Preliminary magnetic resonance study of the macromolecular proton fraction in white matter: a potential marker of myelin?

Davies, G. R., Ramani, A., Dalton, C. M., Tozer, D. J., Wheeler-Kingshott, C. A., Barker, G. J., Thompson, A. J., Miller, D. H. and Tofts, P. S. (2003) Preliminary magnetic resonance study of the macromolecular proton fraction in white matter: a potential marker of myelin? Multiple Sclerosis, 9 (3). pp. 246-9. ISSN 1352-4585

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Abstract

We report on a new quantitative magnetization transfer (MT) technique that allows for the in vivo estimation of the macromolecular proton fraction (f) and the bound pool T2 relaxation time (T2b), whilst permitting whole brain coverage. In this pilot study, five subjects with multiple sclerosis (MS) and five healthy controls were studied. Both f and T2b were significantly different between MS lesions and normal control white matter (WM). Relationships between f and T1 relaxation time [Spearmans rank correlation coefficient (r(s)) = -0.97, P < 0.001] and f and the magnetization transfer ratio (MTR; r(s) = 0.80, P < 0.001) were observed. Compared with MTR, f and T2b have the potential advantage of relative independence from MT acquisition protocol while offering more pathologically specific information. In particular, f may provide a more direct indication of myelin content in WM.

Item Type: Article
Keywords: Adult Biological Markers/analysis Brain/ metabolism/pathology Case-Control Studies Female Humans Macromolecular Substances Magnetic Resonance Imaging Male Middle Aged Multiple Sclerosis/diagnosis/ metabolism Myelin Sheath/metabolism Periaqueductal Gray/metabolism Pilot Projects Protons Tissue Distribution
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Depositing User: Paul Stephen Tofts
Date Deposited: 28 Feb 2007
Last Modified: 30 Nov 2012 16:50
URI: http://sro.sussex.ac.uk/id/eprint/814
Google Scholar:19 Citations
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