67055/ Blundell, Katie L I M, Pal, Mohinder, Roe, S Mark, Pearl, Laurence H and Prodromou, Chrisostomos (2017) The structure of FKBP38 in complex with the MEEVD tetratricopeptide binding-motif of Hsp90. PLoS ONE, 12 (3). e0173543. ISSN 1932-6203 Tue, 31 Jan 2017 15:39:16 +0000 http://sro.sussex.ac.uk/id/eprint/66519/ http://sro.sussex.ac.uk/id/eprint/66519/ Alt, Aaron, Dang, Hung Q, Wells, Owen S, Polo, Luis M, Smith, Matt A, McGregor, Grant A, Welte, Thomas, Lehmann, Alan R, Pearl, Laurence H, Murray, Johanne M and Oliver, Antony W (2017) Specialized interfaces of Smc5/6 control hinge stability and DNA association. Nature Communications, 8. a14011 1-14. ISSN 2041-1723 Fri, 26 Aug 2016 16:03:48 +0100 http://sro.sussex.ac.uk/id/eprint/63037/ http://sro.sussex.ac.uk/id/eprint/63037/ Ocasio, Cory A, Rajasekaran, Mohan B, Walker, Sarah, Le Grand, Darren, Spencer, John, Pearl, Frances M G, Ward, Simon E, Savic, Velibor, Pearl, Laurence H, Hochegger, Helfrid and Oliver, Antony W (2016) A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct. Oncotarget, 7 (44). 71182 -71197. ISSN 1949-2553 Fri, 26 Aug 2016 15:25:33 +0100 http://sro.sussex.ac.uk/id/eprint/63036/ http://sro.sussex.ac.uk/id/eprint/63036/ Grundy, Gabrielle J, Polo, Luis M, Zeng, Zhihong, Rulten, Stuart L, Hoch, Nicolas C, Pathompong, Paomephan, Xu, Yingqi, Sweet, Steve M, Thorne, Alan W, Oliver, Antony W, Matthews, Steve J, Pearl, Laurence H and Caldecott, Keith W (2016) PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2). Nature Communications, 7 (1). a12404 1-12. ISSN 2041-1723 Fri, 13 May 2016 13:59:23 +0100 http://sro.sussex.ac.uk/id/eprint/60994/ http://sro.sussex.ac.uk/id/eprint/60994/ van der Crabben, Saskia N, Hennus, Marije P, McGregor, Grant, Ritter, Deborah I, Nagamani, Sandesh C S, Wells, Owen S, Harakalova, Magdalena, Chinn, Ivan K, Alt, Aaron, Vondrova, Lucie, Hochstenbach, Ron, van Montfrans, Joris M, Terheggen-Lagro, Suzanne W, van Lieshout, Stef, van Roosmalen, Markus J, Renkens, Ivo, Duran, Karen, Nijman, Isaac J, Kloosterman, Wigard P, Hennekam, Eric, Orange, Jordan S, van Hasselt, Peter M, Wheeler, David A, Palecek, Jan J, Lehmann, Alan R, Oliver, Antony W, Pearl, Laurence H, Plon, Sharon E, Murray, Johanne M and van Haaften, Gijs (2016) Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease. Journal of Clinical Investigation, 126 (8). pp. 2881-2892. ISSN 0021-9738 Fri, 13 May 2016 09:22:09 +0100 http://sro.sussex.ac.uk/id/eprint/60891/ http://sro.sussex.ac.uk/id/eprint/60891/ Densham, Ruth M, Garvin, Alexander J, Stone, Helen R, Strachan, Joanna, Baldock, Robert A, Daza-Martin, Manuel, Fletcher, Alice, Blair-Reed, Sarah, Beesley, James, Johal, Balraj, Pearl, Laurence H, Neely, Robert, Keep, Nicholas H, Watts, Felicity Z and Morris, Joanna R (2016) Human BRCA1-BARD1 ubiquitin ligase activity counters chromatin barriers to DNA resection. Nature Structural and Molecular Biology, 23 (7). pp. 647-655. ISSN 1545-9993 Tue, 26 Apr 2016 09:20:24 +0100 http://sro.sussex.ac.uk/id/eprint/60620/ http://sro.sussex.ac.uk/id/eprint/60620/ Hornyak, Peter, Askwith, Trevor, Walker, Sarah, Komulainen, Emilia, Paradowski, Michael, Pennicott, Lewis E, Bartlett, Edward J, Brissett, Nigel C, Raoof, Ali, Watson, Mandy, Jordan, Allan M, Ogilvie, Donald J, Ward, Simon E, Atack, John R, Pearl, Laurence H, Caldecott, Keith W and Oliver, Antony W (2016) Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2. Biochemical Journal, 473 (13). pp. 1869-1879. ISSN 0264-6021 Wed, 20 Apr 2016 11:04:16 +0100 http://sro.sussex.ac.uk/id/eprint/60563/ http://sro.sussex.ac.uk/id/eprint/60563/ Grundy, Gabrielle J, Rulten, Stuart L, Arribas-Bosacoma, Raquel, Davidson, Kathryn, Kozik, Zuzanna, Oliver, Antony W, Pearl, Laurence H and Caldecott, Keith W (2016) The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins. Nature Communications, 7 (1). a11242. ISSN 2041-1723 Mon, 18 Jan 2016 12:27:11 +0000 http://sro.sussex.ac.uk/id/eprint/59275/ http://sro.sussex.ac.uk/id/eprint/59275/ Jeggo, Penny A, Pearl, Laurence H and Carr, Antony M (2015) DNA repair, genome stability and cancer: a historical perspective. Nature Reviews Cancer, 16 (1). pp. 35-42. ISSN 1474-175X Fri, 15 Jan 2016 11:03:23 +0000 http://sro.sussex.ac.uk/id/eprint/59215/ http://sro.sussex.ac.uk/id/eprint/59215/ Morgan, Rhodri M L, Pal, Mohinder, Roe, S Mark, Pearl, Laurence H and Prodromou, Chrisostomos (2015) Tah1 helix-swap dimerization prevents mixed Hsp90 co-chaperone complexes. Acta Crystallographica Section D: Biological Crystallography, D71. pp. 1197-1206. ISSN 1399-0047 Fri, 15 Jan 2016 10:52:25 +0000 http://sro.sussex.ac.uk/id/eprint/59213/ http://sro.sussex.ac.uk/id/eprint/59213/ Jeggo, Penny A, Pearl, Laurence H and Carr, Antony M (2016) DNA repair, genome stability and cancer: a historical perspective. Nature Reviews Cancer, 16 (1). pp. 35-42. ISSN 1474-1768 Mon, 04 Jan 2016 15:24:18 +0000 http://sro.sussex.ac.uk/id/eprint/58864/ http://sro.sussex.ac.uk/id/eprint/58864/ Baldock, Robert A, Day, Matthew, Wilkinson, Oliver J, Cloney, Ross, Jeggo, Penelope A, Oliver, Antony W, Watts, Felicity Z and Pearl, Laurence H (2015) ATM localization and heterochromatin repair depend on Direct Interaction of the 53BP1-BRCT2 domain with γH2AX. Cell Reports, 13 (10). pp. 2081-2089. ISSN 2211-1247 Fri, 06 Mar 2015 10:46:17 +0000 http://sro.sussex.ac.uk/id/eprint/53247/ http://sro.sussex.ac.uk/id/eprint/53247/ Pearl, Laurence H, Schierz, Amanda C, Ward, Simon E, Al-Lazikani, Bissan