Contrasting transcriptional responses of a virulent and an attenuated strain of Mycobacterium tuberculosis infecting macrophages

Li, Alice H, Waddell, Simon J, Hinds, Jason, Malloff, Chad A, Bains, Manjeet, Hancock, Robert E, Lam, Wan L, Butcher, Philip D and Stokes, Richard W (2010) Contrasting transcriptional responses of a virulent and an attenuated strain of Mycobacterium tuberculosis infecting macrophages. PLoS ONE, 5 (6). e11066. ISSN 1932-6203

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Abstract

Along with the recent identification of single nucleotide polymorphisms in H37Ra when compared to H37Rv, our demonstration of differential expression of PhoP-regulated and ESX-1 region-related genes during macrophage infection further highlights the significance of these genes in the attenuation of H37Ra.

Item Type: Article
Subjects: Q Science > Q Science (General)
Q Science > QR Microbiology > QR0075 Bacteria
Q Science > QR Microbiology > QR0171 Microorganisms in the animal body
Depositing User: Simon Waddell
Date Deposited: 17 Jul 2012 14:15
Last Modified: 07 Mar 2017 07:03
URI: http://sro.sussex.ac.uk/id/eprint/7639

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