Mathematical model of immune response to hepatitis B

Fatehi Chenar, F, Kyrychko, Y N and Blyuss, K B (2018) Mathematical model of immune response to hepatitis B. Journal of Theoretical Biology, 447. pp. 98-110. ISSN 0022-5193

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Abstract

A new detailed mathematical model for dynamics of immune response to hepatitis B is proposed, which takes into account contributions from innate and adaptive immune responses, as well as cytokines. Stability analysis of different steady states is performed to identify parameter regions where the model exhibits clearance of infection, maintenance of a chronic infection, or periodic oscillations. Effects of nucleoside analogues and interferon treatments are analysed, and the critical drug efficiency is determined.

Item Type: Article
Schools and Departments: School of Mathematical and Physical Sciences > Mathematics
Research Centres and Groups: Mathematics Applied to Biology Research Group
Subjects: Q Science > QA Mathematics
Q Science > QR Microbiology > QR0180 Immunology
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Depositing User: Konstantin Blyuss
Date Deposited: 11 Apr 2018 14:52
Last Modified: 11 Apr 2018 14:52
URI: http://sro.sussex.ac.uk/id/eprint/75024

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