and Pearl, Frances M G (2015) Therapeutic opportunities within the DNA damage response. Nature Reviews Cancer, 15 (3). pp. 166-180. ISSN 1474-175X Thu, 05 Mar 2015 08:55:03 +0000 http://sro.sussex.ac.uk/id/eprint/53207/ http://sro.sussex.ac.uk/id/eprint/53207/ Roe, S Mark, Prodromou, Chrisostomos, O'Brien, Ronan, Ladbury, John E, Piper, Peter W and Pearl, Laurence H (1999) Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin. Journal of Medicinal Chemistry, 42 (2). pp. 260-266. ISSN 0022-2623 Thu, 05 Mar 2015 08:47:47 +0000 http://sro.sussex.ac.uk/id/eprint/53206/ http://sro.sussex.ac.uk/id/eprint/53206/ Smith, J R, de Billy, E, Hobbs, S, Powers, M, Prodromou, C, Pearl, L, Clarke, P A and Workman, P (2013) Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteins. Oncogene, 34 (1). pp. 15-26. ISSN 0950-9232 Wed, 25 Feb 2015 10:29:24 +0000 http://sro.sussex.ac.uk/id/eprint/44382/ http://sro.sussex.ac.uk/id/eprint/44382/ Truman, Andrew W, Millson, Stefan H, Nuttall, James M, King, Victoria, Mollapour, Medhi, Prodromou, Chrisostomos, Pearl, Laurence H and Piper, Peter W (2006) Expressed in the yeast Saccharomyces cerevisiae, human ERK5 is a client of the Hsp90 chaperone that complements loss of the Slt2p (Mpk1p) cell integrity stress-activated protein kinase. Eukaryotic Cell, 5 (11). pp. 1914-1924. ISSN 1535-9778 Wed, 25 Feb 2015 10:22:51 +0000 http://sro.sussex.ac.uk/id/eprint/44379/ http://sro.sussex.ac.uk/id/eprint/44379/ Siligardi, Giuliano, Hu, Bin, Panaretou, Barry, Piper, Peter W, Pearl, Laurence H and Prodromou, Chrisostomos (2004) Co-chaperone regulation of conformational switching in the Hsp90 ATPase cycle. Journal of Biological Chemistry, 279 (50). pp. 51989-51998. ISSN 0021-9258 Wed, 25 Feb 2015 09:54:53 +0000 http://sro.sussex.ac.uk/id/eprint/44376/ http://sro.sussex.ac.uk/id/eprint/44376/ Sharp, Swee Y, Boxall, Kathy, Rowlands, Martin, Prodromou, Chrisostomos, Roe, S Mark, Maloney, Alison, Powers, Marissa, Clarke, Paul A, Box, Gary, Sanderson, Sharon, Patterson, Lisa, Matthews, Thomas P, Cheung, Kwai-Ming J, Ball, Karen, Hayes, Angela, Raynaud, Florence, Marais, Richard, Pearl, Laurence, Eccles, Sue, Aherne, Wynne, McDonald, Edward and Workman, Paul (2007) In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors. Cancer Research, 67 (5). pp. 2206-2216. ISSN 0008-5472 Wed, 25 Feb 2015 09:38:18 +0000 http://sro.sussex.ac.uk/id/eprint/44374/ http://sro.sussex.ac.uk/id/eprint/44374/ Salek, Reza M, Williams, Mark A, Prodromou, Chrisostomos, Pearl, Laurence H and Ladbury, John E (2002) Backbone resonance assignments of the 25kD N-terminal ATPase domain from the Hsp90 chaperone. Journal of Biomolecular NMR, 23 (4). pp. 327-328. ISSN 0925-2738 Wed, 25 Feb 2015 09:33:25 +0000 http://sro.sussex.ac.uk/id/eprint/44373/ http://sro.sussex.ac.uk/id/eprint/44373/ Rowlands, Martin G, Newbatt, Yvette M, Prodromou, Chrisostomos, Pearl, Laurence, Workman, Paul and Aherne, Wynne (2004) High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity. Analytical Biochemistry, 327 (2). pp. 176-183. ISSN 0003-2697 Wed, 25 Feb 2015 09:29:46 +0000 http://sro.sussex.ac.uk/id/eprint/44371/ http://sro.sussex.ac.uk/id/eprint/44371/ Roe, S Mark, Ali, Maruf M U, Meyer, Philippe, Vaughan, Cara K, Panaretou, Barry, Piper, Peter W, Prodromou, Chrisostomos and Pearl, Laurence H (2004) The mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37). Cell, 116 (1). pp. 87-98. ISSN 0092-8674 Wed, 25 Feb 2015 09:22:52 +0000 http://sro.sussex.ac.uk/id/eprint/44370/ http://sro.sussex.ac.uk/id/eprint/44370/ Reich, Stephanie, Puckey, Loretto H, Cheetham, Caroline L, Harris, Richard, Ali, Ammar A E, Bhattacharyya, Uma, Maclagan, Kate, Powell, Keith A, Prodromou, Chrisostomos, Pearl, Laurence H, Driscoll, Paul C and Savva, Renos (2006) Combinatorial domain hunting: an effective approach for the identification of soluble protein domains adaptable to high-throughput applications. Protein Science, 15 (10). pp. 2356-2365. ISSN 0961-8368 Wed, 25 Feb 2015 08:55:58 +0000 http://sro.sussex.ac.uk/id/eprint/44356/ http://sro.sussex.ac.uk/id/eprint/44356/ Piper, Peter W, Panaretou, Barry, Millson, Stefan H, Truman, Andrew, Mollapour, Mehdi, Pearl, Laurence and Prodromou, Chrisostomos (2003) Yeast is selectively hypersensitised to heat shock protein 90 (Hsp90)-targetting drugs with heterologous expression of the human Hsp90beta, a property that can be exploited in screens for new Hsp90 chaperone inhibitors. Gene, 302 (1-2). pp. 165-170. ISSN 0378-1119 Wed, 25 Feb 2015 08:43:54 +0000 http://sro.sussex.ac.uk/id/eprint/44355/ http://sro.sussex.ac.uk/id/eprint/44355/ Piper, Peter W, Millson, Stefan H, Mollapour, Mehdi, Panaretou, Barry, Siligardi, Giuliano, Pearl, Laurence H and Prodromou, Chrisostomos (2003) Sensitivity to Hsp90-targeting drugs can arise with mutation to the Hsp90 chaperone, cochaperones and plasma membrane ATP binding cassette transporters of yeast. European Journal of Biochemistry, 270 (23). pp. 4689-4695. ISSN 0014-2956 Wed, 25 Feb 2015 08:39:24 +0000 http://sro.sussex.ac.uk/id/eprint/44353/ http://sro.sussex.ac.uk/id/eprint/44353/ Pearl, Laurence H and Prodromou, Chrisostomos (2006) Structure and mechanism of the Hsp90 molecular chaperone machinery. Annual Review of Biochemistry, 75. pp. 271-294. ISSN 0066-4154 Wed, 25 Feb 2015 07:55:35 +0000 http://sro.sussex.ac.uk/id/eprint/44352/ http://sro.sussex.ac.uk/id/eprint/44352/ Pearl, Laurence H and Prodromou, Chrisostomos (2001) Structure, function, and