Survivin: a protein with dual roles in mitosis and apoptosis

Wheatley, S. P. and McNeish, I. A. (2005) Survivin: a protein with dual roles in mitosis and apoptosis. International Review of Cytology, 247. pp. 35-88. ISSN 0074-7696

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Abstract

Survivin is a fascinating little protein that acts as a component of the chromosomal passenger complex, which is essential for cell division, and as an inhibitor of apoptosis. With dual roles in promoting cell proliferation and preventing apoptosis, it is considered a protein that interfaces life and death. Interest in survivin has been fueled by its abundance in human cancers, where it has potential as a prognostic marker for cancer, and as a target for chemotherapy. Accordingly, since its discovery in 1997, publications on survivin have risen exponentially in basic and clinical fields alike. This review highlights the key advances in our understanding of the cellular function of this protein.

Item Type: Article
Additional Information: GDSC156
Keywords: Amino Acid Sequence Animals Apoptosis/*physiology Apoptosis Regulatory Proteins/physiology Base Sequence Cysteine Proteinase Inhibitors/physiology Humans Intracellular Signaling Peptides and Proteins/physiology Microtubule-Associated Proteins/chemistry/genetics/*physiology Mitosis/*physiology Molecular Sequence Data Neoplasm Proteins/chemistry/genetics/*physiology Neoplasms/metabolism/therapy Protein Isoforms Research Support, Non-U.S. Gov't Xenopus Proteins/physiology
Depositing User: Gee Wheatley
Date Deposited: 19 Mar 2007
Last Modified: 30 Nov 2012 16:51
URI: http://sro.sussex.ac.uk/id/eprint/922
Google Scholar:85 Citations
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