CCM revised manuscriptfinaldraft_plus_figs.pdf (785.11 kB)
Myocardial depressant effects of interleukin 6 in meningococcal sepsis are regulated by p38 mitogen-activated protein kinase
journal contribution
posted on 2023-06-07, 16:23 authored by Nazima Pathan, Joanne L Franklin, Hariklia Eleftherohorinou, Victoria J Wright, Cheryl A Hemingway, Simon WaddellSimon Waddell, Michael Griffiths, Jayne L Dennis, David A Relman, Sian E Harding, Michael LevinOur findings demonstrate an integral role of the p38 mitogen-activated protein kinase pathway in interleukin 6-mediated cardiac contractile dysfunction and inotrope insensitivity. Dysregulation of the p38 mitogen-activated protein kinase pathway in meningococcal septicemia suggests that this pathway may be an important target for novel therapies to reverse myocardial dysfunction in patients with meningococcal septic shock who are not responsive to inotropic support.
History
Publication status
- Published
File Version
- Accepted version
Journal
Critical Care MedicineISSN
0090-3493Publisher
Lippincott, Williams & WilkinsExternal DOI
Issue
7Volume
39Page range
1692-1711Department affiliated with
- Clinical and Experimental Medicine Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2012-07-17First Open Access (FOA) Date
2017-01-23First Compliant Deposit (FCD) Date
2017-01-23Usage metrics
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