mechanism of the Hsp90 molecular chaperone. Advances in Protein Chemistry, 59. pp. 157-186. ISSN 0065-3233 Wed, 25 Feb 2015 07:45:52 +0000 http://sro.sussex.ac.uk/id/eprint/44351/ http://sro.sussex.ac.uk/id/eprint/44351/ Pearl, Laurence H and Prodromou, Chrisostomos (2000) Structure and in vivo function of Hsp90. Current Opinion in Structural Biology, 10 (1). pp. 46-51. ISSN 0959-440X Wed, 25 Feb 2015 07:25:56 +0000 http://sro.sussex.ac.uk/id/eprint/44350/ http://sro.sussex.ac.uk/id/eprint/44350/ Panaretou, Barry, Sinclair, Kirsty, Prodromou, Chrisostomos, Johal, Jasvinder, Pearl, Laurence and Piper, Peter W (1999) The Hsp90 of Candida albicans can confer Hsp90 functions in Saccharomyces cerevisiae: a potential model for the processes that generate immunogenic fragments of this molecular chaperone in C. albicans infections. Microbiology, 145 (12). pp. 3455-3463. ISSN 1350-0872 Wed, 25 Feb 2015 07:18:42 +0000 http://sro.sussex.ac.uk/id/eprint/44349/ http://sro.sussex.ac.uk/id/eprint/44349/ Panaretou, Barry, Siligardi, Giuliana, Meyer, Philippe, Maloney, Alison, Sullivan, Janis K, Singh, Shradha, Millson, Stefan H, Clarke, Paul A, Naaby-Hansen, Soren, Stein, Rob, Cramer, Rainer, Mollapour, Mehdi, Workman, Paul, Piper, Peter W, Pearl, Laurence H and Prodromou, Chrisostomos (2002) Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1. Molecular Cell, 10 (6). pp. 1307-1318. ISSN 1097-2765 Wed, 25 Feb 2015 07:13:50 +0000 http://sro.sussex.ac.uk/id/eprint/44348/ http://sro.sussex.ac.uk/id/eprint/44348/ Panaretou, Barry, Prodromou, Chrisostomos, Roe, S Mark, O'Brien, Ronan, Ladbury, John E, Piper, Peter W and Pearl, Laurence H (1998) ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo. EMBO Journal, 17 (16). pp. 4829-4836. ISSN 0261-4189 Wed, 25 Feb 2015 07:11:35 +0000 http://sro.sussex.ac.uk/id/eprint/44344/ http://sro.sussex.ac.uk/id/eprint/44344/ Millson, Stefan H, Truman, Andrew W, Wolfram, Francis, King, Victoria, Panaretou, Barry, Prodromou, Chrisostomos, Pearl, Laurence H and Piper, Peter W (2004) Investigating the protein-protein interactions of the yeast Hsp90 chaperone system by two-hybrid analysis: potential uses and limitations of this approach. Cell Stress and Chaperones, 9 (4). pp. 359-368. ISSN 1355-8145 Wed, 25 Feb 2015 07:08:35 +0000 http://sro.sussex.ac.uk/id/eprint/44343/ http://sro.sussex.ac.uk/id/eprint/44343/ Millson, Stefan H, Truman, Andrew W, King, Victoria, Prodromou, Chrisostomos, Pearl, Laurence H and Piper, Peter W (2005) A two-hybrid screen of the yeast proteome for Hsp90 interactors uncovers a novel Hsp90 chaperone requirement in the activity of a stress-activated mitogen-activated protein kinase, Slt2p (Mpk1p). Eukaryotic Cell, 4 (5). pp. 849-860. ISSN 1535-9778 Wed, 25 Feb 2015 07:05:01 +0000 http://sro.sussex.ac.uk/id/eprint/44341/ http://sro.sussex.ac.uk/id/eprint/44341/ Meyer, Philippe, Prodromou, Chrisostomos, Liao, Chunyan, Hu, Bin, Roe, S Mark, Vaughan, Cara K, Vlasic, Ignacija, Panaretou, Barry, Piper, Peter W and Pearl, Laurence H (2004) Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery. EMBO Journal, 23 (6). pp. 1402-1410. ISSN 0261-4189 Wed, 25 Feb 2015 07:01:42 +0000 http://sro.sussex.ac.uk/id/eprint/44340/ http://sro.sussex.ac.uk/id/eprint/44340/ Meyer, Philipe, Prodromou, Chrisostomos, Hu, Bin, Vaughan, Cara, Roe, S Mark, Panaretou, Barry, Piper, Peter W and Pearl, Laurence H (2003) Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions. Molecular Cell, 11 (3). pp. 647-658. ISSN 1097-2765 Wed, 25 Feb 2015 06:56:34 +0000 http://sro.sussex.ac.uk/id/eprint/44338/ http://sro.sussex.ac.uk/id/eprint/44338/ Hu, Bin, Liao, Chunyan, Millson, Stefan H, Mollapour, Mehdi, Prodromou, Chrisostomos, Pearl, Laurence H, Piper, Peter W and Panaretou, Barry (2005) Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex. Molecular Microbiology, 55 (6). pp. 1735-1750. ISSN 0950-382X Wed, 25 Feb 2015 06:50:34 +0000 http://sro.sussex.ac.uk/id/eprint/44331/ http://sro.sussex.ac.uk/id/eprint/44331/ Aherne, Wynne, Maloney, Alison, Prodromou, Chrisostomos, Rowlands, Martin G, Hardcastle, Anthea, Boxall, Katherine, Clarke, Paul, Walton, Michael I, Pearl, Laurence and Workman, Paul (2003) Assays for HSP90 and inhibitors. Methods in Molecular Medicine, 85. pp. 149-161. ISSN 1543-1894 Tue, 24 Feb 2015 17:54:06 +0000 http://sro.sussex.ac.uk/id/eprint/44367/ http://sro.sussex.ac.uk/id/eprint/44367/ Prodromou, Chrisostomos, Siligardi, Giuliano, O'Brien, Ronan, Woolfson, Derek N, Regan, Lynne, Panaretou, Barry, Ladbury, John E, Piper, Peter W and Pearl, Laurence H (1999) Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones. EMBO Journal, 18 (3). pp. 754-762. ISSN 0261-4189 Tue, 24 Feb 2015 17:49:12 +0000 http://sro.sussex.ac.uk/id/eprint/44365/ http://sro.sussex.ac.uk/id/eprint/44365/ Prodromou, Chrisostomos, Roe, S Mark, Piper, Peter W and Pearl, Laurence H (1997) A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone. Nature Structural Biology, 4 (6). pp. 477-482. ISSN 1072-8368 Tue, 24 Feb 2015 17:46:26 +0000 http://sro.sussex.ac.uk/id/eprint/44364/ http://sro.sussex.ac.uk/id/eprint/44364/ Prodromou, Chrisostomos, Roe, S Mark, O'Brien, Ronan, Ladbury, John E, Piper, Peter W and Pearl, Laurence H (1997) Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone. Cell, 90 (1). pp. 65-75. ISSN 0092-8674 Tue, 24 Feb 2015 17:43:21 +0000 http://sro.sussex.ac.uk/id/eprint/44363/ http://sro.sussex.ac.uk/id/eprint/44363/ Prodromou, Chrisostomos, Piper, Peter W and