Intracellular microbe whole-genome expression profiling: methodological considerations and biological inferences

Waddell, Simon J and Butcher, Philip D (2009) Intracellular microbe whole-genome expression profiling: methodological considerations and biological inferences. In: Ulrich, E Schaible and Haas, Albert (eds.) Intracellular Niches of Pathogens – A Microbe’s Guide through the Host Cell. Wiley-VCH Publishers. ISBN 9783527322077

[img] PDF - Accepted Version
Restricted to SRO admin only

Download (179kB)

Abstract

Understanding the mechanisms by which microbes survive in their host intracellular environments is an essential precursor to developing novel intervention strategies that might exploit the interplay between host and microbe. Transcriptional profiling allows us a glimpse of these molecular interactions and promises to reveal much of this dialogue in both pathogenic and symbiotic settings. Such studies will underpin the development of antivirulence strategies for new therapeutics. This chapter aims
to describe the challenges of studying microbial RNA expression from intracellular and in vivo scenarios, and to detail a fraction of the insights acquired from this rapidly
expanding field, driven by the recent availability of microbe whole-genome sequence information.

Item Type: Book Section
Schools and Departments: Brighton and Sussex Medical School > Global Health and Infection
Subjects: Q Science > Q Science (General)
Q Science > QR Microbiology > QR0075 Bacteria
Q Science > QR Microbiology > QR0171 Microorganisms in the animal body
Q Science > QR Microbiology > QR0180 Immunology
Related URLs:
Depositing User: Simon Waddell
Date Deposited: 08 May 2012 10:36
Last Modified: 22 Sep 2017 11:26
URI: http://sro.sussex.ac.uk/id/eprint/7651

View download statistics for this item

📧 Request an update