The verbal nature of worry in generalized anxiety: Insights from the brain

Makovac, Elena, Smallwood, Jonathan, Watson, David R, Meeten, Frances, Critchley, Hugo D and Ottaviani, Cristina (2017) The verbal nature of worry in generalized anxiety: Insights from the brain. NeuroImage: Clinical, 17. pp. 882-892. ISSN 22131582

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Abstract

Background: The Cognitive Avoidance Theory of Worry argues that worry is a cognitive strategy adopted to control the physiological arousal associated with anxiety. According to this theory, pathological worry, as in Generalized Anxiety Disorder (GAD), is verbal in nature, negative and abstract, rather than concrete. Neuroimaging studies link the expression of worry to characteristic modes of brain functional connectivity, especially in relation to the amygdala. However, the distinctive features of worry (verbal, abstract, negative), and their relationship to physiological arousal, have not so far been mapped to brain function. Methods: We addressed this omission by undertaking a resting-state functional magnetic resonance neuroimaging study of 19 patients with GAD and 21 controls, before and after induction of perseverative cognitions, while measuring emotional bodily arousal from heart rate (HR). Seed-based analyses quantified brain changes in whole brain functional connectivity from the amygdala.
Results: In GAD, the induction increased negative thoughts and their verbal content. In line with predictions, the verbal expression of worry in GAD was associated with higher HR at baseline and attenuated HR increases after induction of perseverative cognitions. Within brain, the increased use of words during worry, and the associated dampening of HR after induction were mediated by the strength of functional connectivity between the amygdala and default mode network ‘hubs’ and the opercular cortex. The negative content of worry was further related to functional communication between amygdala and cingulo-opercular and temporal cortices. Conclusions: Findings provide a neurobiological basis for the impact of verbal worry on HR in GAD.

Item Type: Article
Keywords: Generalized anxiety disorder, Amygdala, Functional connectivity, Worry, Heart rate, New York Cognition Questionnaire
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
Research Centres and Groups: Sackler Centre for Consciousness Science
Depositing User: Alexei Fisk
Date Deposited: 14 Mar 2018 17:02
Last Modified: 23 Mar 2018 16:00
URI: http://sro.sussex.ac.uk/id/eprint/74422

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Project NameSussex Project NumberFunderFunder Ref
Young Researcher GrantUnsetItalian Ministry of HealthGR2010-2312442
Young Researcher GrantUnsetItalian Ministry of HealthGR2011-02348232