Pearl, Laurence H (1996) Expression and crystallization of the yeast Hsp82 chaperone, and preliminary X-ray diffraction studies of the amino-terminal domain. Proteins, 25 (4). pp. 517-522. ISSN 0887-3585 Tue, 24 Feb 2015 17:41:13 +0000 http://sro.sussex.ac.uk/id/eprint/44362/ http://sro.sussex.ac.uk/id/eprint/44362/ Prodromou, Chrisostomos and Pearl, Laurence H (2003) Structure and functional relationships of Hsp90. Current Cancer Drug Targets, 3 (5). pp. 301-323. ISSN 1568-0096 Tue, 24 Feb 2015 17:38:42 +0000 http://sro.sussex.ac.uk/id/eprint/44361/ http://sro.sussex.ac.uk/id/eprint/44361/ Prodromou, Chrisostomos and Pearl, Laurence H (1992) Recursive PCR: a novel technique for total gene synthesis. Protein Engineering, Design and Selection, 5 (8). pp. 827-829. ISSN 1741-0126 Tue, 24 Feb 2015 17:30:27 +0000 http://sro.sussex.ac.uk/id/eprint/44360/ http://sro.sussex.ac.uk/id/eprint/44360/ Prodromou, Chrisostomos, Panaretou, Barry, Chohan, Shahzad, Siligardi, Giuliano, O'Brien, Ronan, Ladbury, John E, Roe, S Mark, Piper, Peter W and Pearl, Laurence H (2000) The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domains. EMBO Journal, 19 (16). pp. 4383-92. ISSN 0261-4189 Tue, 24 Feb 2015 15:54:39 +0000 http://sro.sussex.ac.uk/id/eprint/44377/ http://sro.sussex.ac.uk/id/eprint/44377/ Sharp, Swee Y, Prodromou, Chrisostomos, Boxall, Kathy, Powers, Marissa V, Holmes, Joanna L, Box, Gary, Matthews, Thomas P, Cheung, Kwai-Ming J, Kalusa, Andrew, James, Karen, Hayes, Angela, Hardcastle, Anthea, Dymock, Brian, Brough, Paul A, Barril, Xavier, Cansfield, Julie E, Wright, Lisa, Surgenor, Allan, Foloppe, Nicolas, Hubbard, Roderick E, Aherne, Wynne, Pearl, Laurence, Jones, Keith, McDonald, Edward, Raynaud, Florence, Eccles, Sue, Drysdale, Martin and Workman, Paul (2007) Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues. Molecular Cancer Therapeutics, 6 (4). pp. 1198-1211. ISSN 1535-7163 Tue, 24 Feb 2015 15:50:18 +0000 http://sro.sussex.ac.uk/id/eprint/44380/ http://sro.sussex.ac.uk/id/eprint/44380/ Siligardi, Giuliano, Panaretou, Barry, Meyer, Philippe, Singh, Shradha, Woolfson, Derek N, Piper, Peter W, Pearl, Laurence H and Prodromou, Chrisostomos (2002) Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37. Journal of Biological Chemistry, 277 (23). pp. 20151-20159. ISSN 0021-9258 Tue, 24 Feb 2015 15:22:38 +0000 http://sro.sussex.ac.uk/id/eprint/44386/ http://sro.sussex.ac.uk/id/eprint/44386/ Vaughan, Cara K, Gohlke, Ulrich, Sobott, Frank, Good, Valerie M, Ali, Maruf M U, Prodromou, Chrisostomos, Robinson, Carol V, Saibil, Helen R and Pearl, Laurence H (2006) Structure of an Hsp90-Cdc37-Cdk4 complex. Molecular Cell, 23 (5). pp. 697-707. ISSN 1097-2765 Tue, 24 Feb 2015 15:20:06 +0000 http://sro.sussex.ac.uk/id/eprint/44391/ http://sro.sussex.ac.uk/id/eprint/44391/ Zhang, Minghao, Windheim, Mark, Roe, S Mark, Peggie, Mark, Cohen, Philip, Prodromou, Chrisostomos and Pearl, Laurence H (2005) Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex. Molecular Cell, 20 (4). pp. 525-538. ISSN 1097-2765 Tue, 24 Feb 2015 15:08:28 +0000 http://sro.sussex.ac.uk/id/eprint/44389/ http://sro.sussex.ac.uk/id/eprint/44389/ Wheeler, Vanessa C, Prodromou, Chrisostomos, Pearl, Laurence H, Williamson, Robert and Coutelle, Charles (1996) Synthesis of a modified gene encoding human ornithine transcarbamylase for expression in mammalian mitochondrial and universal translation systems: a novel approach towards correction of a genetic defect. Gene, 169 (2). pp. 251-255. ISSN 0378-1119 Tue, 24 Feb 2015 15:04:51 +0000 http://sro.sussex.ac.uk/id/eprint/44392/ http://sro.sussex.ac.uk/id/eprint/44392/ Zhang, Ming-Qiang, Gaisser, Sabine, Nur-E-Alam, Mohammad, Sheehan, Lesley S, Vousden, William A, Gaitatzis, Nikolaos, Peck, Gerrard, Coates, Nigel J, Moss, Steven J, Radzom, Markus, Foster, Teresa A, Sheridan, Rose M, Gregory, Matthew A, Roe, Susan M, Prodromou, Chrisostomos, Pearl, Laurence, Boyd, Susan M, Wilkinson, Barrie and Martin, Christine J (2008) Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors. Journal of Medicinal Chemistry, 51 (18). pp. 5494-5497. ISSN 0022-2623 Tue, 30 Sep 2014 14:41:44 +0100 http://sro.sussex.ac.uk/id/eprint/50437/ http://sro.sussex.ac.uk/id/eprint/50437/ Meier, Christoph, Brookings, Daniel C, Ceska, Thomas A, Doyle, Carl, Gong, Haiping, McMillan, David, Saville, Giles P, Mushtaq, Adeel, Knight, David, Reich, Stefanie, Pearl, Laurence H, Powell, Keith A, Savva, Renos and Allen, Rodger A (2012) Engineering human MEK-1 for structural studies: A case study of combinatorial domain hunting. Journal of Structural Biology, 177 (2). pp. 329-334. ISSN 1095-8657 Tue, 30 Sep 2014 14:35:49 +0100 http://sro.sussex.ac.uk/id/eprint/50440/ http://sro.sussex.ac.uk/id/eprint/50440/ Morris, Edward P, Rivera-Calzada, Angel, da Fonseca, Paula C A, Llorca, Oscar, Pearl, Laurence H and Spagnolo, Laura (2011) Evidence for a remodelling of DNA-PK upon autophosphorylation from electron microscopy studies. Nucleic Acids Research, 39 (13). pp. 5757-5767. ISSN 1362-4962 Tue, 30 Sep 2014 12:29:39 +0100 http://sro.sussex.ac.uk/id/eprint/50442/ http://sro.sussex.ac.uk/id/eprint/50442/ Cuomo, Maria Emanuela, Platt, Georgina M, Pearl, Laurence H and Mittnacht, Sibylle (2011) Cyclin-cyclin-dependent kinase regulatory response is linked to substrate recognition. Journal of Biological Chemistry, 286 (11). pp. 9713-9725. ISSN 0021-9258 Tue, 30 Sep 2014 12:24:58 +0100 http://sro.sussex.ac.uk/id/eprint/50441/ http://sro.sussex.ac.uk/id/eprint/50441/ Mollapour, Mehdi, Tsutsumi, Shinji, Truman, Andrew W, Xu, Wanping, Vaughan, Cara K, Beebe, Kristin, Konstantinova, Anna, Vourganti, Srinivas, Panaretou, Barry, Piper, Peter W, Trepel, Jane B, Prodromou, Chrisostomos, Pearl, Laurence H and Neckers, Len (2011) Threonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activity. Molecular Cell, 41 (6). pp. 672-681. ISSN 1097-2765 Tue, 30 Sep 2014 11:35:31 +0100 http://sro.sussex.ac.uk/id/eprint/49376/ http://sro.sussex.ac.uk/id/eprint/49376/ Peters, Nicholas E, Ferguson, Brian J, Mazzon, Michela, Fahy, Aodhnait S, Krysztofinska, Ewelina, Arribas-Bosacoma, Raquel, Pearl, Laurence H, Ren, Hongwei and Smith, Geoffrey L (2013) A mechanism for the inhibition of DNA-PK-mediated DNA sensing by a virus. PLoS Pathogens, 9 (10). e1003649. ISSN 1553-7374 Wed, 06 Aug 2014 12:46:53 +0100 http://sro.sussex.ac.uk/id/eprint/49499/ http://sro.sussex.ac.uk/id/eprint/49499/ Walker, Sarah, Meisenberg, Cornelia, Bibby, Rachel A, Askwith, Trevor, Williams, Gareth, Rininsland, Frauke H, Pearl, Laurence H, Oliver, Antony W, El-Khamisy, Sherif, Ward, Simon and Atack, John R (2014) Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors. Analytical Biochemistry, 454. pp. 17-22. ISSN 0003-2697 Wed, 23 Jul 2014 10:30:04 +0100 http://sro.sussex.ac.uk/id/eprint/49374/ http://sro.sussex.ac.uk/id/eprint/49374/ Pal, Mohinder, Morgan, Marc, Phelps, Sarah E L, Roe, S Mark, Parry-Morris, Sarah, Downs, Jessica, Polier, Sigrun, Pearl, Laurence and Prodromou, Chrisostomos (2014) Structural basis for phosphorylation-dependent recruitment of tel2 to hsp90 by pih1. Structure, 22 (6). pp. 805-818. ISSN 1878-4186 Fri, 04 Oct 2013 11:28:46 +0100 http://sro.sussex.ac.uk/id/eprint/46583/ http://sro.sussex.ac.uk/id/eprint/46583/ Qu, Meng, Rappas, Mathieu, Wardlaw, Christopher P, Garcia, Valerie, Ren, Jing-Yi, Day, Matthew, Carr, Antony M, Oliver, Antony, Du, Li-Lin and Pearl, Laurence (2013) Phosphorylation-dependent assembly and coordination of the DNA damage checkpoint apparatus by Rad4TopBP1. Molecular Cell, 51 (6). pp. 723-736. ISSN 1097-2765 Tue, 03 Sep 2013 08:13:56 +0100 http://sro.sussex.ac.uk/id/eprint/45982/ http://sro.sussex.ac.uk/id/eprint/45982/ Chambers, Anna L, Pearl, Laurence H, Oliver, Antony W and Downs, Jessica A (2013) The BAH domain of Rsc2 is a histone H3 binding domain. Nucleic Acids Research, 41 (19). pp. 9168-9182. ISSN 0305-1048 Tue, 26 Mar 2013 09:41:20 +0000 http://sro.sussex.ac.uk/id/eprint/44119/ http://sro.sussex.ac.uk/id/eprint/44119/ Polier, Sigrun, Samant, Rahul S, Clarke, Paul A, Workman, Paul, Prodromou, Chrisostomos and Pearl, Laurence H (2013) ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system. Nature Chemical Biology, 9 (5). pp. 307-312. ISSN 1552-4450 Tue, 19 Jun 2012 09:32:23 +0100 http://sro.sussex.ac.uk/id/eprint/39663/ http://sro.sussex.ac.uk/id/eprint/39663/ Ali, Ammar A E, Timinszky, Gyula, Arribas-Bosacoma, Raquel, Kozlowski, Marek, Hassa, Paul O, Hassler, Markus, Ladurner, Andreas G, Pearl, Laurence H and Oliver, Antony W (2012) The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks. Nature Structural & Molecular Biology, 9 (7). pp. 685-692. ISSN 1545-9985 Wed, 18 Apr 2012 09:30:35 +0100 http://sro.sussex.ac.uk/id/eprint/38565/ http://sro.sussex.ac.uk/id/eprint/38565/ Garces, Fernando, Pearl, Laurence H. and Oliver, Antony W. (2011) The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase. Molecular Cell, 44 (3). 385 - 396. ISSN 1097-2765 Mon, 06 Feb 2012 21:24:45 +0000 http://sro.sussex.ac.uk/id/eprint/31131/ http://sro.sussex.ac.uk/id/eprint/31131/ Oliver, Antony W, Swift, Sally, Lord, Christopher J, Ashworth, Alan and Pearl, Laurence H (2009) Structural basis for recruitment of BRCA2 by PALB2. EMBO Reports, 10 (9). pp. 990-996. ISSN 1469-221X Mon, 06 Feb 2012 21:14:09 +0000 http://sro.sussex.ac.uk/id/eprint/30385/ http://sro.sussex.ac.uk/id/eprint/30385/ Millson, Stefan H, Vaughan, Cara K, Zhai, Chao, Ali, Maruf M U, Panaretou, Barry, Piper, Peter W, Pearl, Laurence H and Prodromou, Chrisostomos (2008) Chaperone ligand-discrimination by the TPR-domain protein Tah1. Biochemical Journal, 413. pp. 261-268. ISSN 0264-6021 Mon, 06 Feb 2012 21:14:06 +0000 http://sro.sussex.ac.uk/id/eprint/30379/ http://sro.sussex.ac.uk/id/eprint/30379/ Proisy, Nicolas, Sharp, Swee Y, Boxall, Kathy, Connelly, Stephen, Roe, S Mark, Prodromou, Chrisostomos, Slawin, Alexandra M Z, Pearl, Laurence H, Workman, Paul and Moody, Christopher J (2006) Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol. Chemistry & Biology, 13 (11). pp. 1203-1215. ISSN 1074-5521 Mon, 06 Feb 2012 21:12:59 +0000 http://sro.sussex.ac.uk/id/eprint/30241/ http://sro.sussex.ac.uk/id/eprint/30241/ Day, James E H, Sharp, Swee Y, Rowlands, Martin G, Aherne, Wynne, Lewis, William, Roe, S Mark, Prodromou, Chrisostomos, Pearl, Laurence H, Workman, Paul and Moody, Christopher J (2010) Inhibition of Hsp90 with resorcylic acid macrolactones: synthesis and binding studies. Chemistry - A European Journal, 16 (34). pp. 10366-10372. ISSN 0947-6539 Mon, 06 Feb 2012 21:10:46 +0000 http://sro.sussex.ac.uk/id/eprint/29985/ http://sro.sussex.ac.uk/id/eprint/29985/ Anderson, Victoria E, Walton, Michael I, Eve, Paul D, Boxall, Katherine J, Antoni, Laurent, Caldwell, John J, Aherne, Wynne, Pearl, Laurence H, Oliver, Antony W, Collins, Ian and Garrett, Michelle D (2011) CCT241533 Is a Potent and Selective Inhibitor of CHK2 that Potentiates the Cytotoxicity