voroconazole_acceptted version.pdf (687.3 kB)
Improved delivery of voriconazole to Aspergillus fumigatus through solid lipid nanoparticles as an effective carrier
journal contribution
posted on 2023-06-09, 15:04 authored by Hamid Reza Kelidari, Roghayeh Babaei, Mojtaba Nabili, Tahereh Shokohi, Majid Saeedi, Sara Gholami, Maryam Moazeni, Ali NokhodchiNovel voriconazole-loaded solid lipid nanoparticles (VRC-SLNs) were prepared via probe-ultrasonication method, and the resultant nanoparticles were tested on A. fumigatus. Voriconazole-loaded solid lipid nanoparticles were prepared using the probe ultrasonication technique. Photon correlation spectroscopy (PCS) was used to determine the average particle size and zeta potential of SLN formulations. Transmission electron microscopy was also used to determine the morphology of solid lipid nanoparticles. To determine MIC for all SLN formulations against strains of Aspergillus the Clinical and Laboratory Standards Institute guidelines was followed. The results showed that SLNs containing voriconazole exhibited almost spherical shape with a diameter and zeta potential of 286.6?±?4.7?nm and -15?±?4.1?mV respectively. This novel formulation of VRC led to a significant reduction in MICs for all Aspergillus either VRC-susceptible or VRC-resistant isolates (P < 0.05). The MIC50 drug concentration was obtained as 0.015?µg/ml for both VRC-susceptible strains of A. fumigates while it was 0.25?µg/ml against VRC (p?
History
Publication status
- Published
File Version
- Accepted version
Journal
Colloids and Surfaces A: Physicochemical and Engineering AspectsISSN
0927-7757Publisher
ElsevierExternal DOI
Volume
558Page range
338-342Department affiliated with
- Chemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2018-09-13First Open Access (FOA) Date
2019-08-31First Compliant Deposit (FCD) Date
2018-09-13Usage metrics
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