Correlation of magnetic resonance imaging parameters with clinical disability in multiple sclerosis: a preliminary study

Grimaud, J., Barker, G. J., Wang, L., Lai, M., MacManus, D. G., Webb, S. L., Thompson, A. J., McDonald, W. I., Tofts, P. S. and Miller, D. H. (1999) Correlation of magnetic resonance imaging parameters with clinical disability in multiple sclerosis: a preliminary study. Journal of Neurology, 246 (10). pp. 961-7. ISSN 0340-5354

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Abstract

Magnetic resonance imaging (MRI) is frequently used to monitor new treatments in multiple sclerosis (MS), but its role is limited by the uncertain relationship between MRI parameters and clinical disability. A brain MRI study using nine MRI parameters was undertaken in 15 MS patients with a wide spectrum of disability to evaluate the relationship between each parameter and disability. A strong correlation was found between disability (measured using Kurtzke's EDSS) and total lesion load on both proton density (PD; r = 0.79) and T1 (r = 0.71) weighted sequences. There was also a strong correlation of disability with average lesion magnetisation transfer ratio (MTR; r = -0.74) and calculated T1 (r = 0.71) but not with calculated T2 or the average signal intensity of lesions on the conventional T1-weighted, PD-weighted and heavily T2-weighted images. Thus, four parameters which measured either the extent of lesions (PD lesion load) or their pathological severity (MTR, calculated T1, hypointense T1-lesion load) were correlated significantly with disability. While this suggests that such parameters will be useful in treatment trial monitoring, further multi-parameter MRI studies, of larger cohorts and using a wider range of techniques, are indicated.

Item Type: Article
Keywords: Adult Brain/pathology Disability Evaluation Disabled Persons Humans Magnetic Resonance Imaging Middle Aged Multiple Sclerosis/ diagnosis/ physiopathology
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Depositing User: Paul Stephen Tofts
Date Deposited: 14 Mar 2007
Last Modified: 30 Nov 2012 16:50
URI: http://sro.sussex.ac.uk/id/eprint/862
Google Scholar:27 Citations
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