The role of double-strand break repair - insights from human genetics

O'Driscoll, M. and Jeggo, P. A. (2006) The role of double-strand break repair - insights from human genetics. Nature Reviews Genetics, 7 (1). pp. 45-54. ISSN 1471-0056

Full text not available from this repository.

Abstract

The efficient repair of DNA double-strand breaks is crucial in safeguarding the genomic integrity of organisms. Responses to double-strand breaks include complex signal-transduction, cell-cycle-checkpoint and repair pathways. Defects in these pathways lead to several human disorders with pleiotropic clinical features. Dissection of the molecular basis that underlies the diverse clinical features is enhancing our understanding of the damage-response mechanisms and their role in development, and might ultimately facilitate treatment.

Item Type: Article
Additional Information: GDSC152
Depositing User: Gee Wheatley
Date Deposited: 16 Mar 2007
Last Modified: 30 Nov 2012 16:50
URI: http://sro.sussex.ac.uk/id/eprint/902
Google Scholar:259 Citations
📧 Request an update