Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols

Tofts, Paul S., Brix, Gunnar, Buckley, David L., Evelhoch, Jeffrey L., Henderson, Elizabeth, Knopp, Michael V., Larsson, Henrik B., Lee, Ting-Yim, Mayr, Nina A., Parker, Geoffrey J., Port, Ruediger E., Taylor, June and Weisskoff, Robert M. (1999) Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols. Journal of Magnetic Resonance Imaging, 10 (3). pp. 223-32. ISSN 1053-1807

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Abstract

We describe a standard set of quantity names and symbols related to the estimation of kinetic parameters from dynamic contrast-enhanced T(1)-weighted magnetic resonance imaging data, using diffusable agents such as gadopentetate dimeglumine (Gd-DTPA). These include a) the volume transfer constant K(trans) (min(-1)); b) the volume of extravascular extracellular space (EES) per unit volume of tissue v(e) (0 < v(e) < 1); and c) the flux rate constant between EES and plasma k(ep) (min(-1)). The rate constant is the ratio of the transfer constant to the EES (k(ep) = K(trans)/v(e)). Under flow-limited conditions K(trans) equals the blood plasma flow per unit volume of tissue; under permeability-limited conditions K(trans) equals the permeability surface area product per unit volume of tissue. We relate these quantities to previously published work from our groups; our future publications will refer to these standardized terms, and we propose that these be adopted as international standards.

Item Type: Article
Keywords: Contrast Media/ pharmacokinetics Diffusion Extracellular Space/metabolism Gadolinium DTPA/diagnostic use/ pharmacokinetics Humans Image Enhancement/methods Magnetic Resonance Imaging/ methods Models, Biological Terminology
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Depositing User: Paul Stephen Tofts
Date Deposited: 28 Feb 2007
Last Modified: 30 Nov 2012 16:50
URI: http://sro.sussex.ac.uk/id/eprint/823
Google Scholar:1105 Citations
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