The role of SMC proteins in the responses to DNA damage

Lehmann, Alan R. (2005) The role of SMC proteins in the responses to DNA damage. DNA Repair, 4 (3). pp. 309-314. ISSN 1568-7864

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The SMC proteins form the cores of three protein complexes in eukaryotes, cohesin, condensin and the Smc5-6 complex. Cohesin holds sister chromatids together after DNA replication and is involved in both the repair of double-strand breaks by homologous recombination and the intra-S-phase checkpoint. Condensin assists in the condensation of chromosomes at mitosis and also has a role in checkpoint control pathways. The Smc5-6 complex is involved in a variety of DNA repair and damage response pathways by as yet unknown mechanisms, but is also associated with repair by homologous recombination.

Item Type: Article
Additional Information: 1568-7864 Journal Article GDSC121
Depositing User: Gee Wheatley
Date Deposited: 19 Mar 2007
Last Modified: 30 Nov 2012 16:51
Google Scholar:56 Citations
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