Integrating DNA damage repair with the cell cycle

Murray, Johanne M and Carr, Antony M (2018) Integrating DNA damage repair with the cell cycle. Current Opinion in Cell Biology, 52. pp. 120-125. ISSN 0955-0674

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Abstract

Abstract
DNA is labile and constantly subject to damage. In addition to external mutagens, DNA is continuously damaged by the aqueous environment, cellular metabolites and is prone to strand breakage during replication. Cell duplication is orchestrated by the cell division cycle and specific DNA structures are processed differently depending on where in the cell cycle they are detected. This is often because a specific structure is physiological in one context, for example during DNA replication, while indicating a potentially pathological event in another, such as interphase or mitosis. Thus, contextualising the biochemical entity with respect to cell cycle progression
provides information necessary to appropriately regulate DNA processing activities.
We review the links between DNA repair and cell cycle context, drawing together
recent advances.

Item Type: Article
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
Research Centres and Groups: Genome Damage and Stability Centre
Depositing User: Paula Amiet-West
Date Deposited: 23 Mar 2018 14:49
Last Modified: 23 May 2018 11:27
URI: http://sro.sussex.ac.uk/id/eprint/74618

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Project NameSussex Project NumberFunderFunder Ref
Replication arrest, restart and genome instabilityG1829WELLCOME TRUST110047/Z/15/Z
How do Smc5/6 interactions with DNA coordinate replication and recombination?G2119MRC-MEDICAL RESEARCH COUNCILMR/P018955/1