of PARP Inhibitors. Cancer Research, 71 (2). pp. 463-472. ISSN 0008-5472 Mon, 06 Feb 2012 21:06:08 +0000 http://sro.sussex.ac.uk/id/eprint/29483/ http://sro.sussex.ac.uk/id/eprint/29483/ Ali, Ammar A. E., Jukes, Rachel M., Pearl, Laurence H. and Oliver, Antony W. (2009) Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK. Nucleic Acids Research, 37 (5). pp. 1701-1712. ISSN 0305-1048 Mon, 06 Feb 2012 21:02:24 +0000 http://sro.sussex.ac.uk/id/eprint/29241/ http://sro.sussex.ac.uk/id/eprint/29241/ Prodromou, Chrisostomos, Nuttall, James M, Millson, Stefan H, Roe, S Mark, Sim, Tiow-Suan, Tan, Doreen, Workman, Paul, Pearl, Laurence H and Piper, Peter W (2009) Structural basis of the radicicol resistance displayed by a fungal hsp90. ACS Chemical Biology, 4 (4). pp. 289-297. ISSN 1554-8929 Mon, 06 Feb 2012 21:00:29 +0000 http://sro.sussex.ac.uk/id/eprint/29080/ http://sro.sussex.ac.uk/id/eprint/29080/ Mollapour, Mehdi, Tsutsumi, Shinji, Donnelly, Alison C, Beebe, Kristin, Tokita, Mari J, Lee, Min-Jung, Lee, Sunmin, Morra, Giulia, Bourboulia, Dimitra, Scroggins, Bradley T, Colombo, Giorgio, Blagg, Brian S, Panaretou, Barry, Stetler-Stevenson, William G, Trepel, Jane B, Piper, Peter W, Prodromou, Chrisostomos, Pearl, Laurence H and Neckers, Len (2010) Swe1(Wee1)-Dependent Tyrosine Phosphorylation of Hsp90 Regulates Distinct Facets of Chaperone Function. Molecular Cell, 37 (3). pp. 333-343. ISSN 1097-2765 Mon, 06 Feb 2012 21:00:16 +0000 http://sro.sussex.ac.uk/id/eprint/29063/ http://sro.sussex.ac.uk/id/eprint/29063/ Zhang, Minghao, Botër, Marta, Li, Kuoyu, Kadota, Yasuhiro, Panaretou, Barry, Prodromou, Chrisostomos, Shirasu, Ken and Pearl, Laurence H (2008) Structural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexes. EMBO Journal, 27 (20). pp. 2789-2798. ISSN 0261-4189 Mon, 06 Feb 2012 20:56:58 +0000 http://sro.sussex.ac.uk/id/eprint/28806/ http://sro.sussex.ac.uk/id/eprint/28806/ Oliver, Antony W, Jones, Sarah A, Roe, Stephen Mark, Matthews, Steve, Goodwin, Graham H and Pearl, Laurence H (2005) Crystal structure of the proximal BAH domain of the polybromo protein. Biochemical Journal, 389 (3). pp. 657-664. ISSN 0264-6021 Mon, 06 Feb 2012 20:50:58 +0000 http://sro.sussex.ac.uk/id/eprint/28431/ http://sro.sussex.ac.uk/id/eprint/28431/ Oliver, A W, Amé, J C, Roe, S M, Good, V, de Murcia, G and Pearl, L H (2004) Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2. Nucleic Acids Research, 32 (2). pp. 456-464. ISSN 0305-1048 Mon, 06 Feb 2012 20:46:18 +0000 http://sro.sussex.ac.uk/id/eprint/28031/ http://sro.sussex.ac.uk/id/eprint/28031/ Ali, MMU, Bagratuni, T, Davenport, EL, Nowak, PR, Silva-Santiestaban, MC, Hardcastle, A, McAndrews, C, Rowlands, MG, Morgan, GJ, Aherne, W, Collins, I, Davies, FE and Pearl, Laurence (2011) Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response. EMBO Journal, 30 (5). pp. 894-905. ISSN 0261-4189 Mon, 06 Feb 2012 20:44:32 +0000 http://sro.sussex.ac.uk/id/eprint/27828/ http://sro.sussex.ac.uk/id/eprint/27828/ Caldwell, John J, Welsh, Emma J, Matjissen, Cornelis, Anderson, Victoria E, Antoni, Laurent, Boxall, Kathy, Urban, Frederique, Hayes, Angela, Raynaud, Florence I, Rigoreau, Laurent J M, Raynham, Tony, Aherne, G Wynne, Pearl, Laurence H, Oliver, Antony W, Garrett, Michelle D and Collins, Ian (2011) Structure-Based Design of Potent and Selective 2-(Quinazolin-2-yl)phenol Inhibitors of Checkpoint Kinase 2. Journal of Medicinal Chemistry, 54 (2). pp. 580-590. ISSN 0022-2623 Mon, 06 Feb 2012 20:36:48 +0000 http://sro.sussex.ac.uk/id/eprint/26953/ http://sro.sussex.ac.uk/id/eprint/26953/ Pike, Ashley C W, Rellos, Peter, Niesen, Frank H, Turnbull, Andrew, Oliver, Antony W, Parker, Sirlester A, Turk, Benjamin E, Pearl, Laurence H and Knapp, Stefan (2008) Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites. EMBO Journal, 27 (4). pp. 704-714. ISSN 0261-4189 Mon, 06 Feb 2012 20:36:29 +0000 http://sro.sussex.ac.uk/id/eprint/26922/ http://sro.sussex.ac.uk/id/eprint/26922/ Martin, Christine J, Gaisser, Sabine, Challis, Iain R, Carletti, Isabelle, Wilkinson, Barrie, Gregory, Matthew, Prodromou, Chrisostomos, Roe, S Mark, Pearl, Laurence H, Boyd, Susan M and Zhang, Ming-Qiang (2008) Molecular characterization of macbecin as an Hsp90 inhibitor. Journal of Medicinal Chemistry, 51 (9). pp. 2853-2857. ISSN 0022-2623 Mon, 06 Feb 2012 20:36:27 +0000 http://sro.sussex.ac.uk/id/eprint/26918/ http://sro.sussex.ac.uk/id/eprint/26918/ Nilapwar, Sanjay, Williams, Eleanor, Fu, Christopher, Prodromou, Chrisostomos, Pearl, Laurence H, Williams, Mark A and Ladbury, John E (2009) Structural–Thermodynamic Relationships of Interactions in the N-Terminal ATP-Binding Domain of Hsp90. Journal of Molecular Biology, 392 (4). pp. 923-936. ISSN 0022-2836 Mon, 06 Feb 2012 20:34:08 +0000 http://sro.sussex.ac.uk/id/eprint/26664/ http://sro.sussex.ac.uk/id/eprint/26664/ Zhang, Minghao, Kadota, Yasuhiro, Prodromou, Chrisostomos, Shirasu, Ken and Pearl, Laurence H (2010) Structural basis for assembly of Hsp90-Sgt1-CHORD protein complexes: implications for chaperoning of NLR innate immunity receptors. Molecular Cell, 39 (2). pp. 269-281. ISSN 1097-2765 Mon, 06 Feb 2012 20:33:03 +0000 http://sro.sussex.ac.uk/id/eprint/26538/ http://sro.sussex.ac.uk/id/eprint/26538/ Vaughan, Cara K, Mollapour, Mehdi, Smith, Jennifer R, Truman, Andrew, Hu, Bin, Good, Valerie M, Panaretou, Barry, Neckers, Len, Clarke, Paul A, Workman, Paul, Piper, Peter W, Prodromou, Chrisostomos and Pearl, Laurence