Waddell_Reprogramming transcriptome DDT_DM_Author version_2010.pdf (215.72 kB)
Reprogramming the Mycobacterium tuberculosis transcriptome during pathogenesis
Transcriptional profiling has revealed that Mycobacterium tuberculosis adapts both its metabolic and respiratory states during infection, utilising lipids as a carbon source and switching to alternative electron acceptors. These global gene expression datasets may be exploited to identify virulence determinants and to screen for new targets for rational drug design. Characterising the changing physiological predicament of distinct M. tb populations during infection will help expose the fundamental biology of M. tb highlighting mechanisms that influence tuberculosis pathogenicity.
History
Publication status
- Published
File Version
- Accepted version
Journal
Drug Discovery Today: Disease MechanismsISSN
17406765Publisher
Elsevier LtdExternal DOI
Issue
1Volume
7Article number
e67-e73Department affiliated with
- Global Health and Infection Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2012-05-09First Open Access (FOA) Date
2017-01-23First Compliant Deposit (FCD) Date
2017-01-23Usage metrics
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