The association between arterial stiffness, initial stroke severity, and 3 week outcomes in ischaemic stroke patients

Ormerod, Emma, Ali, Khalid, Cameron, James, Malik, Muzaffar, Lee, Richard, Getov, Spas and Rajkumar, Chakravarthi (2017) The association between arterial stiffness, initial stroke severity, and 3 week outcomes in ischaemic stroke patients. Journal of Stroke & Cerebrovascular Diseases, 26 (11). pp. 2541-2546. ISSN 1052-3057

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Abstract

Objectives: Vascular compliance is emerging as a useful cardiovascular risk factor. The aim of this study was to investigate the association between arterial stiffness and stroke severity at presentation and at three weeks.

Methods: From an initial sample of 73 patients, 42 were included (55% male, mean age 71 years) with acute ischaemic stroke, over a 15 month period. Stroke subtypes were classified into LACI, PACI and POCI. Arterial stiffness was measured by QKD using 24-hour ambulatory blood pressure and ECG monitoring. The measured QKD values were then corrected for a heart rate of 60bpm and a systolic blood pressure (SBP) of 100 mmHg (QKD100-60). Stroke severity was assessed on admission and after 3 weeks, using the National Institute of Health Stroke Scale (NIHSS).

Results: There was a non-significant weak correlation between initial stroke severity and QKD100-60 (r= -0.3, p = 0.08). This correlation was weaker at 3 weeks (r= ¬0.125, p=0.47). There was no difference in NIHSS at week 0 and 3, or QKD100-60, between the different stroke types (LACI, PACI and POCI) or dipper versus non-dippers and reverse dippers.

Conclusions: This study highlights the need for further research into the association between QKD and initial stroke severity.

Item Type: Article
Keywords: stroke outcome, arterial stiffness, QKD, QKD100-60, NIHSS
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
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Depositing User: Marie Shelton
Date Deposited: 23 Mar 2018 14:41
Last Modified: 03 Jul 2018 01:00
URI: http://sro.sussex.ac.uk/id/eprint/74403

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