H (2008) Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37. Molecular Cell, 31 (6). pp. 886-895. ISSN 1097-2765 Mon, 06 Feb 2012 20:31:36 +0000 http://sro.sussex.ac.uk/id/eprint/26377/ http://sro.sussex.ac.uk/id/eprint/26377/ Walliser, C, Retlich, M, Wollny, C, Harris, R, Everett, K L, Josephs, M B, Roe, S M, Vatter, P, Christow, C, Rodrigues-Lima, F, Pearl, L H, Driscoll, P C, Katan, M, Gierschik, P and Bunney, T D (2008) Rac2 regulates its effector phospholipase C-gamma 2 through interaction with a split PH domain. In: 49th Annual Meeting German-Society-for-Experimental-and-Clinical-Pharmacology-and-Toxicology, Mainz, GERMANY. Mon, 06 Feb 2012 20:28:06 +0000 http://sro.sussex.ac.uk/id/eprint/26025/ http://sro.sussex.ac.uk/id/eprint/26025/ Maclagan, Kate, Tommasi, Rita, Laurine, Emmanuelle, Prodromou, Chrisostomos, Driscoll, Paul C, Pearl, Laurence H, Reich, Stefanie and Savva, Renos (2011) A combinatorial method to enable detailed investigation of protein–protein interactions. Future Medicinal Chemistry, 3 (3). pp. 271-282. ISSN 1756-8919 Mon, 06 Feb 2012 20:27:25 +0000 http://sro.sussex.ac.uk/id/eprint/25977/ http://sro.sussex.ac.uk/id/eprint/25977/ Hawkins, Thomas A, Haramis, Anna-Pavlina, Etard, Christelle, Prodromou, Chrisostomos, Vaughan, Cara K, Ashworth, Rachel, Ray, Saikat, Behra, Martine, Holder, Nigel, Talbot, William S, Pearl, Laurence H, Strähle, Uwe and Wilson, Stephen W (2008) The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis. Development, 135 (6). pp. 1147-1156. ISSN 0950-1991 Mon, 06 Feb 2012 20:14:27 +0000 http://sro.sussex.ac.uk/id/eprint/24886/ http://sro.sussex.ac.uk/id/eprint/24886/ Woodbine, Lisa, Grigoriadoub, Sofia, Goodarzi, Aaron A, Riballo, Enriqueta, Tape, Christopher, Oliver, Antony W, van Zelm, Menno C, Buckland, Matthew S, Davies, E Graham, Pearl, Laurence H and Jeggo, Penny A (2010) An Artemis polymorphic variant reduces Artemis activity and confers cellular radiosensitivity. DNA Repair, 9 (9). pp. 1003-1010. ISSN 1568-7864 Mon, 06 Feb 2012 20:13:26 +0000 http://sro.sussex.ac.uk/id/eprint/24775/ http://sro.sussex.ac.uk/id/eprint/24775/ Cheung, Kwai-Ming J, Matthews, Thomas P, James, Karen, Rowlands, Martin G, Boxall, Katherine J, Sharp, Swee Y, Maloney, Alison, Roe, S Mark, Prodromou, Chrisostomos, Pearl, Laurence H, Aherne, G Wynne, McDonald, Edward and Workman, Paul (2005) The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors. Bioorganic and Medicinal Chemistry Letters, 15 (14). pp. 3338-3343. ISSN 0960-894X Mon, 06 Feb 2012 20:13:04 +0000 http://sro.sussex.ac.uk/id/eprint/24726/ http://sro.sussex.ac.uk/id/eprint/24726/ Bunney, Tom D, Opaleye, Olanivi, Roe, S Mark, Vatter, Petra, Baxendale, Rhona W, Walliser, Claudia, Everett, Katy L, Josephs, Michelle B, Christow, Carolin, Rodrigues-Lima, Fernando, Gierschik, Peter, Pearl, Laurence H and Katan, Matilda (2009) Structural Insights into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2. Molecular Cell, 34 (2). pp. 223-233. ISSN 1097-2765 Mon, 06 Feb 2012 20:12:49 +0000 http://sro.sussex.ac.uk/id/eprint/24696/ http://sro.sussex.ac.uk/id/eprint/24696/ Richardson, Christopher J, Gao, Qiong, Mitsopoulous, Costas, Zvelebil, Marketa, Pearl, Laurence H and Pearl, Frances M G (2009) MoKCa database - mutations of kinases in cancer. Nucleic Acids Research, 37 (S1). D824-D831. ISSN 0305-1048 Mon, 06 Feb 2012 19:56:41 +0000 http://sro.sussex.ac.uk/id/eprint/23111/ http://sro.sussex.ac.uk/id/eprint/23111/ Oliver, Antony W, Paul, Angela, Boxall, Katherine J, Barrie, S Elaine, Aherne, G Wynne, Garrett, Michelle D, Mittnacht, Sibylle and Pearl, Laurence H (2006) Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange. EMBO Journal, 25 (13). pp. 3179-3190. ISSN 0261-4189 Mon, 06 Feb 2012 19:52:24 +0000 http://sro.sussex.ac.uk/id/eprint/22675/ http://sro.sussex.ac.uk/id/eprint/22675/ Rowlands, Martin, McAndrew, Craig, Prodromou, Chris, Pearl, Laurence, Kalusa, Andrew, Jones, Keith, Workman, Paul and Aherne, Wynne (2010) Detection of the ATPase Activity of the Molecular Chaperones Hsp90 and Hsp72 Using the Transcreener™ ADP Assay Kit. Journal of Biomolecular Screening, 15 (3). pp. 279-86. ISSN 1087-0571 Mon, 06 Feb 2012 19:50:21 +0000 http://sro.sussex.ac.uk/id/eprint/22440/ http://sro.sussex.ac.uk/id/eprint/22440/ Boos, Dominik, Sanchez-Pulido, Luis, Rappas, Mathieu, Pearl, Laurence H, Oliver, Antony W, Ponting, Chris P and Diffley, John F X (2011) Regulation of DNA replication through Sld3-Dpb11 interaction is conserved from yeast to humans. Current Biology, 21 (13). pp. 1152-1157. ISSN 0960-9822 Mon, 06 Feb 2012 19:50:18 +0000 http://sro.sussex.ac.uk/id/eprint/22436/ http://sro.sussex.ac.uk/id/eprint/22436/ Day, James E H, Sharp, Swee Y, Rowlands, Martin G, Aherne, Wynne, Hayes, Angela, Raynaud, Florence I, Lewis, William, Roe, S Mark, Prodromou, Chrisostomos, Pearl, Laurence H, Workman, Paul and Moody, Christopher J (2011) Targeting the Hsp90 Molecular Chaperone with Novel Macrolactams. Synthesis, Structural, Binding, and Cellular Studies. ACS Chemical Biology, 6 (12). pp. 1339-1347. ISSN 1554-8929 Mon, 06 Feb 2012 19:39:50 +0000 http://sro.sussex.ac.uk/id/eprint/21690/ http://sro.sussex.ac.uk/id/eprint/21690/ Pearl, Laurence H, Prodromou, Chrisostomos and Workman, Paul (2008) The Hsp90 molecular chaperone: an open and shut case for treatment. Biochemical Journal, 410. pp. 439-453. ISSN 0264-6021 Mon, 06 Feb 2012 18:53:49 +0000 http://sro.sussex.ac.uk/id/eprint/18817/ http://sro.sussex.ac.uk/id/eprint/18817/ Ali, Maruf M U, Roe, S Mark, Vaughan, Cara K, Meyer, Phillipe, Panaretou, Barry, Piper, Peter W, Prodromou, Chrisostomos and Pearl, Laurence H (2006) Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex. Nature, 440. pp. 1013-1017. ISSN 0028-0836 Mon, 06 Feb 2012 18:46:39 +0000 http://sro.sussex.ac.uk/id/eprint/18271/ http://sro.sussex.ac.uk/id/eprint/18271/ Oliver, Antony W, Knapp, Stefan and Pearl, Laurence H (2007) Activation segment exchange: a common mechanism of kinase autophosphorylation? Trends in Biochemical Science, 32 (8). pp. 351-356. Mon, 06 Feb 2012 18:37:37 +0000 http://sro.sussex.ac.uk/id/eprint/17462/ http://sro.sussex.ac.uk/id/eprint/17462/ Brough, Paul A., Pearl, Laurence H., Prodromou, Chrisostomos and et al, (2008) 4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer. Journal of Medicinal Chemistry, 51 (2). pp. 196-218. ISSN 0022-2623 Mon, 06 Feb 2012 18:36:35 +0000 http://sro.sussex.ac.uk/id/eprint/17382/ http://sro.sussex.ac.uk/id/eprint/17382/ Recuero-Checa, María A, Doré, Andrew S, Arias-Palomo, Ernesto, Rivera-Calzada, Angel, Scheres, Sjors H W, Maman, Joseph D, Pearl, Laurence H and Llorca, Oscar (2009) Electron microscopy of Xrcc4 and the DNA ligase IV-Xrcc4 DNA repair complex. DNA Repair, 8 (12). pp. 1380-1389. ISSN 1568-7864 Mon, 06 Feb 2012 18:35:26 +0000 http://sro.sussex.ac.uk/id/eprint/17276/ http://sro.sussex.ac.uk/id/eprint/17276/ Eccles, Suzanne A, Massey, Andy, Raynaud, Florence I, Sharp, Swee Y, Box, Gary, Valenti, Melanie, Patterson, Lisa, de Haven Brandon, Alexis, Gowan, Sharon, Boxall, Frances, Aherne, Wynne, Rowlands, Martin, Hayes, Angela, Martins, Vanessa, Urban, Frederique, Boxall, Kathy, Prodromou, Chrisostomos, Pearl, Laurence, James, Karen, Matthews, Thomas P, Cheung, Kwai-Ming, Kalusa, Andrew, Jones, Keith, McDonald, Edward, Barril, Xavier, Brough, Paul A, Cansfield, Julie E, Dymock, Brian, Drysdale, Martin J, Finch, Harry, Howes, Rob, Hubbard, Roderick E, Surgenor, Alan, Webb, Paul, Wood, Mike, Wright, Lisa and Workman, Paul (2008) NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis. Cancer Research, 68 (8). pp. 2850-2860. ISSN 0008-5472 Mon, 06 Feb 2012 18:30:54 +0000 http://sro.sussex.ac.uk/id/eprint/16867/ http://sro.sussex.ac.uk/id/eprint/16867/ Rappas, Mathieu, Oliver, Antony W and Pearl, Laurence H (2011) Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1. Nucleic Acids Research, 39 (1). pp. 313-324. ISSN 0305-1048 Mon, 06 Feb 2012 18:30:20 +0000 http://sro.sussex.ac.uk/id/eprint/16801/ http://sro.sussex.ac.uk/id/eprint/16801/ Millson, Stefan H, Chua, Chun-Song, Roe, S Mark, Polier, Sigrun, Solovieva, Svetlana, Pearl, Laurence H, Sim, Tiow-Suan, Prodromou, Chrisostomos and Piper, Peter W (2011) Features of the Streptomyces hygroscopicus HtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic Hsp90. FASEB Journal, 25 (11). pp. 3828-3837. ISSN 0892-6638 Mon, 06 Feb 2012 18:22:20 +0000 http://sro.sussex.ac.uk/id/eprint/15984/ http://sro.sussex.ac.uk/id/eprint/15984/ Dore, A S, Kilkenny, M L, Jones, S A, Oliver, A W, Roe, S M, Bell, S D and Pearl, L H (2006) Structure of an archaeal PCNA1-PCNA2-FEN1 complex: elucidating PCNA subunit and client enzyme specificity. Nucleic Acids Research, 34 (16). pp. 4515-4526. Mon, 06 Feb 2012 18:21:02 +0000 http://sro.sussex.ac.uk/id/eprint/15889/ http://sro.sussex.ac.uk/id/eprint/15889/ Hilton, Stephen, Naud, Sebastien, Caldwell, John J, Boxall, Kathy, Burns, Samantha, Anderson, Victoria E, Antoni, Laurent, Allen, Charlotte E, Pearl, Laurence H, Oliver, Antony W, Aherne, G Wynne, Garrett, Michelle D and Collins, Ian (2010) Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2. Bioorganic and Medicinal Chemistry, 18 (2). pp. 707-718. ISSN 0968-0896 Mon, 06 Feb 2012 18:17:27 +0000 http://sro.sussex.ac.uk/id/eprint/15612/ http://sro.sussex.ac.uk/id/eprint/15612/ Kilkenny, Mairi L, Doré, Andrew S, Roe, S Mark, Nestoras, Konstantinos, Ho, Jenny C Y, Watts, Felicity Z and Pearl, Laurence H (2008) Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signalling. Genes & Development, 22 (15). pp. 2034-47. ISSN 0890-9369 Mon, 06 Feb 2012 18:15:06 +0000 http://sro.sussex.ac.uk/id/eprint/15428/ http://sro.sussex.ac.uk/id/eprint/15428/ Doré, Andrew S, Kilkenny, Mairi L, Rzechorzek, Neil J and Pearl, Laurence H (2009) Crystal Structure of the Rad9-Rad1-Hus1 DNA Damage Checkpoint Complex¿Implications for Clamp Loading and Regulation. Molecular Cell, 34 (6). pp. 735-745. ISSN 1097-2765 Mon, 06 Feb 2012 18:12:37 +0000 http://sro.sussex.ac.uk/id/eprint/15227/ http://sro.sussex.ac.uk/id/eprint/15227/ Vaughan, Cara K, Piper, Peter W, Pearl, Laurence H and Prodromou, Chrisostomos (2009) A common conformationally coupled ATPase mechanism for yeast and human cytoplasmic HSP90s. FEBS Journal, 276 (1). pp. 199-209. ISSN 1742-464X http://sro.sussex.ac.uk/id/eprint/2057/ http://sro.sussex.ac.uk/id/eprint/2057/ Kilkenney, M L, Dore, A, Roe, S M, Nestoras, K, Ho, J, Watts, F Z and Pearl, L (2008) Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair. Genes & Development, 22 (15). pp. 2034-2047. ISSN 0890-9369 http://sro.sussex.ac.uk/id/eprint/1021/ http://sro.sussex.ac.uk/id/eprint/1021/ Hinks, J, Roe, Mark, Ho, J C, Watts, Felicity, Phelan, J, McAllister, M and Pearl, Laurence (2003) Expression, purification and preliminary X-ray analysis of the BRCT domain from Rhp9/Crb2. Acta Crystallographica Section D: Biological Crystallography, 59 (Pt 7). 1230-1233.. ISSN 0907-4449