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Myocardial depressant effects of interleukin 6 in meningococcal sepsis are regulated by p38 mitogen-activated protein kinase

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posted on 2023-06-07, 16:23 authored by Nazima Pathan, Joanne L Franklin, Hariklia Eleftherohorinou, Victoria J Wright, Cheryl A Hemingway, Simon WaddellSimon Waddell, Michael Griffiths, Jayne L Dennis, David A Relman, Sian E Harding, Michael Levin
Our findings demonstrate an integral role of the p38 mitogen-activated protein kinase pathway in interleukin 6-mediated cardiac contractile dysfunction and inotrope insensitivity. Dysregulation of the p38 mitogen-activated protein kinase pathway in meningococcal septicemia suggests that this pathway may be an important target for novel therapies to reverse myocardial dysfunction in patients with meningococcal septic shock who are not responsive to inotropic support.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Critical Care Medicine

ISSN

0090-3493

Publisher

Lippincott, Williams & Wilkins

Issue

7

Volume

39

Page range

1692-1711

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2012-07-17

First Open Access (FOA) Date

2017-01-23

First Compliant Deposit (FCD) Date

2017-01-23

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