Baxter_et_al-2019-BioEssays.pdf (1018.83 kB)
Are SMC complexes loop extruding factors? Linking theory with fact
Version 2 2023-06-12, 08:58
Version 1 2023-06-09, 16:36
journal contribution
posted on 2023-06-12, 08:58 authored by Jon BaxterJon Baxter, Antony OliverAntony Oliver, Stephanie A SchalbetterThe extreme length of chromosomal DNA requires organizing mechanisms to both promote functional genetic interactions and ensure faithful chromosome segregation when cells divide. Microscopy and genome-wide contact frequency analyses indicate that intra-chromosomal looping of DNA is a primary pathway of chromosomal organization during all stages of the cell cycle. DNA loop extrusion has emerged as a unifying model for how chromosome loops are formed in cis in different genomic contexts and cell cycle stages. The highly conserved family of SMC complexes have been found to be required for DNA cis-looping and have been suggested to be the enzymatic core of loop extruding machines. Here, the current body of evidence available for the in vivo and in vitro action of SMC complexes is discussed and compared to the predictions made by the loop extrusion model. How SMC complexes may differentially act on chromatin to generate DNA loops and how they could work to generate the dynamic and functionally appropriate organization of DNA in cells is explored.
Funding
Investigating the interplay between SMC complexes and Topoisomerase II; G2520; BBSRC; BB/S001425/1
How do Smc5/6 interactions with DNA coordinate replication and recombination?; G2119; MRC-MEDICAL RESEARCH COUNCIL; MR/P018955/1
History
Publication status
- Published
File Version
- Published version
Journal
BioEssaysISSN
1521-1878Publisher
WileyExternal DOI
Issue
1Volume
41Page range
1800182 1-10Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
Research groups affiliated with
- Genome Damage and Stability Centre Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2019-01-22First Open Access (FOA) Date
2019-01-22First Compliant Deposit (FCD) Date
2019-01-21Usage metrics
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