Seasonal variation in the performance of QuantiFERON-TB Gold In-Tube assays used for the diagnosis of tuberculosis infection

Tebrueggea, Marc, Curtis, Nigel, Clifford, Vanessa, Fernandez-Turienzof, Cristina, Kleinb, Nigel, Fidler, Katy, Mansoura, Salah, Elkingtona, Paul and Morris-Jones, Stephen (2018) Seasonal variation in the performance of QuantiFERON-TB Gold In-Tube assays used for the diagnosis of tuberculosis infection. Tuberculosis, 110. pp. 26-29. ISSN 1472-9792

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Abstract

This study aimed to determine whether there are seasonal changes in the performance of QuantiFERON-TB Gold In-Tube (QFT-GIT) assays, an interferon-gamma release assay widely used for the diagnosis of tuberculosis infection. Results of 31,932 QFT-GIT assays performed at a large independent, accredited diagnostic service provider in London, UK over a 4.5-year-period were analysed. The proportion of positive results was significantly lower in autumn (14.8%) than in spring (16.0%; p=0.0366) and summer (17.5%; p < 0.0001), but similar to winter (15.2%; p=0.4711). The proportion of indeterminate results was significantly higher in autumn (8.2%)than in spring (6.2%; p < 0.0001), summer (4.8%; p < 0.0001), and winter (6.2%; p < 0.0001). The highest proportions of indeterminate results were observed in October (8.4%) and November (8.8%), the lowest in June (4.5%). Our data show that significant seasonal variation occurs in the performance of QFT-GIT assays in a
temperate climate setting. Potential underlying mechanisms, including host and environmental factors, are discussed.

Item Type: Article
Keywords: Tuberculosis Interferon-gamma release assay Performance Indeterminate Seasonality
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Subjects: R Medicine > RJ Pediatrics > RJ0101 Child health. Child health services
Depositing User: Judy Keogh
Date Deposited: 04 Apr 2018 15:58
Last Modified: 04 Apr 2018 15:58
URI: http://sro.sussex.ac.uk/id/eprint/74824
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