Magnetisation transfer ratio histogram analysis of primary progressive and other multiple sclerosis subgroups

Dehmeshki, J., Silver, N. C., Leary, S. M., Tofts, P. S., Thompson, A. J. and Miller, D. H. (2001) Magnetisation transfer ratio histogram analysis of primary progressive and other multiple sclerosis subgroups. Journal of the Neurological Sciences, 185 (1). pp. 11-7. ISSN 0022-510X

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Abstract

INTRODUCTION: Global magnetisation transfer ration (MTR) histogram analysis in the brain offers a method for evaluating pathological change both as a result of lesions and microscopic changes in normal appearing tissues. METHODS: 39 controls and 83 MS patients (46 primary progressive, 11 benign, 10 relapsing-remitting, 16 secondary progressive) were studied to explore the relationship of six conventional MTR histogram parameters with MS clinical subgroups and disability. Principal component (PC) analysis, which makes use of all the histogram data, was also used to examine the relationship between the MTR histogram and disability. RESULTS: When primary progressive patients were compared to controls, there were abnormalities of average MTR, and MTR at the 25th, 50th and 75th percentile. Disabled relapsing onset patients exhibited abnormalities in the same four parameters. Benign and nondisabled relapsing onset patients exhibited no significant abnormalities. Modest correlations were observed between disability and individual MTR parameters in relapse onset but not primary progressive patients--PC analysis revealed stronger and significant associations with disability in both subgroups. (r=0.40 for primary progressive and r=0.51 for relapsing onset). CONCLUSION: A number of MTR parameters are abnormal in primary progressive MS. MTR abnormalities are seen in disabled patients, whether of relapsing or primary progressive onset. The improved correlation with disability obtained by PC analysis suggests a useful role of this method for following clinically relevant pathological changes depicted in the MTR histogram.

Item Type: Article
Keywords: Adult Cohort Studies Diagnosis, Differential Disability Evaluation Female Humans Magnetic Resonance Imaging Male Middle Aged Multiple Sclerosis, Chronic Progressive/ diagnosis Multiple Sclerosis, Relapsing-Remitting/ diagnosis
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Depositing User: Paul Stephen Tofts
Date Deposited: 28 Feb 2007
Last Modified: 30 Nov 2012 16:50
URI: http://sro.sussex.ac.uk/id/eprint/819
Google Scholar:27 Citations
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