University of Sussex
Browse
Genetic correlation between multiple myeloma and chronic lymphocytic leukaemia provides evidence for shared aetiology.pdf (749.23 kB)

Genetic correlation between multiple myeloma and chronic lymphocytic leukaemia provides evidence for shared aetiology

Download (749.23 kB)
journal contribution
posted on 2023-06-09, 16:33 authored by Molly Went, Amit Sud, Helen Speedy, Nicola J Sunter, Asta Försti, Philip J Law, David C Johnson, Fabio Mirabella, Amy Holroyd, Ni Li, Giulia Orlando, Niels Weinhold, Mark van Duin, Bowang Chen, Jonathan S Mitchell, Larry Mansouri, Gunnar Juliusson, Karin E Smedby, Sandrine Jayne, Aneela Majid, Claire Dearden, David J Allsup, James R Bailey, Guy Pratt, Christopher PepperChristopher Pepper, Chris Fegan, Richard Rosenquist, Rowan Kuiper, Owen W Stephens, Uta Bertsch, Peter Broderick, Hermann Einsele, Walter M Gregory, Jens Hillengass, Per Hoffmann, Graham H Jackson, Karl-Heinz Jöckel, Jolanta Nickel, Markus M. Nöthen, Miguel Inacio da Silva Filho, Hauke Thomsen, Brian A Walker, Annemiek Broyl, Faith E Davies, Markus Hansson, Hartmut Goldschmidt, Martin J S Dyer, Martin Kaiser, Pieter Sonneveld, Gareth J Morgan, Kari Hemminki, Björn Nilsson, Daniel Catovsky, James M Allan, Richard S Houlston
The clustering of different types of B-cell malignancies in families raises the possibility of shared aetiology. To examine this, we performed cross-trait linkage disequilibrium (LD)-score regression of multiple myeloma (MM) and chronic lymphocytic leukaemia (CLL) genome-wide association study (GWAS) data sets, totalling 11,734 cases and 29,468 controls. A significant genetic correlation between these two B-cell malignancies was shown (Rg = 0.4, P = 0.0046). Furthermore, four of the 45 known CLL risk loci were shown to associate with MM risk and five of the 23 known MM risk loci associate with CLL risk. By integrating eQTL, Hi-C and ChIP-seq data, we show that these pleiotropic risk loci are enriched for B-cell regulatory elements and implicate B-cell developmental genes. These data identify shared biological pathways influencing the development of CLL and, MM and further our understanding of the aetiological basis of these B-cell malignancies.

History

Publication status

  • Published

File Version

  • Published version

Journal

Blood Cancer Journal

ISSN

2044-5385

Publisher

Springer Nature

Issue

1

Volume

9

Page range

1-9

Department affiliated with

  • BSMS Publications

Research groups affiliated with

  • Haematology Research Group Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2019-01-17

First Open Access (FOA) Date

2019-01-17

First Compliant Deposit (FCD) Date

2019-01-17

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC