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Mathematical model of immune response to hepatitis B
journal contribution
posted on 2023-06-09, 12:50 authored by F Fatehi Chenar, Yuliya KyrychkoYuliya Kyrychko, Konstantin BlyussKonstantin BlyussA new detailed mathematical model for dynamics of immune response to hepatitis B is proposed, which takes into account contributions from innate and adaptive immune responses, as well as cytokines. Stability analysis of different steady states is performed to identify parameter regions where the model exhibits clearance of infection, maintenance of a chronic infection, or periodic oscillations. Effects of nucleoside analogues and interferon treatments are analysed, and the critical drug efficiency is determined.
History
Publication status
- Published
File Version
- Accepted version
Journal
Journal of Theoretical BiologyISSN
0022-5193Publisher
ElsevierExternal DOI
Volume
447Page range
98-110Department affiliated with
- Mathematics Publications
Research groups affiliated with
- Mathematics Applied to Biology Research Group Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2018-04-11First Open Access (FOA) Date
2019-03-21First Compliant Deposit (FCD) Date
2018-04-11Usage metrics
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