Guidelines for using quantitative measures of brain magnetic resonance imaging abnormalities in monitoring the treatment of multiple sclerosis

Filippi, M., Horsfield, M. A., Ader, H. J., Barkhof, F., Bruzzi, P., Evans, A., Frank, J. A., Grossman, R. I., McFarland, H. F., Molyneux, P., Paty, D. W., Simon, J., Tofts, P. S., Wolinsky, J. S. and Miller, D. H. (1998) Guidelines for using quantitative measures of brain magnetic resonance imaging abnormalities in monitoring the treatment of multiple sclerosis. Annals of Neurology, 43 (4). pp. 499-506. ISSN 0364-5134

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Abstract

The change of brain lesion load, measured on T2-weighted magnetic resonance imaging (MRI) using computer-assisted techniques, is a widely used secondary endpoint for phase III clinical trials in multiple sclerosis (MS). Collection, transfer, and analysis of the electronic data across multiple centers have all proved challenging and give rise to potential errors. However, many new acquisition schemes and postprocessing techniques have been developed; these may reduce scan times and result in better lesion conspicuity or lessen the human interaction needed for data analysis. This review considers many aspects of the use of MRI in clinical trials for MS and provides international consensus guidelines, derived from a task force of the European Magnetic Resonance Networks in Multiple Sclerosis (MAGNIMS) together with a group of North American experts. The main points considered are the organization of correctly powered trials and selection of participating sites; the appropriate choice of pulse sequences and image acquisition protocol given the current state of technology; quality assurance for data acquisition and analysis; accuracy and reproducibility of lesion load assessments; and the potential for the application of quantitative methods to other MRI-derived measures of disease burden.

Item Type: Article
Keywords: Brain/ pathology Clinical Trials, Phase III Humans Magnetic Resonance Imaging/methods/ standards Monitoring, Physiologic/methods/standards Multiple Sclerosis/ pathology/ therapy Practice Guidelines Reproducibility of Results
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Depositing User: Paul Stephen Tofts
Date Deposited: 14 Mar 2007
Last Modified: 08 Jun 2012 08:25
URI: http://sro.sussex.ac.uk/id/eprint/870
Google Scholar:145 Citations
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