Myocardial depressant effects of interleukin 6 in meningococcal sepsis are regulated by p38 mitogen-activated protein kinase

Pathan, Nazima, Franklin, Joanne L, Eleftherohorinou, Hariklia, Wright, Victoria J, Hemingway, Cheryl A, Waddell, Simon J, Griffiths, Michael, Dennis, Jayne L, Relman, David A, Harding, Sian E and Levin, Michael (2011) Myocardial depressant effects of interleukin 6 in meningococcal sepsis are regulated by p38 mitogen-activated protein kinase. Critical Care Medicine, 39 (7). pp. 1692-1711. ISSN 0090-3493

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Abstract

Our findings demonstrate an integral role of the p38 mitogen-activated protein kinase pathway in interleukin 6-mediated cardiac contractile dysfunction and inotrope insensitivity. Dysregulation of the p38 mitogen-activated protein kinase pathway in meningococcal septicemia suggests that this pathway may be an important target for novel therapies to reverse myocardial dysfunction in patients with meningococcal septic shock who are not responsive to inotropic support.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical and Laboratory Investigation
Subjects: Q Science > Q Science (General)
Q Science > QR Microbiology > QR0180 Immunology
R Medicine > RJ Pediatrics
Depositing User: Simon Waddell
Date Deposited: 17 Jul 2012 13:42
Last Modified: 06 Mar 2017 15:15
URI: http://sro.sussex.ac.uk/id/eprint/7642

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