Regional brain atrophy and functional disconnection across Alzheimer's disease evolution

Gili, T, Cercignani, M, Serra, L, Perri, R, Giove, F, Maraviglia, B, Caltagirone, C and Bozzali, M (2011) Regional brain atrophy and functional disconnection across Alzheimer's disease evolution. Journal of Neurology, Neurosurgery and Psychiatry, 82 (1). pp. 58-66. ISSN 0022-3050

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Abstract

This study indicates that disconnection precedes GM atrophy in the PCC, which is a critical area of the DMN, and supports the hypothesis that GM atrophy in specific regions of AD brains likely reflects a long term effect of brain disconnection. In this context, our study indicates that GM atrophy in PCC accompanies the conversion from MCI to AD.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical and Laboratory Investigation
Subjects: R Medicine > R Medicine (General) > R895 Medical physics. Medical radiology. Nuclear medicine
R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders
Depositing User: Mara Cercignani
Date Deposited: 24 Apr 2012 12:06
Last Modified: 30 Nov 2012 16:56
URI: http://sro.sussex.ac.uk/id/eprint/7534
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