Neural circuits of eating behaviour: opportunities for therapeutic development

Clifton, Peter G (2017) Neural circuits of eating behaviour: opportunities for therapeutic development. Journal of Psychopharmacology, 31 (11). pp. 1388-1402. ISSN 0269-8811

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Abstract

Understanding of the neural and physiological substrates of hunger and satiety has increased rapidly over the last three decades, and pharmacological targets have already been identified for the treatment of obesity that has moved from pre-clinical screening to therapies approved by regulatory authorities. Initially, this review describes the way in which physiological signals of energy availability interact with hedonic and rewarding properties of food to modulate the neural circuitry that supports eating behaviour. This is followed by a brief account of current and promising targets for drug development and a review of the wide range of preclinical paradigms that model important influences on human eating behaviour, and can be used to guide early stages of the drug development process.

Item Type: Article
Keywords: Obesity, eating disorders, drug development, satiety
Schools and Departments: School of Psychology > Psychology
Subjects: B Philosophy. Psychology. Religion
Depositing User: Lene Hyltoft
Date Deposited: 05 Apr 2018 09:55
Last Modified: 05 Apr 2018 09:55
URI: http://sro.sussex.ac.uk/id/eprint/74676

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