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Pathophysiological and cognitive mechanisms of fatigue in multiple sclerosis

journal contribution
posted on 2023-06-09, 16:42 authored by Zina-Mary Manjaly, Neil Harrison, Hugo CritchleyHugo Critchley, Cao Tri Do, Gabor Stefanics, Nicole Wenderoth, Andreas Lutterotti, Alfred Müller, Klaas Enno Stephan
Fatigue is one of the most common symptoms in multiple sclerosis (MS), with a major impact on patients’ quality of life. Currently, treatment proceeds by trial and error with limited success, probably due to the presence of multiple different underlying mechanisms. Recent neuroscientific advances offer the potential to develop tools for differentiating these mechanisms in individual patients and ultimately provide a principled basis for treatment selection. However, development of these tools for differential diagnosis will require guidance by pathophysiological and cognitive theories that propose mechanisms which can be assessed in individual patients. This article provides an overview of contemporary pathophysiological theories of fatigue in MS and discusses how the mechanisms they propose may become measurable with emerging technologies and thus lay a foundation for future personalised treatments.

History

Publication status

  • Published

File Version

  • Published version

Journal

Journal of Neurology, Neurosurgery and Psychiatry

ISSN

0022-3050

Publisher

BMJ Publishing Group

Issue

6

Volume

90

Page range

642-651

Department affiliated with

  • BSMS Neuroscience Publications

Research groups affiliated with

  • Sackler Centre for Consciousness Science Publications
  • Sussex Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2019-01-31

First Open Access (FOA) Date

2019-01-31

First Compliant Deposit (FCD) Date

2019-01-30

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