http://sro.sussex.ac.uk/ http://sro.sussex.ac.uk/images/sitelogo.png http://sro.sussex.ac.uk/ Tue, 21 Nov 2023 05:31:42 +0000 Tue, 21 Nov 2023 05:31:42 +0000 en Tue, 25 Aug 2020 06:50:27 +0100 http://sro.sussex.ac.uk/id/eprint/93259/ http://sro.sussex.ac.uk/id/eprint/93259/ Brissett, Nigel C, Zabrady, Katerina, Płociński, Przemysław, Bianchi, Julie, Korycka-Machała, Małgorzata, Brzostek, Anna, Dziadek, Jarosław and Doherty, Aidan J (2020) Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C. Nature Communications, 11. a4196. ISSN 2041-1723 Fri, 22 Sep 2017 11:37:38 +0100 http://sro.sussex.ac.uk/id/eprint/70317/ http://sro.sussex.ac.uk/id/eprint/70317/ Plocinski, Przemyslaw, Brissett, Nigel C, Bianchi, Julie, Brzostek, Anna, Korycka-Machała, Małgorzata, Dziembowski, Andrzej, Dziadek, Jaroslaw and Doherty, Aidan J (2017) DNA Ligase C and Prim-PolC participate in base excision repair in mycobacteria. Nature Communications, 8 (1). a1251 1-12. ISSN 2041-1723 Mon, 22 May 2017 11:59:51 +0100 http://sro.sussex.ac.uk/id/eprint/68177/ http://sro.sussex.ac.uk/id/eprint/68177/ Guilliam, Thomas A, Brissett, Nigel C, Ehlinger, Aaron, Keen, Benjamin A, Kolesar, Peter, Taylor, Elaine, Bailey, Laura J, Lindsay, Howard, Chazin, Walter J and Doherty, Aidan J (2017) Molecular basis for PrimPol recruitment to replication forks by RPA. Nature Communications, 8. a15222. ISSN 2041-1723 Tue, 26 Apr 2016 09:20:24 +0100 http://sro.sussex.ac.uk/id/eprint/60620/ http://sro.sussex.ac.uk/id/eprint/60620/ Hornyak, Peter, Askwith, Trevor, Walker, Sarah, Komulainen, Emilia, Paradowski, Michael, Pennicott, Lewis E, Bartlett, Edward J, Brissett, Nigel C, Raoof, Ali, Watson, Mandy, Jordan, Allan M, Ogilvie, Donald J, Ward, Simon E, Atack, John R, Pearl, Laurence H, Caldecott, Keith W and Oliver, Antony W (2016) Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2. Biochemical Journal, 473 (13). pp. 1869-1879. ISSN 0264-6021 Wed, 20 Apr 2016 10:08:45 +0100 http://sro.sussex.ac.uk/id/eprint/60558/ http://sro.sussex.ac.uk/id/eprint/60558/ Guilliam, Thomas A, Bailey, Laura J, Brissett, Nigel C and Doherty, Aidan J (2016) PolDIP2 interacts with human PrimPol and enhances its DNA polymerase activities. Nucleic Acids Research, 44 (7). pp. 3317-3329. ISSN 0305-1048 Fri, 15 Jan 2016 13:14:53 +0000 http://sro.sussex.ac.uk/id/eprint/59196/ http://sro.sussex.ac.uk/id/eprint/59196/ Guilliam, Thomas A, Keen, Benjamin A, Brissett, Nigel C and Doherty, Aidan J (2015) Primase-polymerases are a functionally diverse superfamily of replication and repair enzymes. Nucleic Acids Research, 43 (14). pp. 6651-6664. ISSN 0305-1048 Fri, 15 Jan 2016 10:26:15 +0000 http://sro.sussex.ac.uk/id/eprint/59197/ http://sro.sussex.ac.uk/id/eprint/59197/ Bartlett, Edward J, Brissett, Nigel C, Plocinski, Przemyslaw, Carlberg, Tom and Doherty, Aidan J (2016) Molecular basis for DNA strand displacement by NHEJ repair polymerases. Nucleic Acids Research, 44 (5). pp. 2173-2186. ISSN 0305-1048 Wed, 02 Jul 2014 07:57:09 +0100 http://sro.sussex.ac.uk/id/eprint/49150/ http://sro.sussex.ac.uk/id/eprint/49150/ Rasheduzzaman, Chowdhury, Brissett, Nigel, Krojer, Tobias, Ho, Chia-hua, Ng, Stanley S, Clifton, Ian J, Ge, Wei, Kershaw, Nadia J, Fox, Gavin C, Muniz, Joao R C, Vollmar, Melanie, Phillips, Claire, Pilka, Ewa S, Kavanagh, Kathryn L, von Delft, Frank, Oppermann, Udo, McDonough, Michael A, Doherty, Aidan and Schofield, Christopher J (2014) Ribosomal oxygenases are structurally conserved from prokaryotes to humans. Nature, 510 (7505). pp. 422-426. ISSN 0028-0836 Thu, 28 Nov 2013 16:21:31 +0000 http://sro.sussex.ac.uk/id/eprint/47178/ http://sro.sussex.ac.uk/id/eprint/47178/ Bartlett, Edward, Brissett, Nigel C and Doherty, Aidan J (2013) Ribonucleolytic resection is required for repair of strand displaced nonhomologous end-joining intermediates. Proceedings of the National Academy of Sciences, 110 (22). E1984-E1991. ISSN 1091-6490 Mon, 23 Apr 2012 11:38:44 +0100 http://sro.sussex.ac.uk/id/eprint/7591/ http://sro.sussex.ac.uk/id/eprint/7591/ Brissett, Nigel C, Martin, Maria J, Pitcher, Robert S, Bianchi, Julie, Juarez, Raquel, Green, Andrew J, Fox, Gavin C, Blanco, Luis and Doherty, Aidan J (2011) Structure of a preternary complex involving a prokaryotic NHEJ DNA polymerase. Molecular Cell, 41 (2). pp. 221-231. ISSN 1097-2765 Mon, 06 Feb 2012 21:28:06 +0000 http://sro.sussex.ac.uk/id/eprint/31343/ http://sro.sussex.ac.uk/id/eprint/31343/ Brissett, Nigel C, Pitcher, Robert S, Juarez, Raquel, Picher, Angel J, Green, Andrew J, Dafforn, Timothy R, Fox, Gavin C, Blanco, Luis and Doherty, Aidan J (2007) Structure of a polymerase-mediated DNA NHEJ synaptic complex. Science, 318. pp. 456-459. ISSN 0028-0836 Mon, 06 Feb 2012 21:23:59 +0000 http://sro.sussex.ac.uk/id/eprint/31078/ http://sro.sussex.ac.uk/id/eprint/31078/ Watts, Felicity Z and Brissett, Nigel C (2010) Linking up and interacting with BRCT domains. DNA Repair, 9 (2). pp. 103-8. ISSN 1568-7864 Mon, 06 Feb 2012 20:43:00 +0000 http://sro.sussex.ac.uk/id/eprint/27648/ http://sro.sussex.ac.uk/id/eprint/27648/ Brissett, Nigel C and Doherty, Aidan J (2009) Repairing DNA double-strand breaks by the prokaryotic non-homologous end-joining pathway. In: Symposium on DNA Damage - From Causes to Cures, Univ Cambridge, Robinson Coll, Cambridge, ENGLAND, DEC 15-17, 2008. Mon, 06 Feb 2012 20:32:06 +0000 http://sro.sussex.ac.uk/id/eprint/26439/ http://sro.sussex.ac.uk/id/eprint/26439/ Pitcher, Robert S, Brissett, Nigel C and Doherty, Aidan J (2007) Nonhomologous end-joining in bacteria: a microbial perspective. Annual Review of Microbiology, 61. pp. 258-282. ISSN 0066-4227 Mon, 06 Feb 2012 19:52:48 +0000 http://sro.sussex.ac.uk/id/eprint/22711/ http://sro.sussex.ac.uk/id/eprint/22711/ Hiner, Alexander N P, Hernández-Ruiz, Josefa, Rodríguez-López, Jose Neptuno, García-Cánovas, Francisco, Brissett, Nigel C, Smith, Andrew T, Arnao, Marino B and Acosta, Manuel (2002) Reactions of the Class II Peroxidases, Lignin Peroxidase and Arthromyces ramosus Peroxidase, with Hydrogen Peroxide. Journal of Biological Chemistry, 277 (30). pp. 26879-26885. ISSN 0021-9258 Mon, 06 Feb 2012 19:26:00 +0000 http://sro.sussex.ac.uk/id/eprint/20543/ http://sro.sussex.ac.uk/id/eprint/20543/ Howes, Barry D, Brissett, Nigel C, Doyle, Wendy A, Smith, Andrew T and Smulevich, Giulietta (2005) Spectroscopic and kinetic properties of the horseradish peroxidase mutant T171S. FEBS Journal, 272 (21). pp. 5514-5521. ISSN 1742-464X Mon, 06 Feb 2012 18:13:42 +0000 http://sro.sussex.ac.uk/id/eprint/15314/ http://sro.sussex.ac.uk/id/eprint/15314/ Chavali, Gayatri B, Ekblad, Caroline M S, Basu, Balaka P, Brissett, Nigel C, Veprintsev, Dmitry, Hughes-Davies, Luke, Kouzarides, Tony, Itzhaki, Laura S and Doherty, Aidan J (2005) Crystal structure of the ENT domain of human EMSY. Journal of Molecular Biology, 350 (5). pp. 964-973. ISSN 0022-2836 http://sro.sussex.ac.uk/id/eprint/744/ http://sro.sussex.ac.uk/id/eprint/744/ Pitcher, R S, Brissett, N, Picher, A J, Andrade, P, Juarez, R, Thompson, D, Fox, G C, Blanco, L and Doherty, A J (2007) Structure and Function of a Mycobacterial NHEJ DNA Repair Polymerase. Journal of Molecular Biology, 366 (2). pp. 391-405. ISSN 0022-2836